Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Antioxidant Effects and Anti-inflammation Effects of Lophatheri Herba Water Extracts Via Reducing iNOS Synthesis Induced by LPS in RAW 264.7 Cell

담죽엽의 항산화 효과와 RAW 264.7 세포에서 LPS로 유도된 iNOS 발현에 미치는 영향

  • Hwang, Sung-Yeoun (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Sung-Won (Department of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University) ;
  • Kwon, Kang-Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Choi, Won-Jong (Department of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Jae-Hyo (Department of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University) ;
  • Ahn, Seong-Hun (Department of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University)
  • 황성연 (원광대학교 한의과대학 본초학교실) ;
  • 이성원 (원광대학교 한의과대학 경혈학교실) ;
  • 권강범 (원광대학교 한의과대학 한방생리학교실) ;
  • 최원종 (원광대학교 한의과대학 경혈학교실) ;
  • 김재효 (원광대학교 한의과대학 경혈학교실) ;
  • 안성훈 (원광대학교 한의과대학 경혈학교실)
  • Received : 2010.11.16
  • Accepted : 2010.12.09
  • Published : 2010.12.25
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Abstract

We studied to know the anti-inflammation effect on water extracts of Lophatheri Herba which was growing in every places in our country. We objected free radical scanvenger effect and nitrite eliminate effect of the Lophatheri Herba water extracts, and the cell viabillity, the effects of Lophatheri Herba water extracts on NO production, iNOS synthesis induced by LPS. Free radical scavenger effects were $27.91{\pm}0.12%$, $38.96{\pm}0.10%$, $46.22{\pm}0.15%$ depend on 0.5, 1.0, 2.0 mg/ml each dose of Lophatheri Herba water extracts. Nitrite eliminate effects were $9.86{\pm}0.3%$, $80.61{\pm}0.23%$, $97.62{\pm}0.56%$ in 0.1, 1.0, 2.0 mg/ml Lophatheri Herba water extracts on pH 1.2. NO production and iNOS synthesis induced by LPS were reduced in RAW 264.7 cell by Lophatheri Herba water extracts. As the above results, Lophatheri Herba water extracts have anti-inflammation effects via NO production decrease, iNOS synthesis decrease mechanism. So Lophatheri Herba water extracts will be used as the protection or treatment in chronic inflammation desease like a asthma, stomatitis etc.

Keywords

References

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