Asian Pacific Journal of Cancer Prevention

  • 제13권11호
  • /
  • Pages.5517-5523
  • /
  • 2012
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Diagnostic Accuracy of Ultrasonograph Guided Fine-needle Aspiration Cytologic in Staging of Axillary Lymph Node Metastasis in Breast Cancer Patients: a Meta-analysis

  • 발행 : 2012.11.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: To evaluate the diagnostic accuracy of ultrasonograph and fine-needle aspiration cytologic examination (USG-FNAC) in the staging of axillary lymph node metastasis in breast cancer patients.Methods: We conducted an electronic search of the literature addressing the performance of USG-FNAC in diagnosis of axillary lymph node metastasis in databases such as Pubmed, Medline, Embase, Ovid and Cochrane library. We introduced a series of diagnostic test indices to evaluate the performance of USG-FNAC by the random effect model (REM), including sensitivity, specificity, likelihood ratios, and diagnostic odds ratios and area under the curve (AUC). Results: A total of 20 studies including 1371 cases and 1289 controls were identified. The pooled sensitivity was determined to be 0.66 (95% CI 0.64-0.69), specificity 0.98 (95% CI 0.98-0.99), positive likelihood ratio 22.7 (95% CI 15.0-34.49), negative likelihood ratio 0.32 (95% CI 0.25-0.41), diagnostic OR 84.2 (95% CI 53.3-133.0). Due to the marginal threshold effect found in some indices of diagnostic validity, we used a summary SROC curve to aggregate data, and obtained a symmetrical curve with an AUC of 0.942. Conclusion: The results of this meta-analysis indicated that the USG-FNAC techniques have acceptable diagnostic validity indices and can be used for early staging of axillary lymph node in breast cancer patients.

