Protective Effects of Yijin-tang-gamibang Aqueous Extracts on Reflux Esophagitis Mediated by Antioxidant Defense Systems

이진탕가미방(二陳湯加味方)의 항산화 효과를 통한 역류성 식도염 억제효과

  • Park, Kyung (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Haany Univercity) ;
  • Kwak, Min-A (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Haany Univercity) ;
  • Kim, Dae-Jun (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Haany Univercity) ;
  • Byun, Joon-Seok (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Haany Univercity)
  • 박경 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 곽민아 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 김대준 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 변준석 (대구한의대학교 한의과대학 비계내과학교실)
  • Received : 2010.03.04
  • Accepted : 2010.05.28
  • Published : 2010.06.25

Abstract

The object of this study was to observe the protective effects of Yijin-tang-gamibang (YJGMB), Yijin-tang has been traditionally used in the Korean Medicine for treating various digestive diseases. The study showed that it is effective on reflux esophagitis induced by pylorus and forestomach ligation in rats. Three different dosages of YJGMB extracts, 200, 100 and 50 mg/kg, were orally pretreated, once a day for 28 days before pylorus and forestomach ligation. Seven groups, each of 8 rats per group were used in the present study. The results were compared with omeprazole, antioxidant and proton pump inhibitor, 30 and 10 mg/kg treated group. YJGMB 200 mg/kg were showed similar protective effects as compared with 30 mg/kg of omeprazole but more favorable effects were observed in 200, 100 and 50 mg/kg of all YJGMB treated rats as compared with omeprazole 10 mg/kg in the present study. In addition, YJGMB 200 mg/kg were showed more favorable antioxidant effects as compared with 30 mg/kg of omeprazole in the present study. Detail mechanism studies should be conduced in future with the screening of the biological active chemical compounds in herbs.

Keywords

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