Asian Pacific Journal of Cancer Prevention

  • 제13권1호
  • /
  • Pages.111-115
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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XRCC1-77T>C Polymorphism and Cancer Risk: A Meta-analysis

  • Wang, Yong-Gang (Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University) ;
  • Zheng, Tian-Ying (Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University)
  • 발행 : 2012.01.31
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초록

Variants of X-ray repair cross-complementing group 1 (XRCC1) are involved in the development of cancer, but studies investigating the association of XRCC1-77T>C polymorphism with cancer risk have reported conflicting results. To clarify the effect of the XRCC1 -77T>C polymorphism on cancer risk, we performed a meta-analysis by conducting searches of the published literature in PubMed, Embase and CBM databases. Finally, 13 studies were included into our meta-analysis, involving a total of 11, 678 individuals. Subgroup analyses were performed by ethnicity and cancer type. The results of this meta-analysis showed that there was significant association between the C variant of XRCC1-77T>C polymorphism and cancer risk in all four genetic comparison models (ORC vs. T =1.19, 95%CI 1.07-1.31, P = 0.001; OR homozygote model =1.28, 95%CI 1.07-1.52, P = 0.007; OR recessive genetic model =1.22, 95%CI 1.04-1.44, P = 0.015; OR dominant model =1.21, 95% CI 1.07-1.35, P = 0.001). In the subgroup analyses based on ethnicity, the association was still significant in the Asian population (all p values<0.001), but not in the Caucasian population (all p values > 0.05). Thus, the XRCC1 -77T>C polymorphism is associated with cancer risk, and individuals with XRCC1 -77C variant have a significantly higher cancer risk, particularly in the Asian population.