키워드

참고문헌

  1. Adler LP, Crowe JP, Al-Kaisi NK, et al (1993). Evaluation of breast masses and axillary lymph nodes with [F-18] 2-deoxy-2-fluoro- D-glucose PET. Radiology, 187, 743-50 https://doi.org/10.1148/radiology.187.3.8497624
  2. Alkuwari E, Auger M (2008). Accuracy of fine-needle aspiration cytology of axillary lymph nodes in breast cancer patients: a study of 115 cases with cytologic-histologic correlation. Cancer, 114, 89-93. https://doi.org/10.1002/cncr.23344
  3. Altomare V, Guerriero G, Carino R, et al (2007). Axillary lymph node echo-guided fine-needle aspiration cytology enables breast cancer patients to avoid a sentinel lymph node biopsy. Preliminary experience and a review of the literature. Surg Today, 37, 735-9. https://doi.org/10.1007/s00595-006-3366-7
  4. Baruah BP, Goyal A, Young P, et al (2010). Axillary node staging by ultrasonography and fine-needle aspiration cytology in patients with breast cancer. Br J Surg, 97, 680-3. https://doi.org/10.1002/bjs.6964
  5. Bedrosian I, Bedi D, Kuerer HM, et al (2003). Impact of clinicopathological factors on sensitivity of axillary ultrasonography in the detection of axillary nodal metastases in patients with breast cancer. Ann Surg Oncol, 10, 1025-30. https://doi.org/10.1245/ASO.2003.12.017
  6. Begg CB (1987). Biases in the assessment of diagnostic tests. Stat Med, 6, 411-23. https://doi.org/10.1002/sim.4780060402
  7. Bonnema J, van Geel AN, van Ooijen B, et al (1997) .Ultrasoundguided aspiration biopsy for detection of nonpalpable axillary node metastases in breast cancer patients: new diagnostic method. World J Surg, 21, 270-4. https://doi.org/10.1007/s002689900227
  8. Carroll PA, O'Mahony D, McDermott R, et al (2011). Perioperative diagnosis of the positive axilla in breast cancer: a safe, time efficient algorithm. Eur J Surg Oncol, 37, 205-10. https://doi.org/10.1016/j.ejso.2011.01.002
  9. Ciatto S, Brancato B, Risso G, et al (2007). Accuracy of fine needle aspiration cytology (FNAC) of axillary lymph nodes as a triage test in breast cancer staging. Breast Cancer Res Treat, 103, 85-91. https://doi.org/10.1007/s10549-006-9355-0
  10. De Freitas R Jr, Costa MV, Schneider SV, et al (1991). Accuracy of ultrasound and clinical examination in the diagnosis of axillary lymph node metastasis in breast cancer. Eur J Surg Oncol, 17, 240-4.
  11. de Kanter AY, van Eijck CH, van Geel AN, et al (1999). Multicentre study of ultrasonographically guided axillary node biopsy in patients with breast cancer. Br J Surg, 86, 1459-62 https://doi.org/10.1046/j.1365-2168.1999.01243.x
  12. DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  13. Deurloo EE, Tanis PJ, Gilhuijs KG, et al (2003). Reduction in the number of sentinel lymph node procedures by preoperative ultrasonography of the axilla in breast cancer. Eur J Cancer, 39, 1068-73. https://doi.org/10.1016/S0959-8049(02)00748-7
  14. Devaraj S, Iqbal M, Donnelly J, et al (2011).Axillary ultrasound in invasive breast cancer: experience of our surgeons. Breast J, 17,191-5. https://doi.org/10.1111/j.1524-4741.2010.01043.x
  15. Duchesne N, Jaffey J, Florack P, et al (2005). Redefining ultrasound appearance criteria of positive axillary lymph nodes. Can Assoc Radiol J, 56, 289-96.
  16. Fisher B, Bauer M, Wickerham D, et al (1983). Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer: an NSABP update. Cancer, 52, 1551-7 https://doi.org/10.1002/1097-0142(19831101)52:9<1551::AID-CNCR2820520902>3.0.CO;2-3
  17. Fisher ER, Anderson S, Redmond C, et al (1993). Pathologic findings from the national surgical adjuvant breast project protocol B-06. 10- year pathologic and clinical prognostic discriminants. Cancer, 71, 2507-24. https://doi.org/10.1002/1097-0142(19930415)71:8<2507::AID-CNCR2820710813>3.0.CO;2-0
  18. Glas AS, Lijmer JG, Prins MH, et al (2003). The diagnostic odds ratio: a single indicator of test performance. J Clin Epidemiol, 56, 1129-35. https://doi.org/10.1016/S0895-4356(03)00177-X
  19. Hayes BD, Feeley L, Quinn CM, et al (2011). Axillary fine needle aspiration cytology for pre-operative staging of patients with screen-detected invasive breast carcinoma. J Clin Pathol, 64, 338-42. https://doi.org/10.1136/jcp.2010.084772
  20. Herrada J, Iyer RB, Atkinson EN, et al (1997). Relative value of physical examination, mammography, and breast sonography in evaluating the size of the primary tumor and regional lymph node metastasiss in women receiving neoadjuvant chemotherapy for locally advanced breast carcinoma. Clin Cancer Res, 3, 1565-9.
  21. Higgins J, Thompson S, Deeks J, et al (2003) .Measuring inconsistency in meta-analyses. Br Med J, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
  22. Irwig L, Macaskill P, Glasziou P, et al (1995). Meta-analytic methods for diagnostic test accuracy. J Clin Epidemiol, 48, 119-30. https://doi.org/10.1016/0895-4356(94)00099-C
  23. Jung J, Park H, Park J, et al (2010). Accuracy of preoperative ultrasound and ultrasound-guided fine needle aspiration cytology for axillary staging in breast cancer. ANZ J Surg, 80, 271-5. https://doi.org/10.1111/j.1445-2197.2009.05090.x
  24. Kissin MW, Querci della Rovere G, Easton D, et al (1986). Risk of lymphoedema following the treatment of breast cancer. Br J Surg, 73, 580-4. https://doi.org/10.1002/bjs.1800730723
