Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Hemispheric Asymmetry of Plasticity in the Human Motor Cortex Induced by Paired Associative Stimulation

말초신경-피질 연계자극에 의해 유도되는 운동피질 가소성의 비대칭성

  • Shin, Hae-Won (Department of Neurology, Yonsei University College of Medicine) ;
  • Sohn, Young-H. (Department of Neurology, Yonsei University College of Medicine)
  • 신혜원 (연세대학교 의과대학 신경과학교실) ;
  • 손영호 (연세대학교 의과대학 신경과학교실)
  • Received : 2010.11.11
  • Accepted : 2011.03.03
  • Published : 2011.06.30
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Abstract

Background: In the brain, the dominant primary motor cortex (M1) has a greater hand representation area, shows more profuse horizontal connections, and shows a greater reduction in intracortical inhibition after hand exercise than does the non-dominant M1, suggesting a hemispheric asymmetry in M1 plasticity. Methods: We performed a transcranial magnetic stimulation (TMS) study to investigate the hemispheric asymmetry of paired associative stimulation (PAS)-induced M1 plasticity in 9 right-handed volunteers. Motor evoked potentials (MEPs) were measured in the abductor pollicis brevis (APB) muscles of both hands, and MEP recruitment curves were measured at different stimulation intensities, before and after PAS. Results: MEP recruitment curves were significantly enhanced in the dominant, but not the non-dominant M1. Conclusions: These results demonstrate that the dominant M1 has greater PAS-induced plasticity than does the non-dominant M1. This provides neurophysiological evidence for the asymmetrical performance of motor tasks related to handedness.

Keywords

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