Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Swimming Exercise Training and Gastrodia Elata Blume Extract Administration on Oxidative Enzyme Activity in Streptozotocin-induced Diabetic Rat

수중운동과 천마(天麻) 추출물 투여가 streptozotocin으로 유도한 백서의 산화적 효소에 미치는 영향

  • Published : 2009.12.25
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of the present study was to evaluate the possibility of protective effectness of swimming exercise and Gastrodia elata blume oral administration against beta-cell damage in streptozotocin (STZ)-induced diabetes in rats. The animals were divided into five groups: the normal group(n=10), the STZ-induced diabetes group(n=10), the STZ-induced diabetes and moderate-intensity exercise group(n=10), the STZ-induced diabetes Gastrodia elata blume(300 mg/kg) oral administration group(n=10), the STZ-induced diabetes and moderate-intensity exercise and Gastrodia elata blume(300 mg/kg) oral administration group(n=10). Animals in the exercise groups were made to swim moderate swimming exercise protocols once a day for 4 consecutive weeks. Serum glucose concentration and insulin level, superoxide dismutase (SOD) and catalase (CAT) were measured in serum. Swimming exercise and Gastrodia elata blume extract administration has shown anti-diabetic effect probably through decreasing serum glucose and insulin level and increasing antioxidant enzyme activity.

