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The Safety and Pharmacokinetics of Cyanidin-3-Glucoside after 2-Week Administration of Black Bean Seed Coat Extract in Healthy Subjects

  • Jeon, Sang-Il (Department of Pharmacology, College of Medicine, The Catholic University of Korea, Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary's Hospital) ;
  • Han, Seung-Hoon (Department of Pharmacology, College of Medicine, The Catholic University of Korea, Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary's Hospital) ;
  • Lee, Jong-Tae (Department of Pharmacology, College of Medicine, The Catholic University of Korea, Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary's Hospital) ;
  • Hong, Tae-Gon (Department of Pharmacology, College of Medicine, The Catholic University of Korea, Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary's Hospital) ;
  • Yim, Dong-Seok (Department of Pharmacology, College of Medicine, The Catholic University of Korea, Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary's Hospital)
  • Received : 2012.04.27
  • Accepted : 2012.06.12
  • Published : 2012.08.30

Abstract

We analyzed the pharmacokinetics of C3G on data from twelve subjects, after 2-week multiple dosing of black bean (Phaseolus vulgaris, Cheongjakong-3-ho) seed coat extract, using the mixed effect analysis method (NONMEM, Ver. 6.2), as well as the conventional non-compartmental method. We also examined the safety and tolerability. The PK analysis used plasma concentrations of the C3G on day 1 and 14. There was no observed accumulation of C3G after 2-week multiple dosing of black bean seed coat extract. The typical point estimates of PK were CL (clearance)=3,420 l/h, V (volume)=7,280 L, Ka (absorption constant)=9.94 $h^{-1}$, ALAG (lag time)=0.217 h. The black bean seed coat extract was well tolerated and there were no serious adverse events. In this study, we confirmed that a significant amount of C3G was absorbed in human after given the black bean seed coat extract.

Keywords

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