Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-allergic Activity of Dojuk-San Ethanol Extract

도적산(導赤散) 에탄올 추출물의 알레르기 억제효과

  • Sung, Sun-Heui (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Su-Kyoung (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Ok-Hwa (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Kwon, Dong-Yeul (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Chong, Myong-Soo (Department of Preventive Medicine, College of Oriental Medicine & Research Center of Traditional Korean Medicine, Wonkwang University) ;
  • Lee, Ki-Nam (Department of Preventive Medicine, College of Oriental Medicine & Research Center of Traditional Korean Medicine, Wonkwang University)
  • 성선희 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이수경 (원광대학교 한의과대학 한방재활의학 교실) ;
  • 강옥화 (원광대학교 약학대학 한약학과) ;
  • 권동렬 (원광대학교 약학대학 한약학과) ;
  • 정명수 (원광대학교 한의과대학 예방의학교실 & 전통의학연구소) ;
  • 이기남 (원광대학교 한의과대학 예방의학교실 & 전통의학연구소)
  • Received : 2011.03.25
  • Accepted : 2011.04.25
  • Published : 2011.06.25
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Abstract

Dojuk-San is known to be effective for treating a urinary diseases and stomatitis. However, its effects on the bone marrow-derived mast cell(BMMC) mediated allergy and inflammation mechanism remain unknown. In this study, the biological effects of Dojuk-San ethanol extract(DJS) were evaluated while focusing on its effects on the allergic mediator in phorbol 12-myristate 13-acetate(PMA) plus calcium ionophore A23187(A23187)-stimulated BMMCs. An investigation was also conducted to determine its effects on the production of several allergic mediators including interleukin-6(IL-6), prostaglandin D2($PGD_2$), leukotrieneC4(LTC4) and ${\beta}$-Hexosaminidase(${\beta}$-Hex). The results revealed that DJS inhibited the PMA plus A23187 induced production of IL-6, PGD2, LTC4 and ${\beta}$-Hex. Taken together, these findings indicate that DJS has the potential using in the treatment of allergy.

Keywords

References

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