Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Skin Safety Evaluation of a Korean Traditional Prescription, Dansam-samul-tang and Samwhang-sasim-tang

한방 처방제인 단삼사물탕과 삼황사심탕의 피부적용제로의 활용을 위한 피부 안전성 평가 연구

  • Lee, In-Chul (Center for Senior Industry, Youngdong University) ;
  • Kim, Bae-Hwan (Department of Public Health, Keimyung University) ;
  • Kim, Sung-Ok (Department of Surgery and the Sealy Center for Cancer Cell Biology, University of Texas Medical Branch) ;
  • Kim, Mee-Kyung (Center for Senior Industry, Youngdong University)
  • 이인철 (영동대학교 고령친화산업 기업지원센터) ;
  • 김배환 (계명대학교 자연과학대학 공중보건학과) ;
  • 김성옥 (텍사스의과대학교 실리 암센터) ;
  • 김미경 (영동대학교 고령친화산업 기업지원센터)
  • Received : 2011.01.12
  • Accepted : 2011.04.05
  • Published : 2011.04.25
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Abstract

In traditional medicines, Dansam-samul-tang and Samwhang-sasim-tang extracts were known to effects of antioxidant and antimicrobial activity. To investigate the safety evaluation of skin, these extracts were measured to skin safety testing such as primary skin irritation test, eye irritation test and skin sensitization test. The results of the primary skin irritation test and eye irritation test in vitro showed that these extracts included in the nonirritating area. Skin sensitization test results by Guinea Pig Maximization (GPMA) indicated that there was no allergy reaction. Therefore, Dansam-samul-tang and Samwhang-sasim-tang extracts were very safe in every safety test of skin. These results suggests that Dansam-samul-tang and Samwhang- sasim-tang extracts in 1 % concentration can be useful cosmetic ingredients.

Keywords

References

  1. Chang, I.S., Lee, O.S. New technology in cosmetic industry. Prosp Indust Chem, 3(1):11-23, 2000.
  2. Lee, Y., Joo, Y., Kim, N. Polyphenol contents and physiological activity of the Lespedzea bicolor extracts. Kor J Food Preserv, 13(5):616-622, 2006.
  3. Kim, J. The prospects and current situation of cosmeceticals. J Skin Barrier Res, 6(1):45-52, 2004.
  4. Kim, C., Ahn, K., Park, K., Jeon, B., Lee, J., Park, J. Isolation of antioxidative compound from Scutellaria baicalensis G. Kor J Med Crop Sci, 14(4):212-216, 2006.
  5. Kim, K., Kim, S. Studies on the antimicrobial effect of herbal extracts and it's cosmetic application. J Kor Cosm, 13(1):221-227, 2007.
  6. Mok, J., Park, U., Kim, Y., Chang, D. Effects of solvents and extracting condition on the antimicrobial activity of Salviae miltiorrhizae Radix (Salvia miltiorrhiza) extract. J Kor Soc Food Nutr, 23(6):1001-1007, 1994.
  7. Kang, H., Chung, H., Byun, D., Chio, J. Further isolation of antioxidative (+)-1-hydroxypinoresinol-1-ο-$\beta$-D-glucoside from the rhizome of Salvia miltiorrhiza acts on peroxynitrite, total ROS and 1,1-diphenyl-2-picrylhydrazyl radical. Arch Pharm Res, 26(1):24-27, 2005. https://doi.org/10.1007/BF03179926
  8. Kim, O., Chung, S., Park, M., Rheu, H. and Yang, J. Anticancer activity of natural products including Salvia miltiorrhiza. J Appl Pharmacol, 7(1):29-33, 1999.
  9. Ahn, B., Kim, D., Chio, D. Antimultagenic effect of Tansen (Salvia siltiorrhiza Bunge). Kor J Appl Microbiol Biotechnol, 27(3):197-202, 1999.
  10. Oatsuka, K. Practical treatment of herbal medicine for various symptoms. Nanjantou, Tokyo, Japan.; p 17, 453, 653, 679, 1963.
  11. Lee, I., Kim, B., Kim, M. Biological Activity and Single Oral Dose Toxicity of Dansam-samultang. Lab Anim Res, 26(4):385-391, 2010. https://doi.org/10.5625/lar.2010.26.4.385
  12. Lee, I., Kim, B., Kim, M. Investigations of Samwhang -sasimtang extracts on biological activities in vitro and vivo. Lab Anim Res, 26(1):15-20, 2010. https://doi.org/10.5625/lar.2010.26.1.15
  13. Korea Food and Drug Administration of Good Laboratory Practice Regulations 2009-116.
  14. Korea Food and Drug Administration of Regulations for Cosmeceutical Evaluations 2009-166.
  15. Draize, J.H. Appraisal of the Safety of Chemical in Foods, Drugs and Cosmetics, The Staff of the Division of Pharmacology. Food and Drug Education and Welfare, Pub. 1959.
  16. Magnusson, B., Kligman, A.M. The identification of contact allergens by animal assay. The guinea pig maximization test. J Inv Derm, 52: 268-276, 1969. https://doi.org/10.1038/jid.1969.42