Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Monosomal Karyotypes among 1147 Chinese Patients with Acute Myeloid Leukemia: Prevalence, Features and Prognostic Impact

  • Yang, Xiao-Fei (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Sun, Ai-Ning (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Yin, Jia (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Cai, Cheng-Sen (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Tian, Xiao-Peng (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Qian, Jun (Department of Hematology, Affiliated People's Hospital of Jiangsu University) ;
  • Chen, Su-Ning (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Wu, De-Pei (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health)
  • Published : 2012.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

A monosomal karyotype (MK), defined as ${\geq}2$ autosomal monosomies or a single monosomy in the presence of additional structural abnormalities, was recently identified as an independent prognostic factor conveying an extremely poor prognosis in patients with acute myeloid leukemia (AML). In the present study, after excluding patients with t(15;17), t(8;21), inv(16) and normal karyotypes, 324 AML patients with cytogenetic abnormalities were the main subject of analysis. The incidences of MK were 13% in patients aged 15 to 60 years and 18% in those between 15 and 88 years old. MK was much more prevalent among elderly patients (p < 0.001) and was significantly associated with the presence of -7, -5, del(5q), abn12p, abn17p, -18 or 18q-, -20 or 20q- and CK (for all p < 0.001 except for abn12p p=0.009), and +8 or +8q was less frequent in MK+ AML(p=0.007). No correlation was noted between monosomal karyotype and FAB subtype (p > 0.05); MK remained significantly associated with worse overall survival among patients with complex karyotype (p=0.032); A single autosomal monosomy contributed an additional negative effect in OS of patients with structural cytogenetic abnormalities (P=0.008). This report presents the prevalence, feature and prognostic impact of MK among a large series of Chinese AML patients from a single center for the first time.

