Asian Pacific Journal of Cancer Prevention

  • 제13권7호
  • /
  • Pages.3047-3052
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Lack of Influence of MGMT Codon Leu84Phe and Codon Ileu143Val Polymorphisms on Esophageal Cancer Risk in the Kashmir Valley

  • Shah, Mohd A. (Department of Clinical Biochemistry, Sher-i-Kashmir Institute of Medical Sciences) ;
  • Shaffi, Sheikh M. (Department of Clinical Biochemistry, Sher-i-Kashmir Institute of Medical Sciences) ;
  • Lone, Ghulam Nabi (Department of Cardio-vascular and Thoracic Surgery, Sher-i-Kashmir Institute of Medical Sciences) ;
  • Jan, Syed Mudassar (Department of Clinical Biochemistry, Sher-i-Kashmir Institute of Medical Sciences)
  • 발행 : 2012.07.31
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초록

The enzyme encoded by the MGMT gene is involved in the repair of alkylated lesions formed in DNA by carcinogenic nitrosamines. Since dietary items consumed by the Kashmiri population contain high concentrations of these agents, it is biologically plausible that MGMT polymorphic variants may be associated with their risk of esophageal cancer. The present study was performed to assess whether non-synonymous SNPS at codon Leu84Phe and codon Ileu143Val of the MGMT gene, close to the active site of the protein, might be linked to predisposition of Kashmiris to esophageal cancer. Genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism on 92 cases and 77 healthy controls. Codon 84 and codon 143 SNPs of the MGMT gene were not associated with any increase in risk. While the frequency of the Phe allele at codon 84 in cases was (0.16), slightly higher than controls (0.12), the difference was not statistically significant. Similarly, the frequency of Valine allele in cases at codon 143 (0.08) and controls (0.09) was nearly equal. Moreover, no significant association of MGMT genotypes with the clinicopatholgic variables of esophageal cancer patients was observed. In conclusion, MGMT variants at codon 84 and codon143 may not be involved in the susceptibility of the Kashmiri population to esophageal cancer.

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참고문헌

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피인용 문헌

  1. The polymorphisms in the MGMT gene and the risk of cancer: a meta-analysis vol.34, pp.5, 2013, https://doi.org/10.1007/s13277-013-0893-x
  2. Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis vol.35, pp.3, 2014, https://doi.org/10.1007/s13277-013-1320-z
  3. Genetic unraveling of colorectal cancer vol.35, pp.6, 2014, https://doi.org/10.1007/s13277-014-1713-7
  4. Correlations of MGMT genetic polymorphisms with temozolomide resistance and prognosis of patients with malignant gliomas: a population-based study in China vol.24, pp.5, 2017, https://doi.org/10.1038/cgt.2017.7
  5. rs12917 polymorphism in cancer risk: an updated pooling analysis with 21010 cases and 34018 controls vol.38, pp.5, 2018, https://doi.org/10.1042/BSR20180942