Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Polymorphisms of XRCC1 and ADPRT Genes and Risk of Noncardia Gastric Cancer in a Chinese Population: a Case-control Study

  • Pan, Xiong-Fei (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Xie, Yao (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Loh, Marie (Cancer Science Institute of Singapore) ;
  • Yang, Shu-Juan (Department of Child and Adolescent Health, West China School of Public Health, Sichuan University) ;
  • Wen, Yuan-Yuan (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Tian, Zhi (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Huang, He (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Lan, Hui (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Chen, Feng (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Soong, Richie (Cancer Science Institute of Singapore) ;
  • Yang, Chun-Xia (Department of Epidemiology, West China School of Public Health, Sichuan University)
  • Published : 2012.11.30
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Abstract

Objective: Gastric cancer (GC) is one of the most common malignancies and its mortality ranks third among all cancers in China. We previously noted that XRCC1 Arg194Trp was associated with GC risk in Western China in a study on XRCC1 Arg194Trp and ADPRT Val762Ala. We aimed to further explore the association of these polymorphisms with risk of the noncardia subtype. Methods: We enrolled 176 noncardia GC patients and 308 controls from four hospitals and a community between October 2010 and August 2011. Genotyping was performed in a 384-well plate format on the Sequenom MassARRAY platform. A self-designed questionnaire was utilized to collect epidemiological data from the subjects regarding demographic factors and potential risk factors. Results: Subjects were aged $56.8{\pm}11.8$ (mean ${\pm}$ standard deviation) and $57.6{\pm}11.1$ years in the case and control groups, respectively. Individuals carrying the XRCC1 Trp/Trp or Arg/Trp variant genotype were at significantly increased risk of noncardia GC (adjusted OR, 1.48; 95% CI, 1.00-2.17), after adjustment for family history of cancer, drinking, and smoking. The increased risk of XRCC1 Arg194Trp variant genotype was more pronounced among subjects below 60 years old (adjusted OR, 1.78; 95% CI, 1.07-2.96), compared to older individuals. ADPRT Val762Ala variants (Ala/Ala or Val/Ala) were not associated with noncardia GC (adjusted OR, 1.03; 95% CI, 0.69-1.54). Conclusions: Our study suggests that XRCC1 Arg194Trp is a genetic susceptibility factor for developing noncardia GC in Han Chinese in Western China. In particular, individuals with the XRCC1 Arg194Trp variant genotype are at increased risk for GC below 60 years old.

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