Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Anti-mechanical Hyperalgesic Effect of Lonicera Japonica in Neuropathic Pain Rats

  • Hwang, Hye-Jeong (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kim, Hee-Young (Department of Neuroscience and Cell Biology, University of Texas Medical Branch) ;
  • Lee, Hye-Jung (Department of Meridian and Acupuncture, College of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Bae-Hwan (Medical Research Center and Brain Research Institute, Yonsei University College of Medicine) ;
  • Shim, In-Sop (Department of Integrated Medicine, College of Medicine, The Catholic University)
  • Published : 2009.08.25
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Abstract

Lonicera japonica has been widely used for chronic inflammatory diseases in many Asian countries. Its analgesic effect has not been explored yet. This study aimed to test the analgesic potential of methanol extracts from Lonicera japonica (MELJ) in rat neuropathic mctel. Neuropathic pain was pacts ed by partial sciatic nerve injury. Two weeks after surgery, neuropathic rats received oral administration of MELJ at doses of either 0.0 g/kg, 0.2 g/kg or 0.4 g/kg. At dose of 0.0 g, rats were administered with saline only and used as conracl. The behavioral tests for f 0.0 g, raand ccld hs were adma were weformed up to 2 hours after treatment. The MELJ at the dose 0.4 g/kg dmg gfg, ntly alleviated f 0.0 g, rahyperalgesia, but not cold hyperalgesia. These results showed that the MELJ had, although transient, analgesic effect on mechanical hyperalgesia in the rat neuropathic model.

Keywords

References

  1. Abbadie, C., Lombard, M.C., Besson, J.M., Trafton, J.A., Basbaum, A.I. Mu and delta opioid receptor-like immunoreau and dein the cerndcal spinal cord of theomba after dorsal rhizotomy or neonatal caps Tcin: an analysis of pre- and postsynapt Lomeceptor distributions: Br Tr Res 930: 150-162, 2002 https://doi.org/10.1016/S0006-8993(02)02242-4
  2. Ballantyne, J.C., Mao, J. Opioid therapy for chronic pain: N Engl J Med 349: 1943-1953, 2003 https://doi.org/10.1056/NEJMra025411
  3. Bhargava, H.N., Ramarao, P. The effect of Panax ginseng on the development of tolerance to the pharmacological actions of morphine in the rat: Gen Pharmacol 22: 521-525, 1991 https://doi.org/10.1016/0306-3623(91)90017-Z
  4. Bridges, D., Thompson, S.W., Rice, A.S. Mechanisms of neuropathic pain: Br J Anaesth 87: 12-26, 2001 https://doi.org/10.1093/bja/87.1.12
  5. Chang, C.W., Lin, M.T., Lee, S.S., Karin, C.S., Hsu, F.L., Lin, J.Y. Differential inhibition of reverse transcriptase and cellular DNA polymerase -alpha activity by lignans isolated from Chinese herbs, Phyhllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix: Antiviral Research 27: 367-374, 1995 https://doi.org/10.1016/0166-3542(95)00020-M
  6. Chung, J.M., Na, H.S. Effects of system morphine on neuropathic pain behaviors in an experimental rat model: Analgesia 2: 151-155, 1996
  7. da Silva, K.L., dos Santos, A.R., Mattos, P.E., Yunes, R.A., Delle-Monache, F., Cechinel-Filho, V. Chemical composition and analgesic activity of Calophyllum brasiliense leaves: Therapie 56: 431-434, 2001
  8. Dellemin, P. Are opioids effective in relieving neuropathic pain?: Pain 80: 453-462, 1999 https://doi.org/10.1016/S0304-3959(98)00256-5
  9. Deraniyagala, S.A., Ratnasooriya, W.D., Goonasekara, C.L. Antinociceptive effect and toxicological study of the aqueous bark extract of Barringtonia racemosa on rats: J Ethnopharmacol 86: 21-26, 2003 https://doi.org/10.1016/S0378-8741(03)00015-1
  10. Huang, K.C. The pharmacology of Chinese herbs. ed. CRC press. 1993
  11. Jensen, T.S., Finnerup, N.B. Management of neuropathic pain: Curr Opin Support Palliat Care, 1: 126-131, 2007 https://doi.org/10.1097/SPC.0b013e3282eeb45f
  12. Kwak, W.J., Han, C.K., Chang, H.W., Kim, H.P., Kang, S.S., Son, K.H. Loniceroside C, an anti-inflammatory saponin from Lonicera japonica: Chem Pharm Bull 51: 333-335, 2003 https://doi.org/10.1248/cpb.51.333
  13. Lee, B.H., Won, R., Baik, E.J., Lee, S.H., Moon, C.H. An animal model of neuropathic pain employing injury to the sciatic nerve branches: Neuroreport 11: 657-661, 2000 https://doi.org/10.1097/00001756-200003200-00002
  14. Lee, J.H., Ko, W.S., Kim, Y.H., Kang, H.S., Kim, H.D., Choi, B.T. Antiinflammatory effect of the aqueous extract from Loncera japonica flower is related to inhibition of NF KappaB activation through reducing I-kappaBalpha degradation in rat liver: Int J Mol Med 7: 79-83, 2001
  15. Mogil, J.S., Shin, Y.H., McCleskey, E.W., Kim, S.C., Nah, S.Y. Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice: Brain Res 792: 218-228, 1998 https://doi.org/10.1016/S0006-8993(98)00133-4
  16. Nabata, H., Saito, H., Tagagi, K. Pharmacological studies of neutral saponins (GNS) of Panax ginseng root: Jpn J Pharmacol 23: 29-41, 1973 https://doi.org/10.1254/jjp.23.29
  17. Nemmani, K.V., Ramarao, P. Ginsenoside Rf potentiates U-50,488H-induced analgesia and inhibits tolerance to its analgesia in mice: Life Sci 72: 759-768, 2003 https://doi.org/10.1016/S0024-3205(02)02333-0
  18. Peng, L.Y., Mei, S.X., Jiang, B., Zhou, H., Sun, H.D. Constituents from Lonicera japonica: Fitoterapia 71: 713-715, 2000 https://doi.org/10.1016/S0367-326X(00)00212-4
  19. Tae, J., Han, S.W., Yoo, J.Y., Kim, J.A., Kang, O.H., Baek, O.S., Lim, J.P., Kim, D.K., Kim, Y.H., Bae, K.H., Lee, Y.M. Antiinflammatory effect of Lonicera japonica in proteinase-activated receptor 2-mediated paw edema: Clinica Chimica Acta 330: 165-171, 2003 https://doi.org/10.1016/S0009-8981(03)00017-2
  20. Vongtau, H.O., Amos, S., Binda, L., Kapu, S.D. Gamaniel, K.S., Kunle, O.F., Wambebe, C. Pharmacological effects of theaqueous extract of Neorautanenia mitis in rodents: J Ethnopharmacol 72: 207-214, 2000 https://doi.org/10.1016/S0378-8741(00)00247-6
  21. Wei, F., Zou, S., Young, A., Dubner, R., Ren, K. Effects of four herbal extracts on adjuvant-induced inflammation and hyperalgesia in rats: J Altern Complement Med 5: 429-436, 1999 https://doi.org/10.1089/acm.1999.5.429