Asian Pacific Journal of Cancer Prevention

  • 제13권11호
  • /
  • Pages.5849-5855
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Pretreatment Effect of Running Exercise on HSP70 and DOX-Induced Cardiotoxicity

  • Shirinbayan, Vahid (College of Physical Education and Sport Sciences, Department of Sport Physiology, University of Mazandaran) ;
  • Roshan, Valiollah Dabidi (College of Physical Education and Sport Sciences, Department of Sport Physiology, University of Mazandaran)
  • 발행 : 2012.11.30
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초록

Objective: The purpose of this study was to determine pretreatment effects of moderate-term endurance training before the various dosages (10 and $20{_{mg.kg}}^{-1}$) of DOX on a heat shock protein ($HSP_{70kda}$) and cardiotoxicity in heart tissue. Methods: Forty-eight male rats were randomly assigned to nontraining (NT) and training (T) groups and three subgroups; $DOX{_{10mg.kg}}^{-1}$ and $DOX{_{20mg.kg}}^{-1}$ and saline treatment. The training program included treadmill running between 25-39 min/day and 15-17 m/min, 5 days/wk for 3 wk. Result: DOX administration, in particularly with $20{_{mg.kg}}^{-1}$, caused up-regulation of oxidants and cardiac damage (MDA, CK, CPK-MB and CK/CPK-MB) and down-regulation of cardioprotection ($HSP_{70}$, SOD) markers, as compared to NT+saline group. Pretreatment effect of treadmill running endurance exercise in the presence of DOX with $10{_{mg.kg}}^{-1}$ caused a significant increase in $HSP_{70}$, SOD and a significant decrease in MDA and insignificant decrease in CK, CPK-MB and CK/CPK-MB, in comparison $T+DOX_{10}$ with $NT+DOX_{10}$ group. However, there was no significant difference between $T+DOX{_{10mg.kg}}^{-1}$ and $T+DOX{_{20mg.kg}}^{-1}$ in the aforesaid markers. Conclusion: Dox-induced cardiotoxicity is related to oxidative stress. Our study suggests that pretreatment with endurance exercise may be considered as a potentially useful strategy to improve myocardial tolerance against single dose DOX-induced oxidative damage.

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참고문헌

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피인용 문헌

  1. Pretreatment Hepatoprotective Effect of Regular Aerobic Training Against Hepatic Toxicity Induced by Doxorubicin In Rats vol.14, pp.5, 2013, https://doi.org/10.7314/APJCP.2013.14.5.2931
  2. Aerobic exercise in anthracycline-induced cardiotoxicity: a systematic review of current evidence and future directions vol.312, pp.2, 2017, https://doi.org/10.1152/ajpheart.00646.2016
  3. Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity vol.40, pp.3, 2018, https://doi.org/10.1097/MPH.0000000000001112
  4. Aerobic exercise and cardiopulmonary fitness in childhood cancer survivors treated with a cardiotoxic agent: a meta-analysis vol.26, pp.7, 2018, https://doi.org/10.1007/s00520-018-4208-z