Asian Pacific Journal of Cancer Prevention

  • 제13권1호
  • /
  • Pages.191-194
  • /
  • 2012
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Evaluation of DNA Repair Gene XRCC1 Polymorphism in Prediction and Prognosis of Hepatocellular Carcinoma Risk

  • Li, Qiu-Wen (Oncology Department, No 1 Hospital Affiliated to the General Hospital of the Chinese People's Liberation Army) ;
  • Lu, Can-Rong (General Hospital of the Chinese People's Liberation Army) ;
  • Ye, Ming (Oncology Department, No 1 Hospital Affiliated to the General Hospital of the Chinese People's Liberation Army) ;
  • Xiao, Wen-Hua (Oncology Department, No 1 Hospital Affiliated to the General Hospital of the Chinese People's Liberation Army) ;
  • Liang, Jun (Department of Oncology, the Affiliated Hospital, Medical College of Qingdao University)
  • 발행 : 2012.01.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

We conducted a case-control study in China to clarify the association between XRCC1-Arg399Gln polymorphism and HCC risk. A total of 150 cases and 158 controls were selected from the the Affiliated Hospital of Qingdao University from May 2008 to May 2010. XRCC1-Arg399Gln polymorphism was based upon duplex polymerase-chain-reaction with the confronting-two-pairprimer (PCR-CTPP) method. All analyses were performed using the STATA statistical package. A significantly increased risk was associated with the Arg/Gln genotype (adjusted OR 1.78, 95%CI=1.13-2.79) compared with genotype Arg/Arg. In contrast, the Gln/Gln genotype had non-significant increased risk of HCC with adjusted OR (95%CI) of 1.69 (0.93-2.66). A significant association was found between positive HBsAg and Arg/Gln, with an OR of 3.43 (95% CI=1.45-8.13). Patients carrying Gln/Gln genotypes showed significantly lower median survival than Arg/Arg genotypes (HR=1.38, 95% CI=1.04-1.84). Further Kaplan-Meier analysis showed decreased median survival in Arg/Gln+Gln/Gln genotype carriers in comparison to Arg/Arg carriers (HR=1.33, 95% CI=1.02-1.76). In conclusion, we observed that XRCC1-Arg399Cln polymorphism is associated with susceptibility to HCC, and XRCC1 Gln allele genotype showed significant prognostic associations.

키워드

참고문헌

  1. Ang MK, Patel MR, Yin XY, et al (2010). Expression and prognostic significance of X-ray crosscomplementation group 1 (XRCC1) in head and neck squamous cell carcinoma patients undergoing concurrent chemoradiation. J Clin Oncol, suppl, 5541.
  2. Audebert M, Salles B, Calsou P (2004). Involvement of poly(- ADP-ribose)polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem, 279, 117-26. https://doi.org/10.1074/jbc.M307955200
  3. Basso D, Navaglia F, Fogar P, et al (2007). DNA repair pathways and mitochondrial DNA mutations in gastrointestinal carcinogenesis. Clin Chim Acta, 381, 50-5. https://doi.org/10.1016/j.cca.2007.02.020
  4. Clot P, Tabone M, Arico S, et al (1994). Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake. Gut, 35, 1637-43. https://doi.org/10.1136/gut.35.11.1637
  5. Geng J, Zhang YW, Huang GC, et al (2008). XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A metaanalysis. World J Gastroenterol, 14, 6733-7. https://doi.org/10.3748/wjg.14.6733
  6. Grimminger PP, Brabender J, Warnecke-Eberz U, et al (2010). XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer. J Surg Res, 164, e61-6. https://doi.org/10.1016/j.jss.2010.08.002
  7. Han J, Hankinson SE, Colditz GA, et al (2004). Genetic variation in XRCC1, sun exposure and risk of skin cancer. Br J Cancer, 91, 1604-9. https://doi.org/10.1038/sj.bjc.6602174
  8. International Agency for Research on Cancer: Liver Cancer Incidence and Mortality Worldwide in 2008. 2011, http://globocan.iarc.fr/factsheets/cancers/liver.asp
  9. Ishii H, Kurose I, Kato S (1997). Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress. J Gastroenterol Hepatol, 12, S272-82. https://doi.org/10.1111/j.1440-1746.1997.tb00510.x
  10. Kiyohara C, Takayama K, Nakanishi Y (2010). Lung cancer risk and genetic polymorphisms in DNA repair pathways: A meta-analysis. J Nucleic Acids, 2010,701760.
  11. Kiran M, Saxena R, Chawla YK, et al (2009). Polymorphism of DNA repair gene XRCC1 and hepatitis-related hepatocellular carcinoma risk in Indian population. Mol Cell Biochem, 327, 7-13. https://doi.org/10.1007/s11010-009-0035-3
  12. Liu F, Li B, Wei Y, et al (2011). XRCC1 genetic polymorphism Arg399Gln and hepatocellular carcinoma risk: a metaanalysis. Liver Int, 31, 802-9. https://doi.org/10.1111/j.1478-3231.2011.02508.x
  13. Long XD, Ma Y, Zhou YF, Ma AM, Fu GH (2010). Polymorphism in xeroderma pigmentosum complementation group C codon 939 and aflatoxin B1-related hepatocellular carcinoma in the Guangxi population. Hepatology, 52, 1301-9. https://doi.org/10.1002/hep.23807
  14. Navasumrit P, Ward TH, Dodd NJ, et al (2000). Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants: effects of acute and chronic ethanol exposure. Carcinogenesis, 21, 93-9. https://doi.org/10.1093/carcin/21.1.93
  15. Nordmann R, Ribiere C, Rouach H (1992). Implication of free radical mechanisms in ethanol-induced cellular injury. Radic Biol Med, 12, 219-40. https://doi.org/10.1016/0891-5849(92)90030-K
  16. Ott K, Rachakonda PS, Panzram B, et al (2011). DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy. Ann Surg Oncol, 18, 2688-98. https://doi.org/10.1245/s10434-011-1601-y
  17. Pan HZ, Liang J (2011). XRCC1-Arg399Gln of DNA repair gene XRCC1 and hepatocellular carcinoma risk in Chinese population. Asian Pac J Cancer Prev, 12, in press.
  18. Rajaraman P, Hutchinson A, Wichner S, et al (2010). DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Neuro Oncol, 12, 37-48. https://doi.org/10.1093/neuonc/nop012
  19. Rybarova S, Vecanova J, Hodorova I, et al (2011). Association between polymorphisms of XRCC1, p53 and MDR1 genes, the expression of their protein products and prognostic significance in human breast cancer. Med Sci Monit, 17, BR354-63.
  20. Sakano S, Wada T, Matsumoto H, et al (2006). Single nucleotide polymorphisms in DNA repair genes might be prognostic factors in muscle-invasive bladder cancer patients treated with chemoradiotherapy. Br J Cancer, 95, 561-70. https://doi.org/10.1038/sj.bjc.6603290
  21. Shen MR, Jones IM, Mohrenweiser H (1998). Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res, 58, 604-8.
  22. Thompson LH, Brookman KW, Jones NJ, et al (1990). Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. Mol Cell Biol, 10, 6160-71. https://doi.org/10.1128/MCB.10.12.6160
  23. Tudek B (2007). Base excision repair modulation as a risk factor for human cancers. Mol Aspects Med, 28, 258-75. https://doi.org/10.1016/j.mam.2007.05.003
  24. Yin M, Tan DF, Wei QY (2009). Genetic variants of the XRCC1 gene and susceptibility to esophageal cancer: a metaanalysis. Int J Clin Exp Med, 2, 26-35.
  25. Yu HP, Zhang XY, Wang XL, et al (2004). DNA repair gene XRCC1 polymorphisms, smoking and esophageal cancer risk. Cancer Detect Prev, 28, 194-9. https://doi.org/10.1016/j.cdp.2004.01.004
  26. Yu MW, Yang SY, Pan IJ, et al (2003). Polymorphisms in XRCCl and Glutathione S-Transferase Genes and Hepatitis B-Related Hepatocellular Carcinoma. J Natl Cancer Inst, 95, 1485-8. https://doi.org/10.1093/jnci/djg051
  27. Zipprich J, Terry MB, Brandt-Rauf P, et al (2010). XRCC1 polymorphisms and breast cancer risk from the New York Site of the Breast Cancer Family Registry: A family-based case-control study. J Carcinog, 9, 4. https://doi.org/10.4103/1477-3163.62535

