DOI QR코드

DOI QR Code

Vascular Invasion as an Independent Prognostic Factor in Lymph Node Negative Invasive Breast Cancer

  • Rezaianzadeh, Abbas (Research Center for Health Sciences, Department of Epidemiology, School of Health and Nutrition) ;
  • Talei, Abdolrasoul (Department of Surgical Oncology, Shiraz University of Medical Sciences) ;
  • Rajaeefard, Abdereza (Research Center for Health Sciences, Department of Epidemiology, School of Health and Nutrition) ;
  • Hasanzadeh, Jafar (Research Center for Health Sciences, Department of Epidemiology, School of Health and Nutrition) ;
  • Tabatabai, Hamidreza (Research Center for Health Sciences, Department of Epidemiology, School of Health and Nutrition) ;
  • Tahmasebi, Sedigheh (Department of Surgical Oncology, Shiraz University of Medical Sciences) ;
  • Mousavizadeh, Ali (Research Center for Health Sciences, Department of Epidemiology, School of Health and Nutrition)
  • 발행 : 2012.11.30

초록

Introduction: Identification of simple and measurable prognostic factors is an important issue in treatment evaluation of breast cancer. The present study was conducted to evaluate the prognostic role of vascular invasion in lymph node negative breast cancer patients. Methods: in a retrospective design, we analyzed the recorded profiles of the 1,640 patients treated in the breast cancer department of Motahari clinic affiliated to Shiraz University of Medical Sciences, Shiraz, Iran, from January 1999 to December 2012. Overall and adjusted survivals were evaluated by the Cox proportional hazard model. All the hypotheses were considered two-sided and a p-value of 0.05 or less was considered as statistically significant. Results: Mean age in lymph node negative and positive patients was 50.0 and 49.8 respectively. In lymph node negative patients, the number of nodes, tumor size, lymphatic invasion, vascular invasion, progesterone receptor, and nuclear grade were significant predictors. In lymph node and lymphatic negative patients, vascular invasion also played a significant prognostic role in the survival which was not evident in lymph node negative patients with lymphatic invasion. Discussion: The results of our large cohort study, with long term follow up and using multivariate Cox proportional model and comparative design showed a significant prognostic role of vascular invasion in early breast cancer patients. Vascular invasion as an independent prognostic factor in lymph node negative invasive breast cancer.

