Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Characterization of Angiogenesis Inhibitor Effect of Green Tea Seed Extract

  • Hwang, Jae-Ho (Eco Marine Bio Center, Chonnam National University) ;
  • Lee, Sung-Hoon (Division of Fisheries & Ocean Sciences, Chonnam National University) ;
  • Rha, Sung-Ju (Eco Marine Bio Center, Chonnam National University) ;
  • Yoon, Ho-Seop (Division of Fisheries & Ocean Sciences, Chonnam National University) ;
  • Shin, Jin-Hyuk (Department of Biotechnology) ;
  • Lee, Jin-Hee (Division of Fisheries & Ocean Sciences, Chonnam National University) ;
  • Seo, Myeong-Jin (Department of Biotechnology) ;
  • Kang, Kyeong-Wan (Division of Fisheries & Ocean Sciences, Chonnam National University) ;
  • Han, Kyeong-Ho (Division of Fisheries & Ocean Sciences, Chonnam National University) ;
  • Kim, Yong-Joo (Division of Fisheries & Ocean Sciences, Chonnam National University) ;
  • Kho, Kang-Hee (Eco Marine Bio Center, Chonnam National University) ;
  • Kim, Seon-Jae (Eco Marine Bio Center, Chonnam National University) ;
  • Shin, Tai-Sun (Eco Marine Bio Center, Chonnam National University)
  • Published : 2009.06.30
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Abstract

Green tea seed was extracted with absolute ethanol,and the green tea seed extract(GTSE)was subjected to assays for toxicity, antioxidant ability, angiogenesis inhibitory effects and cell adhesion, as well as western blotting, and an in vivo experiment against 4 high-ranking adult cancers in Korea. Our series of experimental data demonstrated that GTSE has an antioxidant ability superior to that of EGCG in the green tea leaf, and also exhibits a profound high tumor growth inhibitory activity on a variety of cancer cell lines, as well as nude mice infected with cancer cells. GTSE was identified as a natural anticancer compound showing excellent angiogenesis inhibition and cancer cell suppression abilities. Our preliminary observations also indicate that GTSE may be another potential source of natural dietary antioxidants and also may be applicable as a novel natural anticancer agent.

Keywords

References

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