Asian Pacific Journal of Cancer Prevention

  • 제13권11호
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  • Pages.5421-5426
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Monosomal Karyotypes among 1147 Chinese Patients with Acute Myeloid Leukemia: Prevalence, Features and Prognostic Impact

  • Yang, Xiao-Fei (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Sun, Ai-Ning (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Yin, Jia (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Cai, Cheng-Sen (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Tian, Xiao-Peng (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Qian, Jun (Department of Hematology, Affiliated People's Hospital of Jiangsu University) ;
  • Chen, Su-Ning (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health) ;
  • Wu, De-Pei (The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health)
  • 발행 : 2012.11.30
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초록

A monosomal karyotype (MK), defined as ${\geq}2$ autosomal monosomies or a single monosomy in the presence of additional structural abnormalities, was recently identified as an independent prognostic factor conveying an extremely poor prognosis in patients with acute myeloid leukemia (AML). In the present study, after excluding patients with t(15;17), t(8;21), inv(16) and normal karyotypes, 324 AML patients with cytogenetic abnormalities were the main subject of analysis. The incidences of MK were 13% in patients aged 15 to 60 years and 18% in those between 15 and 88 years old. MK was much more prevalent among elderly patients (p < 0.001) and was significantly associated with the presence of -7, -5, del(5q), abn12p, abn17p, -18 or 18q-, -20 or 20q- and CK (for all p < 0.001 except for abn12p p=0.009), and +8 or +8q was less frequent in MK+ AML(p=0.007). No correlation was noted between monosomal karyotype and FAB subtype (p > 0.05); MK remained significantly associated with worse overall survival among patients with complex karyotype (p=0.032); A single autosomal monosomy contributed an additional negative effect in OS of patients with structural cytogenetic abnormalities (P=0.008). This report presents the prevalence, feature and prognostic impact of MK among a large series of Chinese AML patients from a single center for the first time.

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참고문헌

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피인용 문헌

  1. Decitabine in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes, Which Combined with Complex Karyotype Respectively vol.16, pp.15, 2015, https://doi.org/10.7314/APJCP.2015.16.15.6627
  2. Demographic and Clinical Characteristics of Adult Acute Myeloid Leukemia - Tertiary Care Experience vol.17, pp.1, 2016, https://doi.org/10.7314/APJCP.2016.17.1.357
  3. Acute Myeloid Leukemia: Clinical Spectrum of 125 Patients vol.17, pp.1, 2016, https://doi.org/10.7314/APJCP.2016.17.1.369
  4. Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report pp.0, 2018, https://doi.org/10.1590/1516-3180.2016.0252150217
  5. Complex Karyotype in Hematological Diseases: A 6-Year Single Centre Study from Pakistan vol.2018, pp.1687-8469, 2018, https://doi.org/10.1155/2018/2019239