Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Green Tea Extract on Lipid Synthesis in Human Sebocyte Cell Line

녹차추출물이 인체 피지선세포주에서 지질 생성에 미치는 효과

  • Park, Si-Jun (Coreana Cosmetics Ltd, SongPa R&D Center) ;
  • Jeon, Byoung-Kook (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Dae-Sung (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ghang-Tai (Coreana Cosmetics Ltd, SongPa R&D Center) ;
  • Mun, Yeun-Ja (College of Oriental Medicine, Wonkwang University) ;
  • Lee, Kun-Kuk (Coreana Cosmetics Ltd, SongPa R&D Center) ;
  • Woo, Won-Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 박시준 (코리아나화장품 송파기술연구소) ;
  • 전병국 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 김대성 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이강태 (코리아나화장품 송파기술연구소) ;
  • 문연자 (원광대학교 한의과대학) ;
  • 이건국 (코리아나화장품 송파기술연구소) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Received : 2011.07.07
  • Accepted : 2011.07.26
  • Published : 2011.08.25
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Abstract

The aqueous Green tea comes to be used with the Oriental medicine plant, it has the numerous health benefits, including antioxidant, anti-inflammatory, and anti- carcinogenic properties. Epidermal progenitor cells give rise to multiple skin lineages: hair follicle, sebaceous gland and the overlying interfollicular epidermis. Sebocytes are the cells of the sebaceous gland, which synthesize and accumulate lipid dropolets. In order to determine the effect of Green tea on lipid production, several experiments were performed in SZ95 cells (sebocytes). We found that Green tea increased lipid droplets compared with control in a dose-dependent manner. Human sebaceous glands produce sebum, a lipid mixture of squalene, wax esters, triglycerides, cholesterol esters, and free fatty acids that is secreted onto the skin. Therefore, to investigate the effects of Green tea on intracellular lipid levels, we treated SZ95 cells with Green tea, and then examined cholesterol and triglyceride levels. After treatment of the cells with Green tea, the cholesterol and triglyceride levels of SZ95 cells were increased significantly in a dose-dependent manner.

Keywords

References

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