Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Carthami Flos on Human Gastric Cancer Cells

홍화가 인체 위암세포에 미치는 효과

  • Kim, Jung-A (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University) ;
  • Han, Song-Ee (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University) ;
  • Song, Ho-Joon (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University) ;
  • Chae, Han (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University) ;
  • Kwon, Young-Kyu (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University) ;
  • Kim, Byung-Joo (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University)
  • 김정아 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 한송이 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 송호준 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 채한 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 권영규 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 김병주 (부산대학교 한의학전문대학원 양생기능의학부)
  • Received : 2011.03.21
  • Accepted : 2011.06.01
  • Published : 2011.06.25
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Abstract

The purpose of this study was to investigate the anti-cancer effects of Carthami Flos in some kinds of human gastric cancer cells. We used two kinds of human gastric cancer cell lines, such as AGS cells and MKN45 cells. We examined cell death by MTT assay and observed the morphological changes with Carthami Flos. Also, we showed that the combination of sub-optimal doses of Carthami Flos and cisplatin noticeably suppresses in AGS cells and doxorubicin in MKN45 cells. Furthermore, we studied the caspase 3 activity to identify the apoptosis. Therefore, our findings provide insight into unraveling the effects of Carthami Flos in human gastric cancer cells and developing therapeutic agents against gastric cancer.

Keywords

References

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