Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-inflammatory Effects of Saussurea Lappa Extracts in Murine Macrophages

설치류 대식세포에서 목향(木香) 추출물의 항염증 효과

  • Lee, Min-Suk (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Ryu, Do-Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kwon, Kang-Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
  • 이민석 (원광대학교 한의과대학 한방생리학교실) ;
  • 류도곤 (원광대학교 한의과대학 한방생리학교실) ;
  • 권강범 (원광대학교 한의과대학 한방생리학교실)
  • Received : 2011.03.04
  • Accepted : 2011.03.14
  • Published : 2011.04.25
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Abstract

In order to validate the use of Saussurea Lappa as an anti-inflammatory drug in the traditional Korean medicine, I have investigated the effects of water-soluble extract of Saussurea Lappa (ESL) on the production of pro-inflammatory tumor necrosis factor-alpha (TNF-${\alpha}$) in murine RAW 264.7 macrophages stimulated with the endotoxin lipopolysaccharide (LPS). The extract inhibited dose-dependently TNF-${\alpha}$ production without its cytotoxic effect on the macrophages, as measured by enzyme-linked immunosorbent assay, and significantly decreased mRNA levels of TNF-${\alpha}$, as determined using reverse transcription polymerase chain reaction. The extract also inhibited LPS-induced activation of nuclear factor-${\kappa}B$, thereby resulting in TNF-${\alpha}$ gene expression. These results suggest that ESL may have therapeutic potential in the control of inflammatory diseases mediated by activated macrophages.

Keywords

References

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