Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Usefulness of the PRESS Technique using 3.0T Magnetic Resonance Spectroscopy for Evaluation of Non-Alcoholic Fatty Liver Disease Patients

비알콜성 지방간환자 평가를 위한 3.0T 고자기장 자기공명분광법을 이용한 PRESS 기법의 유용성

  • Goo, Eun-Hoe (Department of Radiological Science, Cheongju University)
  • 구은회 (청주대학교 방사선학과)
  • Received : 2012.10.25
  • Accepted : 2012.12.06
  • Published : 2012.12.31
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Abstract

This study was to evaluate the clinical usefulness of the PRESS technique based on the correlation between PRESS technique and biopsy results by applying 3.0T high magnetic field MRS technique for evaluation of non-alcoholic fatty liver disease patients. This experiment were carried out using a 3.0T magnetic resonance imaging equipment. The part data of each spectrum is taken by peak area integration. The part data of resonance peak was used to calculate relative ratio. MR spectral peak in patients with non-alcoholic fatty liver disease is from 0.9 to 1.6 ppm. According to MRS method study result, Patients with NAFLD were obtained with 94% sensitivity and 80% specificity(p=0.000). When compared to normal based on MRS and Biopsy results was valid correlation(r=0.79, p=0.04). Results for NAFLD(r=0.89, p=0.002) also showed a correlation. Therefore, PRESS technique to evaluate patients with non-alcoholic fatty liver disease, the distribution difference between normal liver and fatty liver part is significantly distinguished. Biopsy and MRS fatty liver peak ratio(%) proves high lipid over grade(r = 0.7).

3.0T 고자기장 자기공명분광법에서 비알콜성 지방간 환자 평가를 위해 PRESS 기법과 Biopsy결과의 상관관계를 토대로 PRESS 기법의 임상적 유용성을 알아보았다. 본 실험은 3.0T 고자지장 자기공명영상 장비를 이용하여 실험을 하였고 분광스펙트럼을 적분(peak area integration) 방법으로 면적을 구하여 간지방량에 상대비율에 따른 공명피크의 면적을 이용하여 계산하였다. 비알콜성 지방간환자에서 MR 스펙트럼 피크가 모두 0.9 - 1.6 ppm에서 나타났으며 비알콜성 환자에 대하여 MRS와 Biopsy 결과 민감도 94%와 특이도 80%로 높은 값을 얻었다(p=0.000). 정상(r=0.79, p=0.04) 및 비알콜성 지방간질환 대한 결과( r=0.89, p=0.002) 역시 높은 상관관계를 보여주었다. 따라서 3.0T 고자장 MRS을 적용했을 때 PRESS 기법은 비알콜성 지방간 환자를 평가하는데 있어서 정상부분과 지방간부분의 구별을 가능하게 하였으며 생검검사와 MRS의 상관관계 분석에서 간지방량 비율(%)은 r값이 0.7 이상의 높은 Lipid를 제공하여 PRESS 기법의 임상적 유용성을 권고 할 만하였다.

Keywords

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