피인용 문헌

  1. ADPRT Val762Ala and XRCC1 Arg194Trp Polymorphisms and Risk of Gastric Cancer in Sichuan of China vol.13, pp.5, 2012, https://doi.org/10.7314/APJCP.2012.13.5.2139
  2. Association of XPD and XRCC1 Genetic Polymorphisms with Hepatocellular Carcinoma Risk vol.13, pp.9, 2012, https://doi.org/10.7314/APJCP.2012.13.9.4423
  3. The XRCC1 Arg399Gln Genetic Polymorphism Contributes to Hepatocellular Carcinoma Susceptibility: An Updated Meta-analysis vol.14, pp.10, 2013, https://doi.org/10.7314/APJCP.2013.14.10.5761
  4. Polymorphisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: a meta-analysis vol.34, pp.1, 2013, https://doi.org/10.1007/s13277-012-0546-5
  5. An Updated Meta-analysis Between the Association of XRCC1 Arg399Gln Polymorphism and Hepatocellular Carcinoma Risk vol.15, pp.7, 2014, https://doi.org/10.7314/APJCP.2014.15.7.3273
  6. Association analysis between the c.1804C>A genetic polymorphism of XRCC1 gene and risk of hepatocellular carcinoma in Chinese population vol.31, pp.3, 2014, https://doi.org/10.1007/s12032-014-0854-2
  7. Genetic polymorphisms of XRCC1 gene and susceptibility to hepatocellular carcinoma in Chinese population vol.31, pp.4, 2014, https://doi.org/10.1007/s12032-014-0887-6
  8. Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study vol.15, pp.23, 2014, https://doi.org/10.7314/APJCP.2014.15.23.10209
  9. Variant Alleles in XRCC1 Arg194Trp and Arg399Gln Polymorphisms Increase Risk of Gastrointestinal Cancer in Sabah, North Borneo vol.17, pp.4, 2016, https://doi.org/10.7314/APJCP.2016.17.4.1925
  10. Novel targeting of the lepB gene using PCR with confronting two-pair primers for simultaneous detection of Mycobacterium tuberculosis complex and Mycobacterium bovis vol.65, pp.1, 2016, https://doi.org/10.1099/jmm.0.000188
  11. Polymorphism in XRCC1 gene modulates survival and clinical outcomes of advanced North Indian lung cancer patients treated with platinum-based doublet chemotherapy vol.34, pp.4, 2017, https://doi.org/10.1007/s12032-017-0923-4
  12. Associations between three XRCC1 polymorphisms and hepatocellular carcinoma risk: A meta-analysis of case-control studies vol.13, pp.11, 2018, https://doi.org/10.1371/journal.pone.0206853
  13. The Association of XRCC1 Gene Polymorphisms and Chronic Hepatitis C Induced Insulin Resistance in Egyptian Patients vol.7, pp.11, 2018, https://doi.org/10.3390/cells7110185