DOI QR코드

DOI QR Code

Abortions and Breast Cancer Risk in Premenopausal and Postmenopausal Women in Jiangsu Province of China

  • Jiang, Ai-Ren (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Gao, Chang-Ming (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Ding, Jian-Hua (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Li, Su-Ping (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Liu, Yan-Ting (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Cao, Hai-Xia (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Wu, Jian-Zhong (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Tang, Jin-Hai (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Qian, Yun (Wuxi City Center for Disease Control and Prevention) ;
  • Tajima, Kazuo (Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute)
  • 발행 : 2012.01.31

초록

To evaluate the relationship between abortions and risk of breast cancer, we conducted a case-control study with 669 cases and 682 population-based controls in Jiangsu Province of China. A structured questionnaire was used to elicit detailed information. Unconditional logistic regression analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs). The results have revealed that induced abortion was related to increased risk of breast caner. Premenopausal women who had ${\geq}3$ times of induced abortion were at increased crude OR (2.41, 95%CI: 1.09-5.42) and adjusted-OR (1.55, 95%CI: 1.15-5.68). Postmenopausal women with a previous induced abortion were at increased crude OR (2.04, 95%CI: 1.48-2.81) and adjusted-OR (1.82, 95%CI: 1.30-2.54), and there was a significant increase trend in OR with number of induced abortions (p for trend: 0.0001). Overall, spontaneous abortion did not significantly alter the risk of breast cancer, but postmenopausal women who had history of spontaneous abortion were at increased OR. These results suggested that relationship between breast cancer and abortions may depend on menopausal status and induced abortion may played an important role in the development of breast cancer in Jiangsu' women of China.

키워드

참고문헌

  1. Beral V, Bull D, Doll R, et al (2004). Breast cancer and abortion: collaborative reanalysis of data from 53 epidemiological studies, including 83 000 women with breast cancer from 16 countries. Lancet, 363, 1007-16. https://doi.org/10.1016/S0140-6736(04)15835-2
  2. Brewster DH, Stockton DL, Dobbie R, et al (2005). Risk of breast cancer after miscarriage or induced abortion: a Scottish record linkage case-control study. J Epidemiol Commun Health, 59, 283-7 https://doi.org/10.1136/jech.2004.026393
  3. Brind J, Chinchilli VM, Severs WB, et al (1996). Induced abortion as an independent risk factor for breast cancer: a comprehensive review and meta-analysis. J Epidemiol Commun Health, 50, 481- 96. https://doi.org/10.1136/jech.50.5.481
  4. Chubak J, Tworoger SS, Yasui Y, et al (2004). Associations between reproductive and menstrual factors and postmenopausal sex hormone concentrations. Cancer Epidemiol Biomarkers Prev, 13, 1296-301.
  5. Daling JR, Malone KE, Voigt LF, et al (1994). Risk of breast cancer among young women: relationship to induced abortion. J Natl Cancer Inst, 86, 1569-70. https://doi.org/10.1093/jnci/86.21.1569
  6. Michels KB, Xue F, Colditz GA, et al (2007). Induced and spontaneous abortion and incidence of breast cancer among young women: a prospective cohort study. Arch Intern Med, 167, 814-20. https://doi.org/10.1001/archinte.167.8.814
  7. Naieni KH, Ardalan A, Mahmoodi M, et al (2007). Risk factors of breast cancer in north of Iran: a case-control in Mazandaran Province. Asian Pac J Cancer Prev, 8, 395-8.
  8. Newcomb PA, Storer BE, Longnecker MP, et al (1996). Pregnancy termination in relation to risk of breast cancer. JAMA, 275, 321-2. https://doi.org/10.1001/jama.1996.03530280073041
  9. Ozmen V, Ozcinar B, Karanlik H, et al (2009). Breast cancer risk factors in Turkish women--a University Hospital based nested case control study. World J Surg Oncol, 8, 37.
  10. Palmer JR, Wise LA, Adams-Campbell LL, et al (2004). A prospective study of induced abortion and breast cancer in African-American women. Cancer Causes Control, 15, 105-11. https://doi.org/10.1023/B:CACO.0000019484.29558.f7
  11. Paoletti X, Clavel-Chapelon F, E3N group (2003). Induced and spontaneous abortion and breast cancer risk: Results from the E3N cohort study. Int J Cancer, 106, 270-6. https://doi.org/10.1002/ijc.11203
  12. Parkin DM, Bray F, Ferlay J, Pisani P (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  13. Remennick LI (1990). Induced abortion as cancer risk factor: a review of epidemiological evidence. J Epidemiol Commun Health, 44, 259-64. https://doi.org/10.1136/jech.44.4.259
  14. Russo J, Russo IH (1980). Susceptibility of the mammary gland to carcinogenesis. II. Pregnancy interruption as a risk factor in tumor incidence. Am J Pathol, 100, 497-512.
  15. Yang L, Parkin DM, Ferlay J, et al (2005). Estimates of Cancer Incidence in China for 2000 and Projections for 2005. Cancer Epidemiol Biomarkers Prev, 14, 243-50.
  16. Ye Z, Gao DL, Qin Q, et al (2002). Breast cancer in relation to induced abortions in a cohort of Chinese women. Br J Cancer, 87, 977- 81. https://doi.org/10.1038/sj.bjc.6600603

피인용 문헌

  1. Abortion-breast cancer study not valid for assessing overall association vol.92, pp.12, 2013, https://doi.org/10.1111/aogs.12219
  2. Induced Abortion and Breast Cancer: Results from a Population-Based Case Control Study in China vol.15, pp.8, 2014, https://doi.org/10.7314/APJCP.2014.15.8.3635
  3. A meta-analysis of the association between induced abortion and breast cancer risk among Chinese females vol.25, pp.2, 2014, https://doi.org/10.1007/s10552-013-0325-7
  4. The breast cancer epidemic: 10 facts vol.81, pp.3, 2014, https://doi.org/10.1179/2050854914Y.0000000027
  5. Comparison of Breast Cancer Risk Predictive Models and Screening Strategies for Chinese Women vol.26, pp.3, 2017, https://doi.org/10.1089/jwh.2015.5692
  6. Intron 4 VNTR (4a/b) Polymorphism of the Endothelial Nitric Oxide Synthase Gene Is Associated with Breast Cancer in Mexican Women vol.28, pp.11, 2013, https://doi.org/10.3346/jkms.2013.28.11.1587
  7. Induced abortion and breast cancer vol.97, pp.3, 2018, https://doi.org/10.1097/MD.0000000000009613