  25. Krishnamurthy S, Sneige N, Bedi DG, et al (2002). Role of ultrasound-guided fine-needle aspiration of indeterminate and suspicious axillary lymph nodes in the initial staging of breast carcinoma. Cancer, 95, 982-8. https://doi.org/10.1002/cncr.10786
  26. Krishnamurthy S, Sneige N, Bedi DG, et al (2002). Role of ultrasound-guided fine-needle aspiration of indeterminate and suspicious axillary lymph nodes in the initial staging of breast carcinoma. Cancer, 95, 982-8. https://doi.org/10.1002/cncr.10786
  27. Kuenen-Boumeester V, Menke-Pluymers M, de Kanter AY, et al (2003). Ultrasound-guided fine needle aspiration cytology of axillary lymph nodes in breast cancer patients. A preoperative staging procedure. Eur J Cancer, 39, 170-4. https://doi.org/10.1016/S0959-8049(02)00501-4
  28. Lotze MT, Duncan MA (1981). Gerber LH, Woltering EA, Rosenberg SA. Early versus delayed shoulder motion following axillary dissection: a randomized prospective study. Ann Surg, 193, 288-95. https://doi.org/10.1097/00000658-198103000-00007
  29. Luparia A, Campanino P, Cotti R, et al (2010). Role of axillary ultrasound in the preoperative diagnosis of lymph node metastases in patients affected by breast carcinoma. Radiol Med, 115, 225-37. https://doi.org/10.1007/s11547-009-0465-8
  30. Moses LE, Shapiro D, Littenberg B (1993). Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations. Stat Med, 12, 1293-316. https://doi.org/10.1002/sim.4780121403
  31. Pamilo M, Soiva M, Lavast EM (1989). Real time ultrasound, axillary mammography and clinical examination in the detection of axillary lymph node metastasiss in breast cancer patients. J Ultrasound Med, 8, 115-20. https://doi.org/10.7863/jum.1989.8.3.115
  32. Parkin DM, Bray F, Ferlay J, et al (2005). Global cancer statistics, 2002. Ca Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  33. Podkrajsek M, Music MM, Kadivec M, et al (2005). Role of ultrasound in the preoperative staging of patients with breast cancer. Eur Radiol, 15, 1044-50. https://doi.org/10.1007/s00330-004-2545-4
  34. Popli MB, Sahoo M, Mehrotra N, et al (2006). Preoperative ultrasound-guided fine-needle aspiration cytology for axillary staging in breast carcinoma. Australas Radiol, 50, 122-6. https://doi.org/10.1111/j.1440-1673.2006.01545.x
  35. Sacre RA (1986). Clinical evaluation of axillary lymph nodes compared to surgical and pathological findings. Eur J Surg Oncol, 12, 169-73.
  36. Samphao S, Eremin JM, El-Sheemy M, et al (2008). Management of the axilla in women with breast cancer: current clinical practice and a new selective targeted approach. Ann Surg Oncol, 15, 1282-96. https://doi.org/10.1245/s10434-008-9863-8
  37. Sapino A, Cassoni P, Zanon E, et al (2003). Ultrasonographicallyguided fine-needle aspiration of axillary lymph nodes: role in breast cancer management. Br J Cancer, 88, 702-6. https://doi.org/10.1038/sj.bjc.6600744
  38. Schiettecatte A, Bourgain C, Breucq C, et al (2011). Initial axillary staging of breast cancer using ultrasound-guided fine needle aspiration: a liquid-based cytology study. Cytopathology, 22, 30-5. https://doi.org/10.1111/j.1365-2303.2010.00738.x
  39. Schwartz GF, Giuliano AE, Veronesi U (2002). Proceedings of the consensus conference on the role of sentinel lymph node biopsy in carcinoma of the breast, April 19-22, 2001, Philadelphia, Pennsylvania. Cancer, 94, 2542-51. https://doi.org/10.1002/cncr.10539
  40. Shaw JH, Rumball EM (1990). Complications and local recurrence following lymphadenectomy. Br J Surg, 77, 760-4. https://doi.org/10.1002/bjs.1800770715
  41. Song F, Khan KS, Dinnes J, et al (2002). Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy. Int J Epidemiol, 31, 88-95. https://doi.org/10.1093/ije/31.1.88
  42. Tahir M, Osman KA, Shabbir J, et al (2008). Preoperative axillary staging in breast cancer-saving time and resources. Breast J, 14, 369-71. https://doi.org/10.1111/j.1524-4741.2008.00600.x
  43. van Rijk MC, Deurloo EE, Nieweg OE, et al (2006). Ultrasonography and fine-needle aspiration cytology can spare breast cancer patients unnecessary sentinel lymph node biopsy. Ann Surg Oncol, 13, 31-5. https://doi.org/10.1245/ASO.2005.01.024
  44. vens D, Hoe AL, Podd TJ, et al (1992). Assessment of morbidity from complete axillary dissection. Br J Cancer, 66, 136-8. https://doi.org/10.1038/bjc.1992.230
  45. Whiting P, Rutjes AW, Reitsma JB, et al (2003). The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 3, 25.
  46. Whiting P, Weswood ME, Rutjes AW, et al (2006). Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies (update). BMC Med Res Methodol, 6, 9. https://doi.org/10.1186/1471-2288-6-9
  47. Zamora J, Abraira V, Muriel A, et al (2006). Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol, 6, 31. https://doi.org/10.1186/1471-2288-6-31

피인용 문헌

  1. Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta-analysis vol.1, pp.4, 2013, https://doi.org/10.3892/br.2013.114
  2. Stereotactic Vacuum-Assisted Core Biopsy Results for Non-Palpable Breast Lesions vol.15, pp.13, 2014, https://doi.org/10.7314/APJCP.2014.15.13.5171
  3. Cytomorphologic Patterns of Breast Lesions in Sudanese Patients: Lessons Learned from Fine Needle Aspiration Cytology vol.15, pp.8, 2014, https://doi.org/10.7314/APJCP.2014.15.8.3411
  4. Fine needle aspiration cytology of lymph nodes in breast cancer follow-up is a feasible alternative to watchful waiting and to histology vol.15, pp.1, 2015, https://doi.org/10.1186/s12905-015-0269-z