Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
권호 표지
DOI QR코드

DOI QR Code

Complete Resection of Pulmonary Metastatic Melanoma

  • Kim, Jae-Jun (Department of Thoracic and Cardiovascular Surgery, College of Medicine, The Catholic University of Korea) ;
  • Park, Jae-Kil (Department of Thoracic and Cardiovascular Surgery, College of Medicine, The Catholic University of Korea) ;
  • Wang, Young-Pil (Department of Thoracic and Cardiovascular Surgery, College of Medicine, The Catholic University of Korea)
  • Received : 2010.08.19
  • Accepted : 2011.02.08
  • Published : 2011.04.05
Download PDF
⟨ Previous Next ⟩

Abstract

Background: The prognosis of melanoma metastasized to other organs is very poor. There have been many studies on metastatic melanoma in Western society, but there have been few studies done in Korea because of the small number of cases. Materials and Methods: A retrospective review of 7 patients who underwent complete resection of pulmonary metastases from melanoma from January 2005 to December 2009 was performed. When the primary lesion was controlled or simultaneously controllable and no other metastatic lesion was found, pulmonary resections were performed. We analyzed the clinical prognoses after the initial melanoma diagnosis. Results: Of the seven patients, one was male and six were female. The mean age was 58.2 years (range 45~71). Six patients had a single pulmonary lesion and one patient had three lesions confined to the same lobe. The mean disease-free interval was 43.5 months (0~146 months). Before pulmonary resection, 4 patients had received systemic therapy. After pulmonary resection, 6 patients received systemic therapy. Complete resection was confirmed histologically. The metastasectomy was performed by wedge resection (6 patients) or lobectomy (1 patient). There were no mortalities or complications. After pulmonary resection, 1 patient had recurrent multiple lesions in the lung and 4 patients had metastases to other organs. The organs were the liver, brain, pleura, and lymph nodes. The mean observation time was 31.6 months and 3 patients died during observation. The mean survival was 27.7 months (14~60 months) and the 1-year and 3-year survival rates were 100% and 42%, respectively. Conclusion: When patients were selected carefully, the complete resection of pulmonary metastatic lesions was considered a major therapeutic tool.

Keywords

References

  1. Korean Ministry of Health and Welfare statistics, 2007.
  2. Jemal A, Murray T, Ghafoor A, Samuels A, Ward E. Cancer statistics, 2004. CA Cancer J Clin 2004;54:8-29. https://doi.org/10.3322/canjclin.54.1.8
  3. Wong SL, Coit DG. Role of surgery in patients with stage IV melanoma. Curr Opin Oncol 2004;16:155-60. https://doi.org/10.1097/00001622-200403000-00013
  4. Tafra L, Dale PS, Wanek LA, Ramming KP, Morton DL. Resection and adjuvant immunotherapy for melanoma metastatic to the lung and thorax. J Thorac Cardiovasc Surg 1995;110:119-29. https://doi.org/10.1016/S0022-5223(05)80017-0
  5. Young SE, Martinez SR, Essner R. The role of surgery in treatment of stage IV melanoma. J Surg Oncol 2006;94:344-51. https://doi.org/10.1002/jso.20303
  6. Yoon JK. Clinical application of 18F-FDG PET in malignant melanoma. Nucl Med Mol Imaging 2008;42:140-8.
  7. Conill C, Gimferrer JM, Marruecos J, et al. Clinical outcome after surgical resection of lung metastases from melanoma. Clin Transl Oncol 2007;9:48-52. https://doi.org/10.1007/s12094-007-0009-4
  8. Leo F, Cagini L, Rocmans P, et al. Lung metastases from melanoma: when is surgical treatment warranted? Br J Cancer 2000;83:569-72. https://doi.org/10.1054/bjoc.2000.1335
  9. Moon HS. Esophageal metastasis of malignant melanoma in a 66-year-old female patient. J Korean Geriatr Soc 2009;13:39-42. https://doi.org/10.4235/jkgs.2009.13.1.39
  10. Lee KN, Lee OY. A case of malignant melanoma metastasized to liver and gastrointestinal tract. Korean J Gastroenterol 2010;55:1-3. https://doi.org/10.4166/kjg.2010.55.1.1
  11. Essner R, Lee JH, Wanek LA, Itakura H, Morton DL. Contemporary surgical treatment of advanced-stage melanoma. Arch Surg 2004;139:961-7. https://doi.org/10.1001/archsurg.139.9.961
  12. Petersen RP, Hanish SI, Haney JC, et al. Improved survival with pulmonary metastasectomy: an analysis of 1720 patients with pulmonary metastatic melanoma. J Thorac Cardiovasc Surg 2007;133:104-10. https://doi.org/10.1016/j.jtcvs.2006.08.065
  13. Toba H, Kondo K, Kenzaki K, Miyoshi T, Sakiyama S, Tangoku A. Late pulmonary metastases from malignant melanoma of the left planta. Gen Thorac Cardiovasc Surg 2009;57:558-61. https://doi.org/10.1007/s11748-009-0438-9
  14. Andrews S, Robinson L, Cantor A, DeConti EC. Survival after surgical resection of isolated pulmonary metastases from malignant melanoma. Cancer Control 2006;13:218-23. https://doi.org/10.1177/107327480601300309
  15. Younes RN, Gross JL, Taira AM, Martins AAC, Neves GS. Surgical resection of lung metastases: results from 529 patients. Clinics 2009;64:535-41. https://doi.org/10.1590/S1807-59322009000600008
  16. Martinez SR, Young SE. A rational surgical approach to the treatment of distant melanoma metastases. Cancer Treat Rev 2008;34:614-20. https://doi.org/10.1016/j.ctrv.2008.05.003
  17. Dalrymple-Hay MJ, Rome PD, Kennedy RC, Fulham M, McCaughn BC. Pulmonary metastatic melanoma -- the survival benefit associated with positron emission tomography scanning. Eur J Cardiothorac Surg 2002;21:611-5. https://doi.org/10.1016/S1010-7940(02)00026-X
  18. Wargo JA, Tanabe K. Surgical management of melanoma. Hematol Oncol Clin North Am 2009;23:565-81. https://doi.org/10.1016/j.hoc.2009.03.002

Cited by

  1. Remarkable 23-year survival after bilateral thoracic melanoma metastasectomy vol.23, pp.4, 2011, https://doi.org/10.1177/0218492314534659
  2. Nivolumab induced pulmonary sarcoid-like granulomas with a concurrent pleural schwannoma: A pathologic-radiologic correlation of a rare condition mimicking metastatic melanoma vol.57, pp.None, 2011, https://doi.org/10.1016/j.anndiagpath.2021.151880