Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Rehmannia glutinosa on Phosphorylation of ERK and CREB in Acute Cocaine-treated Rats

건지황의 급성코카인 투여에 의한 ERK, CREB 인산화에 미치는 효과

  • Kwon, Ki-Won (Department of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Jang, Eun-Young (Department of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Im, Chae-Kwang (Department of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Yang, Chae-Ha (Department of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Kim, Kwang-Joong (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
  • 권기원 (대구한의대학교 한의과대학 생리학교실) ;
  • 장은영 (대구한의대학교 한의과대학 생리학교실) ;
  • 임채광 (대구한의대학교 한의과대학 생리학교실) ;
  • 양재하 (대구한의대학교 한의과대학 생리학교실) ;
  • 김광중 (대구한의대학교 한의과대학 생리학교실)
  • Received : 2012.05.08
  • Accepted : 2012.06.18
  • Published : 2012.06.25
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Abstract

The present study was designed to investigate the effect of Rehmannia glutinosa on phosphorylation of extracellular signal-regulated kinase(ERK) and cAMP response element-binding protein(CREB) in the acute cocaine-treated rats. Rats orally received vehicle or extract of Rehmannia glutinosa 1 h prior to saline (1 ml/kg, i.p.) or cocaine hydrochloride (20 mg/kg, i.p.) treatment. Rats were sacrificed 15 min after a single intraperitoneal injection of saline or cocaine. Rehmannia glutinosa at dose of 50 mg/kg significantly decreased phosphorylation of ERK, CREB and Elk-1 in the nucleus accumbens and striatum of the cocaine-treated rat brain by immunocytochemistry. These results suggest that Rehmannia glutinosa may contribute to the effects of cocaine on gene expression and on behaviors.

Keywords

References

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