키워드

참고문헌

  1. Andrulis I, Bull S, Mlackestein M, et al (1998). Neu/erbB-2 amplification identifies a poor prognosis group of women with node negative breast cancer. J Clin Oncol, 16, 1340-9. https://doi.org/10.1200/JCO.1998.16.4.1340
  2. Ashwini N, Budrukkar, Rajiv Sarin, et al (2008). Prognostic factors in node negative premenopausal women treated with breast conserving therapy without adjuvant systemic therapy. The Breast, 17, 263-9. https://doi.org/10.1016/j.breast.2007.10.012
  3. Bekir K, Mithat C, Chamlibel M, et al (2003). Prognostic factors affecting survival and disease free survival in lymph node negative breast carcinoma. J Sur Oncology, 83, 167-72. https://doi.org/10.1002/jso.10264
  4. Camp RL, Rimm EB, Rimm DL, et al (2000). A high number of tumour free axillary lymph nodes from patients with lymph node negative breast carcinoma is associated with poor outcome. Cancer, 88, 108-13. https://doi.org/10.1002/(SICI)1097-0142(20000101)88:1<108::AID-CNCR15>3.0.CO;2-B
  5. Carlmagno C , Perrone F, Gallo C, et al (1996). C-erbB-2 overexpression decreases the benefit of adjuant tamoxifen in early-stage breast cvancer without axillary lymph node metastases. J Clin Oncol, 14, 2702-8. https://doi.org/10.1200/JCO.1996.14.10.2702
  6. Carol SW, H Silberman, Shelley K, et al (2002). lymph node status combined with lymphovascular invasion creats a more powerful tool for predicting outcom in patients with invasive breast cancer. Am J Sur, 184, 337-40. https://doi.org/10.1016/S0002-9610(02)00950-9
  7. Carter CL, Allen C, Henson DE , et al (1989). Relation of tumor size,lymph node status, and survival in 24740 breast cancer. Cancer, 63, 181-7. https://doi.org/10.1002/1097-0142(19890101)63:1<181::AID-CNCR2820630129>3.0.CO;2-H
  8. Clayton G, K Teo, Borg N, et al (2012). Axillary recurrence in breast cancer patients following negative sentinel lymph node biopsy. Eur J Cancer, 48, 223.
  9. Collett K, BO Maehle, Skjaerven R, et al (1994). Lymph node-negative breast cancer: the prognostic role and time dependency of age, tumor diameter and mean nuclear area. Oncology, 51, 323-8. https://doi.org/10.1159/000227358
  10. Fisher B, J Dignam, Wolmark N, et al (1997). Tamoxifen and chemotherapy for lymph node-negative, estrogen receptorpositive breast cancer. J Natl Cancer Inst, 89, 1673-82. https://doi.org/10.1093/jnci/89.22.1673
  11. Florence R, Marc D, Gaetan MacGrogan, et al (2010). Is It Useful to Detect Lymphovascular Invasion in Lymph Node-Positive Patients With Primary Operable Breast Cancer? Cancer, 116, 3093-101. https://doi.org/10.1002/cncr.25137
  12. Fujimori M, Izuo M, Takano A, et al (1968). Prognostic value of vascular invasion in breast cancer. Gan No Rinsho, 14, 389-93.
  13. Gasparini G, Gullick W, Maluta S, et al (1994). C-erbB-3 and cerbB-2 protein expression in node negative breast carcinoma-an immunocytochemical study. Eur J Cancer, 30, 16-22. https://doi.org/10.1016/S0959-8049(05)80010-3
  14. Goldhirsch A, Glick JH, Gelber RD, et al (2001). Meeting hights:international concensus panel on treatment of primary breast cancer. J Clin Oncol, 19, 3817-27. https://doi.org/10.1200/JCO.2001.19.18.3817
  15. Goldhirsch A, William CW, Richard D Gelber, et al (2003). Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer. J Clinical Oncology, 21, 3357-65. https://doi.org/10.1200/JCO.2003.04.576
  16. Goldhrisch A, Glick JH, Gelber RD, et al (2005). Metting hightlights:international expert consensus on the primary therapy of early breast cancer. Ann Oncol, 16, 1659-583.
  17. Goldhirsch A, Wood WC, Gelber RD, et al (2007). Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer 2007. Annals of Oncology, 18, 1133-44. https://doi.org/10.1093/annonc/mdm271
  18. Gurleyik G, Gurleyik E, Aker F, et al (2007). Lymphovascular invasion, as a prognostic marker in patients with invasive breast cancer. Acta Chir Belg, 107, 284-7. https://doi.org/10.1080/00015458.2007.11680057
  19. Gurleyik G, F Aker, Aktekin A, et al (2011). Tumor characteristics influencing non-sentinel lymph node involvement in clinically node negative patients with breast cancer. J Breast Cancer, 14, 124-8. https://doi.org/10.4048/jbc.2011.14.2.124
  20. Kim JY, MR Ryu, Jung DC, et al (2011). The prognostic significance of the lymph node ratio in axillary lymph node positive breast cancer. J Breast Cancer, 14, 204-12. https://doi.org/10.4048/jbc.2011.14.3.204
  21. Kuru B, Camlibel M, Ali Gulcelik M, et al (2003). Prognostic factors affecting survival and disease-free survival in lymph nodenegative breast carcinomas. J Surg Oncol, 83, 167-72. https://doi.org/10.1002/jso.10264
