Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Water Extract of Schisandra Chinensis on Osteoclast Differentiation

오미자 물 추출물이 파골세포 분화에 미치는 영향

  • Lee, Yan (Department of Anatomy, School of Medicine, School of Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Hanbang Body-fluid Research Center, College of Oriental Medicine, School of Medicine, Wonkwang University) ;
  • Jang, Sung-Jo (Department of Neurosurgery, School of Medicine, School of Medicine, Wonkwang University) ;
  • Song, Jeong-Hoon (Plastic & Rconstructive Surgery, School of Medicine, Wonkwang University)
  • 리연 (원광대학교 의과대학 해부학교실) ;
  • 이호섭 (원광대학교 한의과대학 한방체액연구센터) ;
  • 장성조 (원광대학교 의과대학 신경외과학교실) ;
  • 송정훈 (원광대학교 의과대학 성형외과학교실)
  • Received : 2010.09.14
  • Accepted : 2010.10.11
  • Published : 2010.10.25
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Abstract

Bone maintains its homeostasis through balance between bone resorbing osteoclasts and bone forming osteoblasts. Thus, unusual balance between osteoclasts and osteoblasts leads to pathological bone diseases, such as osteoporosis, rheumatoid arthritis, autoimmune arthritis, periodontitis. Schisandra chinensis well known traditional herbal has been used for treatment of diseases in China, Korea, Japan, andothers. Recently, research studies have demonstrated that the lignans found in Schisandra chinensis stimulate osteoblasts and suggest that it may be helpful against osteoporosis. However, the inhibitory effect of water extract of Schisandra chinensis on osteoclast differentiation remains largely unknown. In this study, Water extract of Schisandra chinensis markedly suppressed RANKL-induced osteoclast differentiation in cultures of BMMs without cytotoxicity. The mRNA expression of c-Fos, NFATc1, and TRAP induced by RANKL was inhibited by water extract of Schisandra chinensis. It also suppressed c-Fos and NFATc1 protein expression. Taken together, these results suggest that water extract of Schisandra chinensis has the potential to serve as a treatment of bone disease such as osteoporosis.

Keywords

References

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