The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Gender-Related Differences in a Process of the Age-Dependent Alterations of the Elements in Monkey Sino-Atrial Node

  • Satoh, Hiroyasu (Department of Pharmacology, Division of Molecular and Cellular Biology, Chiang Mai University) ;
  • Tohno, Setsuko (Department of Anatomy, Faculty of Medicine, Chiang Mai University) ;
  • Minami, Takeshi (Laboratory of Environmental Biology, Department of Life Science, Faculty of Science and Engineering, Kinki University) ;
  • Oishi, Takao (Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University) ;
  • Hayashi, Motoharu (Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University) ;
  • Tohno, Yoshiyuki (Department of Anatomy, Faculty of Medicine, Chiang Mai University)
  • Received : 2010.04.08
  • Accepted : 2010.09.05
  • Published : 2010.10.31
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Abstract

Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day- to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were $-0.178{\pm}0.081$ (p<0.05) and $-0.088{\pm}0.022$ (p<0.05) in male (n=30), and $-0.095{\pm}0.026$ (p<0.05) and $-0.069{\pm}0.017$ (p<0.05) in female (n=30), respectively. The age-dependent coefficients for Fe/Ca, Zn/Ca, Fe/P, Fe/S, Zn/S, Fe/Mg and Zn/Mg were exhibited markedly in male, but all was less in female. In gender-related differences, only a ratio of P/Ca (p<0.05) was significantly observed with ageing. The trace elements such as Cu, Se and Sn were less detected in the SA nodes. These results indicate that the age-dependent changes in the ratios of elements are appeared more rapidly in male monkey SA node, and the gender difference is observed in ratio of P/Ca. The different attenuations may be involved with the age- and gender-related SA nodal functions.

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References

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