Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-inflmmatory Effects of Scutellaria baicalensis Georgi Water Extract in the THP-1 Cells Activated by Advanced Glycation End Products

황금 물추출물의 당화종말산물로 유도한 THP-1 세포의 염증반응 억제효과

  • Park, Pyeong-Beom (Department of Pathology, College of Oriental Medicine, Woosuk University) ;
  • Kim, Min-Jun (Department of Pathology, College of Oriental Medicine, Woosuk University) ;
  • Shin, Kyoung-Ho (Department of Pathology, College of Oriental Medicine, Woosuk University) ;
  • Lee, Kwang-Gyu (Department of Pathology, College of Oriental Medicine, Woosuk University) ;
  • Lee, Chang-Hyun (Department of Anatomy, College of Oriental Medicine, Woosuk University) ;
  • Lee, Sang-Ryong (Department of Meridian & Acupoint, College of Oriental Medicine, Woosuk University) ;
  • Ha, Ki-Tae (Division of Applied Medicine, School of Korean Medicine, Pusan National University) ;
  • Jeong, Han-Sol (Division of Applied Medicine, School of Korean Medicine, Pusan National University)
  • 박평범 (우석대학교 한의과대학 병리학교실) ;
  • 김민준 (우석대학교 한의과대학 병리학교실) ;
  • 신경호 (우석대학교 한의과대학 병리학교실) ;
  • 이광규 (우석대학교 한의과대학 병리학교실) ;
  • 이창현 (우석대학교 한의과대학 해부학교실) ;
  • 이상룡 (우석대학교 한의과대학 경혈학교실) ;
  • 하기태 (부산대학교 한의학전문대학원 응용의학부) ;
  • 정한솔 (부산대학교 한의학전문대학원 응용의학부)
  • Received : 2012.05.02
  • Accepted : 2012.06.16
  • Published : 2012.06.25
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Abstract

Scutellaria baicalensis Georgi, which has been known to be able to clear away heat and remove dampness, was used for febrile disease. It is now clear that Advanced glycation end products (AGEs) play major roles in the pathogenesis of diabetic complications such as atherosclerosis. In this study, we examined whether Scutellaria baicalensis Georgi suppress the AGE mediated inflammatory responses in the THP-1 cells. AGE treatment increased the gene expression of pro-inflammatory cytokines such as tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-$1{\beta}$ (IL-$1{\beta}$), monocyte chemotactic protein-1 (MCP-1) and cyclooxygenase-2 (COX-2). Reverse transcriptase-polymerase chain reaction and Western blot analysis revealed that S. baicalensis had inhibitory effects on the expression of pro-inflammatory genes and protein levels in AGE-treated THP-1 cells. S. baicalensis had also reduced the production of ROS in the AGE-treated THP-1 cells. These results suggest that S. baicalensis has inhibitory effects for the development of diabetic vascular complication.

Keywords

References

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