Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
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Clinical and Endoscopic Findings in Children with Peptic Ulcer in Terms of $Helicobacter$ $pylori$ in Incheon

  • Cho, Sang-Hee (Department of Pediatrics, Hanil General Hospital) ;
  • Chun, Ka-Yeong (Ilsan Dong-gu Community Health Center) ;
  • Ryoo, Eell (Department of Pediatrics, Gil Hospital, Gachon University) ;
  • Kim, Yeun-Sun (Department of Internal Medicine, Gil Hospital, Gachon University) ;
  • Tchah, Hann (Department of Pediatrics, Gil Hospital, Gachon University)
  • Received : 2011.12.29
  • Accepted : 2012.02.29
  • Published : 2012.03.30
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Abstract

Purpose: Interest in peptic ulcer in children has been relatively low because the disease is rarer in children than in adults and there were restrictions in the application of endoscopy to children, but the recent development of pediatric endoscopy is activating research on pediatric peptic ulcer. Thus, this study compared the $H.$ $pylori$ infection rate and clinical and endoscopic findings among pediatric patients diagnosed with peptic ulcer. Methods: We analyzed retrospectively 58 pediatric patients for whom whether to be infected with $H.$ $pylori$ was confirmed selected out of pediatric patients diagnosed with gastric ulcer or duodenal ulcer through upper gastrointestinal endoscopy at the Department of Pediatrics of Gachon University Gil Hospital during the period from January 2002 to December 2007. A case was considered $H.$ $pylori$ positive if $H.$ $pylori$ was detected in the Giemsa stain of tissue or the results of UBT (urea breath test) and CLO (rapid urease test) were both positive. Results: Of the pediatric patients, 37 were infected with $H.$ $pylori$ and 21 were not. The $H.$ $pylori$ infection rate increased with aging and the result was statistically significant ($p$<0.05). However, $H.$ $pylori$ infection was not in a statistically significant correlation with sex, chief complaint, and gastroduodenal ulcer ($p$>0.05). Conclusion: $H.$ $pylori$ infection increased with aging, but was not significantly correlated with gastroduodenal ulcer. Further research may need to examine prospectively the relation between $H.$ $pylori$ and gastroduodenal ulcer in the Incheon area.

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References

  1. Lee A, O'Rourke J. Gastric bacteria other than Helicobacter pylori. Gasttoenterol Clin North Am 1993;22:21-42.
  2. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984;1:1311-5.
  3. Douglas OF, Emma EF, Marcia C, James G, David CM. Histological predictors of active Helicobacter pylori infection. Dig Dis Sci 1996;41:937-43.
  4. Sarker SA, Mahmud H, Davidsson L, Alam NH, Ahmed T, Alam N, et al. Causal relationship of Helicobacter pylori with iron‐deficiency anemia or failure of iron supplementation in children. Gastroenterology 2008;135:1534-42.
  5. Hill ID, Sinclair-Smith C, Lastovica AJ, Bowie MD, Emms M. Transient protein losing enteropathy associated with acute gastritis and Campylobacter pylori. Arch Dis Child 1987;62:1215-9.
  6. Kato S, Sherman PM. What is new related to Helicobacter pylori infection in children and teenagers? Arch Pediatr Adolesc Med 2005;159:415-21.
  7. Sullivan PB, Thomas JE, Weight DG, Neale G, Eastham EJ, Corrah T, et al. Helicobacter pylori in Gambian children with chronic diarrhea and malnutrition. Arch Dis Child 1990;65:189-91.
  8. Rhee KS, Park JO. Gastroduodenoscopic findings and effect of therapy of Helicobacter pylori infection in children. Korean J Pediatr Gastroenterol Nutr 2005;8:12-20.
  9. Seo JK. Recurrent abdominal pain in children. J Korean Med Assoc 1999;42:859-67.
  10. Valle J, Kekki M, Sipponen P, Ihamaki T, Siurala M. Long‐term course and consequences of Helicobacter pylori gastritis. Results of a 32-year follow-up study. Scand J Gastroenterol 1996;31:546-50.
  11. Wedd PM, Knight T, Greaves S, Wilson A, Newell DG, Elder J, et al. Relation between infection with Helicobacter pylori and living condition in childhood: evidence for person to person transmission in early life. BMJ 1994;308:750-3.
  12. Jung MK, Kwon YS, Choe H, Choe YH, Hong YC. Relation between Helicobacter pylori infection and socioeconomic status in Korean adolescents. Korean J Pediatr Gastroenterol Nutr 2000;3:17-22.
  13. Megraud F, Lamouliatte H. Helicobacter pylori and duodenal ulcer: Evidence suggesting causation. Dig Dis Sci 1992;37:769-72.
  14. Yom HW, Seo JW. Gastric mucosal immune response of Helicobacter pylori -infected children. Korean J Pediatr 2008;51:457-64.
  15. Barthel JS, Everett ED. Diagnosis of Campylobacter pylori infections: The "gold standard" and the alternatives. Rev Infect Dis 1990;12:s107-14.
  16. Brown KE, Peura DA. Diagnosis of Helicobacter pylori infection. Gastroenterol Clin Nor Am 1993;22:105-15.
  17. Egbaria R, Levine A, Tamir A, Shaoul R. Peptic ulcers and erosions are common in Israel children undergoing upper endoscopy. Helicobacter 2008;13:62-8.
  18. Bittencourt PF, Rocha GA, Penna FJ, Queiroz DM. Gastroduodenal peptic ulcer and Helicobacter pylori infection in children and adolescents. J Pediatr 2006;82:325-34.
  19. Kim YJ. Gastrointestinal mucosal lesions in children with short‐term abdominal pain. Korean J Pediatr Gastroenterol Nutr 2006;9:176-82.
  20. Lee SL, Kim YS, Suh ES, Paik TW, Kang CM. A clinical study on peptic ulcer in childhood. J Korean Pediatr Soc 1989;32:198-205.
  21. Park IS, Kim NS, Jung PM. Peptic ulcer disease in infants and children. J Korean Pediatr Soc 1995;38:339-46.
  22. Choe YH, Ko JS, Kim SY, Yoo YM, Seo JK. The eradication of Helicobacter pylori in the duodenal ulcer in children and the duodenal recurrence. Korean J Pediatr Gastroenterol Nutr 1998;1:30-6.
  23. Drumm B, Perez-Perez GI, Blaser MJ. Intrafamilial clustering of Helicobacter pylori infection. N Engl J Med 1990;322:359-63.
  24. Hassel E, Dimmick JE. Unique features of Helicobacter pylori disease in children. Dig Dis Sci 1991;36:417-23.
  25. Drumm B, O'Brien A, Cutz E, Sherman P. Campylobacter pylori-associated primary gastritis in children. Pediatrics 1987;80:192-5.
  26. Kilbridge PM, Dahms BB, Czinn SJ. Campylobacter pylori-associated gastritis and peptic ulcer disease in children. Am J Dis Child 1988;142:1149-52.
  27. Aeri M, Aliza S, Debra B, Susanna CR. Positive association between Helicobacter pylori and gastroesophageal reflux disease in children. J Pediatr Gastroenterol Nutr 2009;49:283-8.
  28. Kim HJ, Han HJ, An SG, Yoo JS, Kim HS, Tchah H, et al. Clinical and endoscopic findings in children with duodenal ulcer due to Helicobacter pylori infection. J Korean Pediatr Soc 1999;42:69-76.