Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Hovenia dulcis Thunb. Ethanol Extract on the Melanogenesis in B16F10 Melanoma Cell

지구자(枳椇子)에탄올추출물이 B16F10흑색종세포의 멜라닌생성에 대한 효과

  • Kim, Jun-Ho (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Moon, Dea-Won (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choi, Mi-Eun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lim, Gyu-Sang (Research Center of Traditional Korean Medicine, WonkWang University) ;
  • Mun, Yeun-Ja (Research Center of Traditional Korean Medicine, WonkWang University) ;
  • Woo, Won-Hong (Research Center of Traditional Korean Medicine, WonkWang University)
  • 김준호 (원광대학교 한의학전문대학원 한양지원개발학과) ;
  • 문대원 (원광대학교 한의학전문대학원 한양지원개발학과) ;
  • 최미은 (원광대학교 한의학전문대학원 한양지원개발학과) ;
  • 임규상 (원광대학교 한국전통의학연구소) ;
  • 문연자 (원광대학교 한국전통의학연구소) ;
  • 우원홍 (원광대학교 한국전통의학연구소)
  • Published : 2009.04.25
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Abstract

Acquired pigmentary skin diseases such as abnormal melanogenesis, vitiligo, chloasma and inflammatory pigmentation are related to regulate the melanin production, In this study, an ethanol extract of Hovenia dulcis Thunb.(EHD) makedly inhibited melanin biosynthesis and suppressed, the protein expression of tyrosinase, tyrosinase-related protein 1(TRP-1), and tyrosinase-related protein 2(TRP-2) in B16F10 cells. On the other hand, EHD did not inhibit mushroom tyrosinase activity. These results indicate that EHD may contribute to the inhibition of melanin biosynthesis through regulating tyrosinase activity and expression, and serve as a new candidate in the design of new skin-whitening or therapeutic agents.

Keywords

References

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