Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Domestic review of Korean medical treatment on Carbon Tetrachloride-induced Hepatotoxicity - Focusing on Treatment of Korean Herbal Medicine

본초학적 접근을 통해 본 국내에서 연구된 한약재의 사염화탄소로 유발된 간손상에 대한 간보호 효과

  • Kim, Na-Hyeon (Department of Oriental Physiology, College of Pharmacy, Kyung Hee University) ;
  • Kim, Soo-Il (Department of Oriental Physiology, College of Pharmacy, Kyung Hee University) ;
  • Shin, Min-Kyu (Department of Oriental Physiology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Jin-Ju (Department of Oriental Physiology, College of Pharmacy, Kyung Hee University)
  • 김나현 (경희대학교 약학대학 한방생리학교실) ;
  • 김수일 (경희대학교 약학대학 한방생리학교실) ;
  • 신민규 (경희대학교 한의과대학 한방생리학교실) ;
  • 김진주 (경희대학교 약학대학 한방생리학교실)
  • Received : 2011.03.29
  • Accepted : 2011.10.12
  • Published : 2011.10.25
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Abstract

The purpose of this study is to inspect trends of the paper of Korean medical treatment on Carbon Tetrachloride-induced Hepatotoxicity and try to establish the future direction for development of Korean herbal medicine. We reviewed 79 papers which had been published from 1981 to 2010 in journals published in Korea. According to these studies, Carbon Tetrachloride-induced hepato-celluar degeneration and necrosis induced to increase in serum aspartate amintransferase (AST), alanine aminotransferase (ALT), Alkaline phosphatase (ALP), ${\gamma}$-Glutamyl transferase (${\gamma}$-GTP), lactate dehydrogenase (LDH), bilirubin, blood urea nitrogen (BUN) and albumin levels. In biochemical analyses, antioxidant enzymes such as superoxide dismutase (SOD), Glutathione S-transferase (GST) and catalase in hepatic tissue were remarkably incresed by Carbon Tetrachloride treatment. We found that some of the herbal extracts have a protective effect against Carbon Tetrachloride-induced Hepatotoxicity. More studies of oriental medicinal herbs are required for developing a treatment of hepatotoxicity.

Keywords

References

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