Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Apoptosis Induction of MCF-7 Human Breast Carcinoma Cells by Butein

Butein에 의한 MCF-7 유방암 세포의 세포사멸에 의한 항암 효과

  • Song, Ba-Da (Department of Preventive Meidicine, Cancer Preventive, Kyung Hee University) ;
  • Kim, Sun-Rye (Department of Preventive Meidicine, Cancer Preventive, Kyung Hee University) ;
  • Kim, Sung-Hun (Material Development Research Center, College of Oriental Medicine, Kyung Hee University) ;
  • Shin, Yong-Cheol (Department of Preventive Meidicine, Cancer Preventive, Kyung Hee University) ;
  • Ko, Seong-Gyu (Department of Preventive Meidicine, Cancer Preventive, Kyung Hee University)
  • 송바다 (경희대학교 한의과대학 예방의학교실) ;
  • 김순례 (경희대학교 한의과대학 예방의학교실) ;
  • 김성훈 (경희대학교 한의과대학 암예방소재개발센터) ;
  • 신용철 (경희대학교 한의과대학 예방의학교실) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실)
  • Received : 2010.04.26
  • Accepted : 2010.06.04
  • Published : 2010.06.25
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Abstract

Butein(3,4,2',4-tetrahydroxychalcone) has been reported anticancer effects in several cancer type, which is prostate, bladder cancer but breast cancer is not. This study was to investigate the antiproliferative effects by butein(3,4,2',4-tetrahydroxychalcone) in MCF-7 human breast carcinoma cells. We invastigated the effects of dose-dependently cell growth inhibition by butein, which could be proved by WST-1 assay. Also, flow cytometry analysis was butein increase percentage of subG1 phase. As well as, butein induces apoptosis through the expression of caspase-8,-3 and poly(ADP-ribose) polymerase(PARP) activation but not in DMSO treated cells. Taken together, this results suggest that butein induced MCF-7 apoptosis through extrinsic pathway and thus may have potential tumor suppressor in breast cancer.

Keywords

References

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