Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Sokmyong-tang on Ferric Chloride-induced Carotid Injury and Thrombosis in a Rat Model

경동맥 손상 및 혈전을 유발한 동물 모델에서 속명탕(續命湯)의 효능 검증

  • Heo, Eun Jung (Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, In Sun (Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kang, Hyung Won (Department of Neuropsychiatry, College of Oriental Medicine, Won-Kwang University) ;
  • Jeon, Won Kyung (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
  • 허은정 (한국한의학연구원 한의신약연구그룹) ;
  • 이인선 (한국한의학연구원 한의신약연구그룹) ;
  • 강형원 (원광대학교 한의과대학 한방신경정신과교실) ;
  • 전원경 (한국한의학연구원 한의신약연구그룹)
  • Received : 2012.09.12
  • Accepted : 2012.10.04
  • Published : 2012.10.25
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Abstract

The aim of this study is examine the protection effect for artery and antithrombotic effect of Sokmyong-tang(SMT; xuming-tang) on carotid artery thrombosis in a rat model. Thirty minutes before $FeCl_3$ treatment, SD rats were intraperitoneal injected with SMT. We tested the effects of SMT on time to occlusion (TTO) in thrombosis model by induced $FeCl_3$ using the laser Doppler flow meter and accessed thrombus weight (TW) inhibition and measured collagen fibers in the vessel after injury using Masson's trichrome stain. SMT(100 mg/kg, i.p.) showed significantly delayed TTO ($13.17{\pm}1.33$ min, P < 0.001) compared to vehicle control group ($8.63{\pm}0.92$ min) and inhibiting effect on TW with $0.72{\pm}0.02$ mg/mm (P < 0.05). In addition, SMT prevented collagen fibres damage in injured vessel ($22.24{\pm}4.48%$, P < 0.001). These results provide experimental evidence for SMT can be used to prevent vascular injury and thrombosis such as hypertension, arteriosclerosis, and so on.

Keywords

Acknowledgement

Supported by : 기초기술연구회, 한국한의학연구원

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