Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Neural Mechanisms Underlying Antidepressant-Like Effects of Glycyrrhizae Radix in Rats

  • Park, Hyun-Jung (Department of Integrative Medicine and Research Center of Behavioral Medicine, College of Medicine, The Catholic University) ;
  • Shim, Hyun-Soo (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Shim, In-Sop (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Lee, Tae-Hee (Department of Formulae Pharmacology, College of Oriental Medicine, The Kyungwon University)
  • Received : 2010.08.26
  • Accepted : 2010.10.20
  • Published : 2010.12.25
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Abstract

Glycyrrhizae radix (GR) is an herbal medicine commonly used in East Asia for treating a variety of diseases, including stomach disorders. In this study, the antidepressant-like activity of GR was investigated using the forced swimming test (FST) in rats. After the FST, the expression of c-Fos and corticotrophin releasing factor (CRF) was assessed by immunochemistry of brain samples from the paraventricular nucleus of the hypothalamus (PVN). The results of the FST showed that a high dose (400 mg/kg) of extract was very effective in reducing immobility(P<0.01), and increased climbing. In addition, treatment with GR (400 mg/kg) significantly decreased the expression of c-Fos and CRF in the PVN, compared to controls. In conclusion, the findings of this study demonstrated that GR effectively reduced behavioral and physiological depression responses in an animal model of depression, suggesting that GR might be useful in the treatment of clinical depression.

Keywords

References

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