Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Safety of Prescribed Korean Herbal Medicine on Liver Function : Prospective Multi-center Pilot Study

한약 복용이 간기능에 미치는 영향 : 전향적 다기관 예비연구

  • Yun, Young-Ju (Division of Standard Research. Korea Institute of Oriental Medicine) ;
  • Park, Jae-Heon (Department of Neuropsychiatry, College of Oriental Medicine, WonkWang University) ;
  • Paeck, Eun-Kyung (Haema Traditional Korean Medical Clinic) ;
  • Park, Jae-Hyung (Haema Traditional Korean Medical Clinic) ;
  • Jeong, Seul-Ki (Myungsung Traditional Korean Medical Clinic) ;
  • Park, Hae-Mo (Department of Preventive Medicine, College of Oriental Medicine, Sangji University) ;
  • Lee, Sun-Dong (Department of Preventive Medicine, College of Oriental Medicine, Sangji University) ;
  • Shin, Byung-Cheul (Department of Oriental Rehabilitation Medicine, School of Oriental Medicine, Pusan National University)
  • 윤영주 (한국한의학연구원 표준화연구본부) ;
  • 박재현 (원광대학교 한의과대학 한방신경정신과) ;
  • 백은경 (해마한의원) ;
  • 박재형 (해마한의원) ;
  • 정슬기 (명성한의원) ;
  • 박해모 (상지대학교 한의과대학 예방의학) ;
  • 이선동 (상지대학교 한의과대학 예방의학) ;
  • 신병철 (부산대학교 한의학전문대학원 한방재활의학과)
  • Published : 2009.06.25
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Abstract

The aim of this study was to investigate the safety of short-term use of Korean herbal medicine (KHM; prescribed herbal medicine by doctors of traditional Korean medicine) on liver function. Three hundred eighty four outpatients who took KHM for various conditions were enrolled for multi-center, prospective observational study. Of them 237 patients completed questionnaire and were checked liver function (aspartic aminotransferase;AST, alanine aminotransferase;ALT, alkaline phosphatase;ALP, total bilirubin;t-Bil, direct bilirubin;d-Bil, gamma glutamyltranspeptidase;GGT, protein and albumin) before and after taking KHM (duration; 21.4${\pm}$10.0 days), and data were analysed statistically. Of the 213 patients showing normal liver function test (LFT) at baseline, 209 (98.1%) remained within the normal range at the second test while 3 (1.4%) revealed slight increase of LFT. Only one subject had raised LFT regarding level of liver injury without perceived symptoms. Twenty-four of 237 patients were abnormal at baseline, and 16 at the second testing. Of the patients taking KHM, only 4 changed from normal to abnormal while 12 from abnormal to normal in their LFT. There were no significant increase in LFT level between the first and second test, except in the t-Bil level, however, the change of t-Bil was small and within normal range. The current study showed that the use of KHM did not increase the frequency of abnormal LFTs, at least in the short term.

Keywords

References

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