The Korean Journal of Physiology and Pharmacology

  • 제16권3호
  • /
  • Pages.219-224
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  • 2012
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
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Gap Junction Contributions to the Goldfish Electroretinogram at the Photopic Illumination Level

  • Kim, Doh-Yeon (Natural Sciences Section, Department of Medical Lifescience, College of Medicine, The Catholic University of Korea) ;
  • Jung, Chang-Sub (Natural Sciences Section, Department of Medical Lifescience, College of Medicine, The Catholic University of Korea)
  • 투고 : 2012.05.03
  • 심사 : 2012.05.30
  • 발행 : 2012.06.30
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초록

Understanding how the b-wave of the electroretinogram (ERG) is generated by full-field light stimulation is still a challenge in visual neuroscience. To understand more about the origin of the b-wave, we studied the contributions of gap junctions to the ERG b-wave. Many types of retinal neurons are connected to similar and different neighboring neurons through gap junctions. The photopic (cone-dominated) ERG, stimulated by a small light beam, was recorded from goldfish (Carassius auratus) using a corneal electrode. Data were obtained before and after intravitreal injection of agents into the eye under a photopic illumination level. Several agents were used to affect gap junctions, such as dopamine D1 and D2 receptor agonists and antagonists, a nitric oxide (NO) donor, a nitric oxide synthase (NOS) inhibitor, the gap junction blocker meclofenamic acid (MFA), and mixtures of these agents. The ERG b-waves, which were enhanced by MFA, sodium nitroprusside (SNP), SKF 38393, and sulpiride, remained following application of a further injection of a mixture with MFA. The ERG b-waves decreased following $N^G$-nitro-L-arginine methyl ester (L-NAME), SCH 23390, and quinpirole administration but were enhanced by further injection of a mixture with MFA. These results indicate that gap junction activity influences b-waves of the ERG related to NO and dopamine actions.

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