  22. Lauria R, Perrone F, Carlomagna C, et al (1995). The prognostic value of lymphatic and blood vessel invasion in operable breast cancer. Cancer, 76, 1772-8. https://doi.org/10.1002/1097-0142(19951115)76:10<1772::AID-CNCR2820761014>3.0.CO;2-O
  23. Lee HS, BS Kwak, Son BH, et al (2009). Prognostic factors influence on the systemic recurrence in axillary lymph node negative breast cancer. J Korean Sur Society, 77, 238-45. https://doi.org/10.4174/jkss.2009.77.4.238
  24. Mohammed RAA, Ellis IO, Lee AHS, et al (2009). Vascular invasion in breast cancer; an overview of recent prognostic developments and molecular pathophysiological mechanisms. Histopathology, 55, 1-9. https://doi.org/10.1111/j.1365-2559.2008.03169.x
  25. Neville AM, Bettelheim R, Gelber RD, et al (1992). Factors predicting treatment responsiveness and prognosis in nodenegative breast cancer. J Clin Oncol, 10, 696-705. https://doi.org/10.1200/JCO.1992.10.5.696
  26. Nimeus-Malmstrom E, A Koliadi, Ahlin, C, et al (2010). Cyclin B1 is a prognostic proliferation marker with a high reproducibility in a population-based lymph node negative breast cancer cohort. Int J Cancer, 127, 961-7.
  27. Park YS, BS Kwak, Son, BH, et al (2008). Prognostic factors influencing on the distant relapse in axillary lymph node negative breast cancer in Korea. E J Supplements, 6, 184-4.
  28. Pauline TT, CM FRCPC, Freddy Abnousi, et al (2005). Lymphovascular invasion is associated with reduced locoregional control and survival in women with nodenegative breast cancer treated with mastectomy and systemic therapy. J Am Coll Surg, 200, 912-21. https://doi.org/10.1016/j.jamcollsurg.2005.02.010
  29. Pinder SE, Ellis IO, Galea M, et al (1994). Pathological prognostic factors in breast cancer. III. Vascular invasion, relationship with recurrence and survival in a large study with long-term follow-up. Histopathology, 24, 41-7. https://doi.org/10.1111/j.1365-2559.1994.tb01269.x
  30. Polednak AP (2003). Survival of lymph node-negative breast cancer patients in relation to number of lymph nodes examined. Annals of Sur, 237, 163-7.
  31. Port ER, S Patil, Stempel M, et al (2010). Number of lymph nodes removed in sentinel lymph node-negative breast cancer patients is significantly related to patient age and tumor size a new source of bias in morbidity assessment? Cancer, 116, 1987-91. https://doi.org/10.1002/cncr.24964
  32. Sebastian FS, G Bayer, Klaus Aumayr, et al (2004). prognostic value of lymphoangiogenesis and lymphovascular invasion in invasive breast cancer. Annals of Sur, 20, 306-13.
  33. Song YJ, SH Shin, Cho JS, et al (2011). The role of lymphovascular invasion as a prognostic factor in patients with lymph nodepositive operable invasive breast cancer. J Breast Cancer, 14, 198-203. https://doi.org/10.4048/jbc.2011.14.3.198
  34. Teel P (1964). Vascular invasion as a prognostic factor in breast carcinoma. Surg Gynecol Obstet, 118, 1006-8.
  35. Voogd AC, NM, Peterse JL, et al (2001). Differences in risk factors for local and distant recurrence after breastconserving therapy or mastectomy for stage I and II breast cancer, pooled results of two large European randomized trials. J Clin Oncol, 19, 1688-97. https://doi.org/10.1200/JCO.2001.19.6.1688
  36. Woo CS, Silberman H, et al (2002). Lymph node status combined with lymphovascular invasion creates a more powerful tool for predicting outcome in patients with invasive breast cancer. Am J Surg Pathol, 184, 337-40. https://doi.org/10.1016/S0002-9610(02)00950-9
  37. Young J, Shin JS, Cho MH, et al (2011). The role of lymphovascular invasion as a prognostic factor in patients with lymph node positive operable invasive breast cancer. J Breast Cancer, 14, 6.
  38. Yu JB, LD Wilson, Dasgupta T, et al (2008). Postmastectomy radiation therapy for lymph node-negative, locally advanced breast cancer after modified radical mastectomy -analysis of the NCI surveillance, epidemiology and end results database. Cancer, 113, 38-47. https://doi.org/10.1002/cncr.23512
  39. Yuan J, Hennessy C, Givan A, et al (1992). predicting outcom for patients with node negative breast cancer,a comparative study of the value of flow cytometry and cell image analysis for determination of DNA ploidy. Br J Cancer, 65, 461-5. https://doi.org/10.1038/bjc.1992.93

피인용 문헌

  1. Long-Term Survival of Women with Locally Advanced Breast Cancer with ≥10 Involved Lymph Nodes at Diagnosis vol.15, pp.8, 2014, https://doi.org/10.7314/APJCP.2014.15.8.3435
  2. Impact of Age, Tumor Size, Lymph Node Metastasis, Stage, Receptor Status and Menopausal Status on Overall Survival of Breast Cancer Patients in Pakistan vol.16, pp.3, 2015, https://doi.org/10.7314/APJCP.2015.16.3.1019