Keywords

References

  1. Ahn HK, Jang JH, Kim K, et al (2012). Monosomal karyotype in acute myeloid leukemia predicts adverse treatment outcome and associates with high functional multidrug resistance activity. Am J Hematol, 87, 37-41. https://doi.org/10.1002/ajh.22193
  2. Breems DA, Van Putten WLJ, De Greef GE, et al (2008). Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol, 26, 4791-7. https://doi.org/10.1200/JCO.2008.16.0259
  3. Byrd JC, Mrozek K, Dodge RK, et al (2002). Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood, 100, 4325-36. https://doi.org/10.1182/blood-2002-03-0772
  4. Chen B, Zhao WL, Jin J, et al (2005). Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries. Leukemia, 19, 767-75. https://doi.org/10.1038/sj.leu.2403688
  5. Cheng Y, Wang Y, Wang H, et al (2009). Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China. Leukemia, 23, 1801-6. https://doi.org/10.1038/leu.2009.107
  6. Cornelissen JJ, Breems D, van Putten WL, et al (2012). Comparative analysis of the value of allogeneic hematopoietic stem-cell transplantation in acute myeloid leukemia with monosomal karyotype versus other cytogenetic risk categories. J Clin Oncol, 30, 2140-6. https://doi.org/10.1200/JCO.2011.39.6499
  7. Fang M, Storer B, Estey E, et al (2011). Outcome of patients with acute myeloid leukemia with monosomal karyotype who undergo hematopoietic cell transplantation. Blood, 118, 1490-4. https://doi.org/10.1182/blood-2011-02-339721
  8. Grimwade D, Hills RK, Moorman AV, et al (2010). Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood, 116, 354-65. https://doi.org/10.1182/blood-2009-11-254441
  9. Haferlach C, Alpermann T, Schnittger S, et al (2012). Prognostic value of "monosomal karyotype" in comparison to "complex aberrant karyotype" in acute myeloid leukemia: study on 824 cases with aberrant karyotype. Blood, 119, 2122-5. https://doi.org/10.1182/blood-2011-10-385781
  10. Johansson B, Mertens F, Mitelman F (1991). Geographic heterogeneity of neoplasia-associated chromosome aberrations. Genes Chromosomes Cancer, 3, 1-7. https://doi.org/10.1002/gcc.2870030102
  11. Kayser S, Zucknick M, Dohner K, et al (2012). Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies. Blood, 119, 551-8. https://doi.org/10.1182/blood-2011-07-367508
  12. Lowenberg B, Pabst T, Vellenga E, et al (2011). Cytarabine dose for acute myeloid leukemia. N Engl J Med, 364, 1027-36. https://doi.org/10.1056/NEJMoa1010222
  13. Medelros BC, Othus M, Appelbaum FR (2011). Cytarabine dose for acute myeloid leukemia. N Engl J Med, 364, 2167-8; author reply 2168-9.
  14. Medeiros BC, Othus M, Fang M, et al (2010). Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience. Blood, 116, 2224-8. https://doi.org/10.1182/blood-2010-02-270330
  15. Mrozek K, Heerema NA, Bloomfeld CD (2004). Cytogenetics in acute leukemia. Blood Rev, 18, 115-36. https://doi.org/10.1016/S0268-960X(03)00040-7
  16. Nakase K, Bradstock K, Sartor M, et al (2000). Geographic heterogeneity of cellular characteristics of acute myeloid leukemia: a comparative study of Australian and Japanese adult cases. Leukemia, 14, 163-8. https://doi.org/10.1038/sj.leu.2401638
  17. Oran B, Dolan M, Cao Q, et al (2011). Monosomal Karyotype Provides Better Prognostic Prediction after Allogeneic Stem Cell Transplantation in AML Patients. Biol Blood Marrow Transplant, 17, 356-64. https://doi.org/10.1016/j.bbmt.2010.05.012
  18. Patnaik MM, Hanson CA, Hodnefield JM, et al (2011). Monosomal karyotype in myelodysplastic syndromes, with or without monosomy 7 or 5 , is prognostically worse than another wise complex karyotype. Leukemia, 25, 266-70. https://doi.org/10.1038/leu.2010.258
  19. Perrot A, Luquet I, Pigneux A, et al (2011). Dismal prognostic value of monosomal karyotype in elderly patients with acute myeloid leukemia: a GOELAMS study of 186 patients with unfavorable cytogenetic abnormalities. Blood, 118, 679-85. https://doi.org/10.1182/blood-2010-09-307264
  20. Rucker FG, Schlenk RF, Bullinger L, et al (2012). TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood, 119, 2114-21. https://doi.org/10.1182/blood-2011-08-375758
  21. Sanderson RN, Johnson PRE, Moorman AV, et al (2006). Population-based demographic study of karyotypes in 1709 patients with adult acute myeloid leukemia. Leukemia, 20, 444-50. https://doi.org/10.1038/sj.leu.2404055
  22. Slovak ML, Kopecky KJ, Cassileth PA, et al (2000). Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood, 96, 4075-83.
  23. Vaidya R, Caramazza D, Begna KH, et al (2011). Monosomal karyotype in primary myelofibrosis is detrimental to both overall and leukemia-free survival. Blood, 117, 5612-15. https://doi.org/10.1182/blood-2010-11-320002
  24. Yanada M, Kurosawa S, Yamaguchi T, et al (2012). Prognosis of acute myeloid leukemia harboring monosomal karyotype in patients treated with or without allogeneic hematopoietic cell transplantation after achieving complete remission. Haematologica, 97, 915-8. https://doi.org/10.3324/haematol.2011.058289

Cited by

  1. Decitabine in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes, Which Combined with Complex Karyotype Respectively vol.16, pp.15, 2015, https://doi.org/10.7314/APJCP.2015.16.15.6627
  2. Demographic and Clinical Characteristics of Adult Acute Myeloid Leukemia - Tertiary Care Experience vol.17, pp.1, 2016, https://doi.org/10.7314/APJCP.2016.17.1.357
  3. Acute Myeloid Leukemia: Clinical Spectrum of 125 Patients vol.17, pp.1, 2016, https://doi.org/10.7314/APJCP.2016.17.1.369
  4. Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report pp.0, 2018, https://doi.org/10.1590/1516-3180.2016.0252150217
  5. Complex Karyotype in Hematological Diseases: A 6-Year Single Centre Study from Pakistan vol.2018, pp.1687-8469, 2018, https://doi.org/10.1155/2018/2019239