Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Inhibitory Effect of Deer Antler on Osteoclastic Bone Resorption

파골세포의 골 흡수에 미치는 녹용의 억제효과

  • Kim, Yun-Kyung (Department of Oriental Pharmacy, School of Pharmacy, School of Medicine, Wonkwang University) ;
  • Choi, Yun-Hong (Department of Anatomy, School of Medicine, Wonkwang University) ;
  • Song, Jeong-Hoon (Department of Plastic Surgery, School of Medicine, Wonkwang University) ;
  • Jang, Sung-Jo (Department of Neurosurgery, School of Medicine, Wonkwang University) ;
  • Kim, Hyun-Jung (Department of Internal Medicine, School of Medicine, Wonkwang University) ;
  • Lee, Chang-Hoon (Department of Internal Medicine, School of Medicine, Wonkwang University) ;
  • Ahn, Ho-Seon (Department of Internal Medicine, School of Medicine, Wonkwang University) ;
  • Lee, Ji-Eun (Department of Internal Medicine, School of Medicine, Wonkwang University) ;
  • Kim, Jeong-Joong (Department of Anatomy, School of Medicine, Wonkwang University) ;
  • Choi, Min-Kyu (Department of Anatomy, School of Medicine, Wonkwang University)
  • 김윤경 (원광대학교 약학대학 한약학과) ;
  • 최윤홍 (원광대학교 약학대학 의과대학 해부학교실) ;
  • 송정훈 (원광대학교 약학대학 성형외과학교실) ;
  • 장성조 (원광대학교 약학대학 신경외과학교실) ;
  • 김현정 (원광대학교 약학대학 내과학교실) ;
  • 이창훈 (원광대학교 약학대학 내과학교실) ;
  • 안선호 (원광대학교 약학대학 내과학교실) ;
  • 이지은 (원광대학교 약학대학 내과학교실) ;
  • 김정중 (원광대학교 약학대학 의과대학 해부학교실) ;
  • 최민규 (원광대학교 약학대학 의과대학 해부학교실)
  • Published : 2009.12.25
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Abstract

We have previously shown that water extract of deer antler (WEDA) inhibited RANKL-mediated osteoclast differentiation from bone marrow macrophages by suppressing c-Fos and NFATc1 expression. Thus, we examined the effect of WEDA in inflammation-induced bone loss in vivo. Here we found that WEDA inhibited osteoblast-supported osteoclast differentiation induced by lipopolysaccharide (LPS). However, WEDA did not suppress the expression of receptor activator of NF-${\kappa}B$ ligand (RANKL) in response to LPS in osteoblasts. WEDA also inhibited the bone resorptive activity of mature osteoclasts. To examine the effect of WEDA on bone loss, when LPS injected subcutaneously in mice, bone loss was greatly increased, but WEDA treatment inhibited LPS-mediated bone loss. Taken together, we conclude that WEDA inhibited osteoclast differentiation and bone resorption in vitro and in vivo. Thus WEDA may be useful in the treatment of bone-related disorders.

Keywords

References

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