Keywords

References

  1. Baynes, J.W., Thorpe, S.R. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes. 48(1):1-9, 1999 https://doi.org/10.2337/diabetes.48.1.1
  2. Baynes, J.W. Role of oxidative stress in development of complications in diabetes. Diabetes, 40: 405-412, 1991 https://doi.org/10.2337/diabetes.40.4.405
  3. Brownlee, M. Advanced protein glycosylation in diabetes and aging. Ann Rev Med. 46: 223-234, 1996 https://doi.org/10.1146/annurev.med.46.1.223
  4. Vlassara, H. Recent progress in advanced glycation end products and diabetic complications. Diabetes. 46(Suppl. 2): 19-25, 1997 https://doi.org/10.2337/diabetes.46.1.19
  5. Ishii, H., Daisuke, K., King, G.L. Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. J Mol Med. 76(1):21-31, 1998 https://doi.org/10.1007/s109-1998-8101-y
  6. Witztum, J.L. Role of modified lipoproteins in diabetic macroangiopathy. Diabetes. 46(Suppl. 2):112-114, 1997 https://doi.org/10.2337/diab.46.2.S112
  7. Sharma, K., Ziyadeh, F.N. Biochemical events and cytokine interactions linking glucose metabolism to the development of diabetic nephropathy. Sem Nephrol 17(2):80-92, 1997
  8. Hamada, Y., Fujii, H., Fukagawa, M. Role of oxidative stress in diabetic bone disorder. Bone. 45(1):35-38, 2009 https://doi.org/10.1016/j.bone.2009.02.004
  9. Michikawa, M., Lim, K.T., Mclamon, J.G., Kim, S.U. Oxygen radical-induced neurotoxicity in spinal cord neuron cultures. J Neurosci Res. 37(1):62-70, 1994 https://doi.org/10.1002/jnr.490370109
  10. Delp, M.D. Effects of exercise training on endotheliumdependent peripheral vascular responsiveness. Med Sci Sports Exerc. 27(8):1152-1157, 1995
  11. Walker, K.Z., Piers, L.S., Putt, R.S., Jones, J.A., O'Dea, K. Effects of regular walking on cardiovascular risk factors and body composition in normoglycemic women and women with type 2 diabetes. Diabetes Care. 22(4):555-561, 1999 https://doi.org/10.2337/diacare.22.4.555
  12. Boule, N.G., Kenny, G.P., Haddad, E., Wells, G.A., Sigal, R.J. Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus. Diabetologia. 46(8):1071-1081, 2003 https://doi.org/10.1007/s00125-003-1160-2
  13. Sessa, W.C., Pritchard, K., Seyedi, N., Wang, J., Hintze, T.H. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res. 74(2):349-353, 1994 https://doi.org/10.1161/01.RES.74.2.349
  14. 堀田滿. 世界有用植物圖鑑. 東京, 平凡社, p 476, 1988
  15. 李尙仁. 本草學. 서울, 修書院, p 232, 1981
  16. 吳普. 神農本草經, 北京. 人民衛生出版社, p 288, 1982
  17. 중약대사전편찬위원회. 중약대사전. 정담출판사, 서울, pp 4105-4110, 1997
  18. Lee, B.Y., Yang, Y.M., Han, C.K. Analysis of the aroma pattern of Gastrodia Rhizoma by the drying condition. J Korean Soc Food Sci Nutr. 34: 13-17, 2002 https://doi.org/10.3746/jkfn.2005.34.1.013
  19. 박성혜, 조좌형, 안병용. 천마의 식품학적 활용을 위한 기초연구. J East Asian Soc Dietary Life. 17(4):554-562, 2007
  20. 홍희도, 김영찬, 금인경, 김성수, 김경임, 한찬규. 천마 분획물이 고지방식이를 급여한 흰쥐의 혈청 지질농도에 미치는 영향. 한국응용생명화학회지 48(4):370-374, 2005
  21. 허진철, 박자영, 안상미, 이진만, 윤치영, 신흥묵, 권택규, 이상한. 천마추출물의 항산화 및 항암 활성. 한국식품저장유통학회지 13(1):83-87, 2006
  22. Seong, J.Y., Ju, R.K. Chae, K.L., Jeong, E.H., Jae, H.L. Gastrodia elata blume and an active component, p-hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant realated gene expressions. Biol pharm Bull. 28(6):1016-1020, 2005 https://doi.org/10.1248/bpb.28.1016
  23. Ha, J.H., Lee, D.U., Eah, K.Y., Hah, J.S., Kim, H.J., Young, C.S., Huh, K. Modulation of ligand binding to the GABAbenzodiazepine receptor complex by Gastrodia elata Blume. The Journal of Applied Pharmacology. 5: 325-330, 1997
  24. Kim, H.J., Kang, W.W., Moon, K.D. Quality characteristics of bread added with Gastrodia elata Blume powder. Korean J Food Sci Technol. 33: 437-443, 2001
  25. Kang, T.S., Kong, Y.J., Kwon, H.J., Choi, B.K., Hong, J.G., Park, Y.K. A studies on the chemical composition and in vitro biological activities of a hot water extracts of Gastrodia elata. The Korean Journal of Mycology. 30: 136-141, 2002 https://doi.org/10.4489/KJM.2002.30.2.136
  26. Gobatto, C.A., De Mello, M.A., Sibuya, C.Y., De azevedo, J.R., Dos santos, L.A., Kokubun, E. Maximal lactate steady state in rats submitted to swimming exercise. Comp Biochem Physiol A Mol Integr Physiol. 130(1):21-27, 2001 https://doi.org/10.1016/S1095-6433(01)00362-2
  27. Marier, C.M., Chan, P.H. Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. Neuroscientist. 8(4):323-334, 2002 https://doi.org/10.1177/107385840200800408
  28. Johansson, L.H., Borg, L.A. A spectrophotometric method for determination of catalase activity in small tissue samples. Anal Biochem. 174(1):331-336, 1988 https://doi.org/10.1016/0003-2697(88)90554-4
  29. Pak, J.W., Herbst, A., Bua, E., Gokey, N., McKenzie, D., Aiken, J.M. Rebuttal to Jacobs: the mitochondrial theory of aging: alive and well. Aging Cell. 2(1):9-10, 2003 https://doi.org/10.1046/j.1474-9728.2003.00037.x
  30. Freeman, B.A., Crape, J.D. Biology of disease: free radicals and tissue injury. Lab Invest. 47(5):412-426, 1982
  31. Hong, J., Bose, M., Ju, J., Ryu, J.H., Chen, X., Sang, S., Lee, M.J., Yang, C.S. Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis. 25(9): 1671-1679, 2004 https://doi.org/10.1093/carcin/bgh165
  32. Anwer, T., Sharma, M., Pillai, K.K., Haque, S.E., Alam, M.M., Zaman, M.S. Proctective effect of bezafibrate on streptozotocin-induced oxidative stress and toxicity in rats. Toxicology. 229(1):165-172, 2007 https://doi.org/10.1016/j.tox.2006.10.016
  33. 김경임, 한찬규, 성기승, 이옥환, 박정민, 이부용. 천마 분말, 에탄올 및 열수추출물이 고지방식이를 급여한 흰쥐의 혈청지질과 체지방에 미치는 영향. 한국식품과학회지 35(4):720-725, 2003
  34. Coskun, O., Kanter, M., Korkmaz, A., Oter, S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res. 51(2):117-123, 2005 https://doi.org/10.1016/j.phrs.2004.06.002
  35. Gomes, R.J., Leme, J.A., de Moura, L.P., de Araújo, M.B., Rogatto, G.P., de Moura, R.F., Luciano, E., de Mello, M.A. Growth factors and glucose homeostasis in diabetic rats: effects of exercise training. Cell Biochem Funct. 27(4):199-204, 2009 https://doi.org/10.1002/cbf.1556
  36. Borrello, S., Seccia, A., Galeotti, T., Bartoli, G.M., Farallo, E., Serri, F. Protective enzymes in human epidermal carcinomas and psoriasis. Arch Dermatol Res. 276(5):338-340, 1984 https://doi.org/10.1007/BF00404630
  37. Jenkins, R.R. Free radical chemistry; Relationship to exercise. Sports medicine. 5: 156-170, 1988 https://doi.org/10.2165/00007256-198805030-00003
  38. Kostic, N., Caparevic, Z., Marina, D., Ilic, S., Radojkovic, J., Cosic, Z., Bakic-Celic, V. Clinical evaluation of oxidative stress in patients with diabetes mellitus type II impact of acute exercise. Vojnosanit Pregl. 66(6):459-464, 2009 https://doi.org/10.2298/VSP0906459K
  39. Yokota, T., Kinugawa, S., Hirabayashi, K., Matsushima, S., Inoue, N., Ohta, Y., Hamaguchi, S., Sobirin, M.A., Ono, T., Suga, T., Kuroda, S., Tanaka, S., Terasaki, F., Okita, K., Tsutsui, H. Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 297(3):1069-1077, 2009 https://doi.org/10.1152/ajpheart.00267.2009