Asian Pacific Journal of Cancer Prevention

  • 제13권11호
  • /
  • Pages.5729-5733
  • /
  • 2012
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Early Detection and Gemcitabine/Cisplatin Combination Positively Effect Survival in Sarcomatoid Carcinoma of the Urinary Bladder

  • Baseskioglu, Barbaros (Department of Urology, ESOGU Medical Faculty) ;
  • Duman, Berna Bozkurt (Department of Medical Oncology, Cukurova University Medical Faculty) ;
  • Kara, I. Oguz (Department of Medical Oncology, Cukurova University Medical Faculty) ;
  • Can, Cavit (Department of Urology, ESOGU Medical Faculty) ;
  • Yildirim, Mustafa (Antalya Education and Research Hospital) ;
  • Acikalin, Mustafa (Department of Pathology, ESOGU Medical Faculty)
  • 발행 : 2012.11.30
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초록

Background and Objectives: This study aimed to present the clinicopathological characteristics and treatment of patients with bladder carcinoma with sarcomatoid differentiation at our institution. Methods: Between 1995-2009, 950 patients were followed-up for bladder carcinoma. Among them, 14 patients with sarcomatoid carcinoma were retrospectively reviewed, and their clinical, pathological features and treatment were recorded. Results: Median age of the patients was 65 years (range: 41-86 years), 12 (86%) being male and 2 (14%) female. All the patients presented with hematuria and 11 (88%) had a history of smoking. The tumor growth pattern was solid in 10 patients, papillary in 2, and mixed in 2. In all, 5 of the patients had urothelial carcinoma with sarcomatoid differentiation and 9 were diagnosed with sarcomatoid carcinoma. Five patients underwent radical cystectomy with ileal conduit surgery, 2 patients refused cystectomy, and 8 patients underwent re-TUR. Following diagnosis, 12 of the patients died in mean 10.7 months (range: 1-48 months). Conclusion: Urothelial carcinomas with sarcomatoid features are aggressive and are usually at advanced stage at the time of diagnosis. The outcomes of multimodal treatment are not satisfactory. Significant findings of the present study are that early diagnosis positively affect survival and that gemcitabine and cisplatin in combination can positively affect survival.

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참고문헌

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피인용 문헌

  1. A Case of Early Stage Bladder Carcinosarcoma in Late Recurrence of Urothelial Carcinoma after Transurethral Resection vol.2018, pp.2090-6978, 2018, https://doi.org/10.1155/2018/1405108