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TP53 Codon 72 Polymorphism and Risk of Acute Leukemia

  • Dunna, Nageswara Rao (School of Chemical & Biotechnology, SASTRA University) ;
  • Vure, Sugunakar (Department of Genetics, Osmania University) ;
  • Sailaja, K. (Department of Genetics, Osmania University) ;
  • Surekha, D. (Department of Genetics, Osmania University) ;
  • Raghunadharao, D. (Department of Medical Oncology, Nizams Institute of Medical Sciences) ;
  • Rajappa, Senthil (Department of Medical Oncology, Nizams Institute of Medical Sciences) ;
  • Vishnupriya, S. (Department of Genetics, Osmania University)
  • 발행 : 2012.01.31

초록

TP53 is the mostly commonly mutated gene in many cancers and the P53 tumor suppressor protein is involved in multiple cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle control and apoptosis. A common single nucleotide polymorphism located within the proline rich region of TP53 gene at codon 72 in exon 4 encodes either proline or arginine. TP53 Arg 72 is more active than TP53 Pro 72 in inducing apoptosis. The aim of this study was to understand the association of the 72 codon polymorphism with acute leukemia development and prognosis. A total of 288 acute leukemia cases comprising 147 acute lymphocytic leukemia (ALL) and 141 acute myeloid leukemia (AML), as well as 245 controls were recruited for analysis of the TP53 72 polymorphism using PCR-RFLP method. Significant association of homozygous arginine genotype with AML was observed (${\chi}^2$- 133.53; df-2, p < 0.001. When data were analyzed with respect to clinical variables, elevation in mean WBC, blast %, LDH levels and slight reduction in DFS in ALL cases with the arginine genotype was observed. In contrast, AML patients with Pro/Pro had elevated WBC, Blast%, LDH levels with slightly reduced DFS. Our study indicates that Arg/Arg genotype might confer increased risk to development of acute myeloid leukemia.

키워드

참고문헌

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피인용 문헌

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  2. RNA-Seq analysis identifies aberrant RNA splicing of TRIP12 in acute myeloid leukemia patients at remission vol.35, pp.10, 2014, https://doi.org/10.1007/s13277-014-2228-y
  3. No evidence of correlation between p53 codon 72 G > C gene polymorphism and cancer risk in Indian population: a meta-analysis vol.35, pp.9, 2014, https://doi.org/10.1007/s13277-014-2114-7
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  6. mutation in patients with high-risk acute myeloid leukaemia treated with allogeneic haematopoietic stem cell transplantation vol.172, pp.6, 2016, https://doi.org/10.1111/bjh.13912
  7. Association between TP53 Arg72Pro polymorphism and leukemia risk: a meta-analysis of 14 case-control studies vol.6, pp.1, 2016, https://doi.org/10.1038/srep24097
  8. acute myeloid leukaemia - results of two cohort studies involving 215 patients and 3759 controls pp.00071048, 2018, https://doi.org/10.1111/bjh.14527