Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Anti-inflammatory Effect of Sohamhyung-tang in RAW 264.7 Cells

마우스 대식세포(RAW 264.7 cell)에 대한 소함흉탕(小陷胸湯)의 항염증효과

  • Kim, Jai-Eun (Cardiovascular Medical Research Center, College of Oriental Medicine, Dongguk University) ;
  • Yun, Hyun-Jeong (Cardiovascular Medical Research Center, College of Oriental Medicine, Dongguk University) ;
  • Choi, Dall-Yeong (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Park, Sun-Dong (Cardiovascular Medical Research Center, College of Oriental Medicine, Dongguk University)
  • 김재은 (동국대학교 한의과대학 심혈관계질환 천연물연구개발센터) ;
  • 윤현정 (동국대학교 한의과대학 심혈관계질환 천연물연구개발센터) ;
  • 최달영 (동국대학교 한의과대학 병리학교실) ;
  • 박선동 (동국대학교 한의과대학 심혈관계질환 천연물연구개발센터)
  • Received : 2009.12.18
  • Accepted : 2010.01.20
  • Published : 2010.02.25
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Abstract

Inflammation is a double-edge sword, functioning as a response against external stimuli, but excessive inflammation can lead to a harmful result. Inflammation is important in the development of vascular diseases, such as atherosclerosis and restenosis. Sohamhyung-tang(SHHT) is one of major herbal prescriptions from "Sanghanron", treating congested heat in thorax. It can be seen as an origin of several prescriptions for Hyungbi(胸痺, thoracic congestion), with its major component Trichosanthes semen. This study was done to determine whether SHHT reduces the production of nitrite, index of NO, and pro-inflammatory cytokines in Lipopolysaccharide(LPS)-induced RAW 264.7 cells. The results show that SHHT inhibited LPS-induced production of NO and PGE2, and iNOS and COX-2 expression, meaning SHHT has a significant anti-inflammatory effect. Based on these results, we suggest that SHTT can be used for prevention and treatment of diseases which starts from chronic inflammatory reactions.

Keywords

References

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