Asian Pacific Journal of Cancer Prevention

  • 제13권7호
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  • Pages.3513-3517
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Influence of Alcohol Consumption on Oxidative Stress and Antioxidant Status in Cancer Patients - Case-control Study from Western Nepal

  • Nagamma, T. (Department of biochemistry, Melaka Manipal Medical College) ;
  • Bhutia, Rinchen Doma (Department of Biochemistry, Sikkim Manipal Institute of Medical Sciences) ;
  • Pokharel, Daya Ram (Department of Physiology, Narayana Medical College) ;
  • Yadav, Saraswati (Department of biochemistry, Manipal College of Medical Sciences) ;
  • Baxi, J. (Department of Surgery, Manipal College of Medical Sciences)
  • 발행 : 2012.07.31
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초록

Aim: The present study assess the effect of consumption of alcohol on oxidative stress and antioxidant status in patients suffering from different types of cancer. Methods: This hospital based case control study conducted in the Western part of Nepal covered a total of 93 cancer patients with or without alcohol intake and smoking habits, along with 94 age, sex and habit-matched individuals serving as controls. Plasma thiobarbituric acid reacting substances (TBARS), total antioxidant activity (TAA), vitamin C, ${\alpha}$-tocopherol and erythrocyte reduced glutathione (GSH) were estimated and compared. Results: The TBARS level was found to be significantly higher ($p{\leq}0.001$) in all types of cancer patients when compared to controls, being aggravated in alcoholics with a smoking habit. No statistical significance ($p{\geq}0.05$) was observed in the level of vitamin C and ${\alpha}$-tocopherol. GSH and TAA level were significantly decreased ($p{\leq}0.001$) in all the groups except those who consumed both branded as well as homemade alcohol and non-alcoholics without smoking habit. Conclusion: Alcohol, irrespective of its commercial brand, increases oxidative stress in all types of cancer patients. This is even higher when alcohol intake is combined with a smoking habit. Decreased TAA and GSH are major risk factors for cancer development.

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