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참고문헌

  1. Almeida KH, Sobol RW (2007). A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. DNA Repair, 6, 695-711. https://doi.org/10.1016/j.dnarep.2007.01.009
  2. Basso D, Navaglia F, Fogar P, et al (2007). DNA repair pathways and mitochondrial DNA mutations in gastrointestinal carcinogenesis. Clin Chimica Acta, 381, 50-5. https://doi.org/10.1016/j.cca.2007.02.020
  3. Betti M, Ferrante D, Padoan M, et al (2011). XRCC1 and ERCC1 variants modify malignant mesothelioma risk: a case-control study. Mutation Res, 708, 11-20. https://doi.org/10.1016/j.mrfmmm.2011.01.001
  4. Brem R, Cox DG, Chapot B, et al (2006). The XRCC1 -77T- >C variant: haplotypes, breast cancer risk, response to radiotherapy and the cellular response to DNA damage. Carcinogenesis, 27, 2469-74. https://doi.org/10.1093/carcin/bgl114
  5. Campalans A, Marsin S, Nakabeppu Y, et al (2005). XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair. DNA Repair, 4, 826-35. https://doi.org/10.1016/j.dnarep.2005.04.014
  6. Cochran WG (1954). The combination of estimates from different experiments. Biometrics, 10, 101-29. https://doi.org/10.2307/3001666
  7. Corso G, Marrelli D, Pedrazzani C, et al (2009). Gastric cardia carcinoma is associated with the promoter -77T>C gene polymorphism of X-ray cross-complementing group 1 (XRCC1). J Gastrointest Surg, 13, 2233-8. https://doi.org/10.1007/s11605-009-0980-x
  8. Dai L, Wang K, Zhang J, et al (2009). XRCC1 gene polymorphisms and esophageal squamous cell carcinoma risk in Chinese population: A meta-analysis of case-control studies. Int J Cancer, 125, 1102-9. https://doi.org/10.1002/ijc.24446
  9. Das A, Wiederhold L, Leppard JB, et al (2006). NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. DNA Repair, 5, 1439-48. https://doi.org/10.1016/j.dnarep.2006.07.003
  10. DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Controlled Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  11. De Ruyck K, Szaumkessel M, De Rudder I, et al (2007). Polymorphisms in base-excision repair and nucleotideexcision repair genes in relation to lung cancer risk. Mutation Res, 631, 101-10. https://doi.org/10.1016/j.mrgentox.2007.03.010
  12. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  13. Ginsberg G, Angle K, Guyton K, et al (2011). Polymorphism in the DNA repair enzyme XRCC1: utility of current database and implications for human health risk assessment. Mutation Res, 727, 1-15. https://doi.org/10.1016/j.mrrev.2011.02.001
  14. Hao B, Miao X, Li Y, et al (2006). A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Oncogene, 25, 3613-20. https://doi.org/10.1038/sj.onc.1209355
  15. Hao B, Wang H, Zhou K, et al (2004). Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. Cancer Res, 64, 4378-84. https://doi.org/10.1158/0008-5472.CAN-04-0372
  16. Hsieh WC, Cheng YW, Lin CJ, et al (2009). Prognostic significance of X-ray cross-complementing group 1 T-77C polymorphism in resected non-small cell lung cancer. Jpn J Clinic Oncol, 39, 81-5.
  17. Huang Y, Li L, Yu L (2009). XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms in breast cancer risk: a metaanalysis. Mutagenesis, 24, 331-9. https://doi.org/10.1093/mutage/gep013
  18. Hu Z, Ma H, Lu D, et al (2005). A promoter polymorphism (-77T>C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking. Pharmacogenet Genomics, 15, 457-63. https://doi.org/10.1097/01.fpc.0000167329.85163.0d
  19. Lao T, Gu W, Huang Q (2008). A meta-analysis on XRCC1 R399Q and R194W polymorphisms, smoking and bladder cancer risk. Mutagenesis, 23, 523-32. https://doi.org/10.1093/mutage/gen046
  20. Li M, Yin Z, Guan P, et al (2008). XRCC1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers. Lung Cancer, 62, 145-51. https://doi.org/10.1016/j.lungcan.2008.03.002
  21. Liu L, Yuan P, Wu C, et al (2011). A functional -77T>C polymorphism in XRCC1 is associated with risk of breast cancer. Breast Cancer Res Treat, 125, 479-87. https://doi.org/10.1007/s10549-010-0959-z
  22. Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
  23. Sak SC, Barrett JH, Paul AB, et al (2007). DNA repair gene XRCC1 polymorphisms and bladder cancer risk. BMC Genetics, 8, 13. https://doi.org/10.1186/1471-2156-8-13
  24. Sterpone S, Mastellone V, Padua L, et al (2010). Singlenucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women. J Cancer Res Clin Oncol, 136, 631-6. https://doi.org/10.1007/s00432-010-0791-1
  25. Tudek B (2007). Base excision repair modulation as a risk factor for human cancers. Mol Aspects Med, 28, 258-75. https://doi.org/10.1016/j.mam.2007.05.003
  26. Vidal AE, Boiteux S, Hickson ID, et al (2001). XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions. EMBO J, 20, 6530-9. https://doi.org/10.1093/emboj/20.22.6530
  27. Wang M, Qin C, Zhu J, et al (2010). Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer. DNA Cell Biol, 29, 303-11. https://doi.org/10.1089/dna.2009.0969

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  2. Lack of association between XRCC3 rs861539 (C > T) polymorphism and lung cancer risks: an update meta-analysis vol.34, pp.3, 2013, https://doi.org/10.1007/s13277-013-0722-2
  3. XRCC3 C18067T Polymorphism Contributes a Decreased Risk to Both Basal Cell Carcinoma and Squamous Cell Carcinoma: Evidence from a Meta-Analysis vol.9, pp.1, 2014, https://doi.org/10.1371/journal.pone.0084195
  4. Polymorphisms of the XRCC1 gene and breast cancer risk in the Mexican population vol.14, pp.3, 2015, https://doi.org/10.1007/s10689-015-9787-y