Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-inflammatory Effects of Effective Microorganism Fermentation Substance on Atopic Dermatitis-like NC/Nga Mouse Model

아토피 피부염 유사 NC/Nga 마우스 모델에서 유용 미생물 발효물질의 항염증효과

  • Mok, Ji-Ye (Jeonju University Atopy & Health Research Institute) ;
  • Jeong, Seung-Il (Jeonju Biomaterials Institute) ;
  • Cho, Jung-Keun (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Choi, Ji-Won (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Nam, Sang-Yun (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Chang, Won-Ghil (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Moon, Byung-Eun (Evermiracle Research Institute) ;
  • Park, Kwang-Hyun (Department of Biochemistry, Chonbuk National University Medical School) ;
  • Jang, Seon-Il (Jeonju University Atopy & Health Research Institute)
  • 목지예 (전주대학교 아토피.건강전문연구소) ;
  • 정승일 (전주생물소재연구소) ;
  • 조정근 (전주대학교 대체의학대학) ;
  • 최지원 (전주대학교 대체의학대학) ;
  • 남상윤 (전주대학교 대체의학대학) ;
  • 장원길 (전주대학교 대체의학대학) ;
  • 문병은 (에버미라클 부설연구소) ;
  • 박광현 (전북대학교 의학전문대학원 생화학교실) ;
  • 장선일 (전주대학교 아토피.건강전문연구소)
  • Received : 2010.03.08
  • Accepted : 2010.04.12
  • Published : 2010.04.25
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Abstract

Atopic dermatitis (AD) is a chronically relapsing pruritic inflammatory skin disease. To find new anti-inflammatory products for skin inflammatory disease such as AD and contact dermatitis, we produced the effective microorganism fermentation substance (EM-S) by fermentation of medicinal plants with effective microorganisms including photosynthetic bacteria, lactic acid bacteria and yeast, screened the effects of EM-S on NC/Nga model mice. Murine AD-like skin lesions were made by painting Dermatophagoides farinae (Df) extract. Topically applied EM-S significantly reduced clinical severity score, ear thickness and histological grade in AD-like NC/Nga mouse model by Df antigen sensitization. In addition, the serum IgE and Th2 chemokine levels (TARC/CCL17, MDC/CCL22 and CTACK/CCL27) were significantly reduced by EM-S. Futhermore, skin tissue expressions of Th2 chemokines were significantly reduced by EM-S. These results demonstrate that topical application of EM-S may be improve the AD-like skin lesion by suppressing IgE and Th2 chemokines.

Keywords

References

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