DOI QR코드

DOI QR Code

Characteristics of Mammary Paget's Disease in China: a National-wide Multicenter Retrospective Study During 1999-2008

  • Zheng, Shan (Department of Pathology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Song, Qing-Kun (Department of Cancer Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Zhao, Lin (Department of Breast Surgery, Liaoning Cancer Hospital) ;
  • Huang, Rong (Department of Cancer Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Sun, Li (Department of Breast Surgery, Liaoning Cancer Hospital) ;
  • Li, Jing (Department of Cancer Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Fan, Jin-Hu (Department of Cancer Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Zhang, Bao-Ning (Center of Breast Disease, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Yang, Hong-Jian (Department of Breast Surgery, Zhejiang Cancer Hospital) ;
  • Xu, Feng (Department of Breast-thyroid Surgery, Xiangya Second Hospital, Central South University) ;
  • Zhang, Bin (Department of Breast Surgery, Liaoning Cancer Hospital) ;
  • Qiao, You-Lin (Department of Cancer Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College)
  • 발행 : 2012.05.30

초록

The aim of this study was to detail characteristics of mammary Paget's disease (PD) representing the whole population in China. A total of 4211 female breast cancer inpatients at seven tertiary hospitals from seven representative geographical regions of China were collected randomly during 1999 to 2008. Data for demography, risk factors, diagnostic imaging test, physical examination and pathologic characters were surveyed and biomarker status was tested by immunohistochemistry. The differences of demography and risk factors between PD with breast cancer and other lesions were compared using Chi-square test or t-test, with attention to physical examination and pathological characters. The percentage of PD was 1.6% (68/4211) in all breast cancers. The mean age at diagnosis was 48.1, and 63.2% (43/68) patients were premenopausal. There is no difference in demography and risk factors between PD with breast cancer and other breast cancer (P > 0.05). The main pattern of PD in physical exam and pathologic pattern were patients presenting with a palpable mass in breast (65/68, 95.6%) and PD with underlying invasive cancer (82.4%, 56/68) respectively. The rate of multifocal disease was 7.4% (5/68). PD with invasive breast cancer showed larger tumor size, more multifocal disease, lower ER and PR expression and higher HER2 overexpression than those in other invasive breast cancer (P < 0.05). These results suggested that PD in China is a concomitant disease of breast cancer, and that PD with underlying invasive cancer has more multiple foci and more aggressive behavior compared with other breast invasive cancer. We address the urgent needs for establishing diagnostic and therapeutic guidelines for mammary PD in China.

키워드

참고문헌

  1. Adachi Y, Kakisako K, Sato K, Shiraishi N, Kitano S (1998). Paget's disease of the breast: report of five cases and review of the Japanese literature. Breast Cancer, 5, 195-200. https://doi.org/10.1007/BF02966695
  2. Al-Abbadi MA, Washington TA, Saleh HA, et al (2006). Differential expression of HER-2/NEU receptor of invasive mammary carcinoma between Caucasian and African American patients in the Detroit metropolitan area, Correlation with overall survival and other prognostic factors. Breast Cancer Res Treat, 97, 3-8. https://doi.org/10.1007/s10549-005-5149-z
  3. American Joint Committee on Cancer (1997). AJCC Cancer staging Manual, 5th eds. Philadelphia: Lippincott-Raven, 171-80.
  4. American Joint Committee on Cancer (2002) AJCC Cancer staging Manual, 6th eds. New York: Springer, 223-40.
  5. Ascenso AC, Marques MS, Capitao-Mor M (1985). Paget's disease of the nipple. Clinical and pathological review of 109 female patients. Dermatologica, 170, 170-9. https://doi.org/10.1159/000249526
  6. Ashikari R, Park K, Huvos AG, Urban JA (1970). Paget's disease of the breast. Cancer, 26, 680-5. https://doi.org/10.1002/1097-0142(197009)26:3<680::AID-CNCR2820260329>3.0.CO;2-P
  7. Bao PP, Shu XO, Gao YT, et al (2011). Association of hormonerelated characteristics and breast cancer risk by estrogen receptor/progesterone receptor status in the shanghai breast cancer study. Am J Epidemiol, 174, 661-71. https://doi.org/10.1093/aje/kwr145
  8. Caliskan M, Gatti G, Sosnovskikh I, et al (2008). Paget's disease of the breast: the experience of the European Institute of Oncology and review of the literature. Breast Cancer Res Treat, 112 513-21. https://doi.org/10.1007/s10549-007-9880-5
  9. Chaudary MA, Millis RR, Lane EB, Miller NA (1986). Paget's disease of the nipple: a ten year review including clinical, pathological, and immunohistochemical findings. Breast Cancer Res Treat, 8, 139-46. https://doi.org/10.1007/BF01807702
  10. Chen CY, Sun LM, Anderson BO (2006). Paget disease of the breast: changing patterns of incidence, clinical presentation, and treatment in the U.S. Cancer, 107, 1448-58. https://doi.org/10.1002/cncr.22137
  11. Chen XY, Kong ZL (2010). Chinese Cancer Registry Annual Report 2009, 1st eds. Beijing: Military Medical Science Press, 26-37. [Chinese]
  12. Dalberg K, Hellborg H, Wärnberg F (2008). Paget's disease of the nipple in a population based cohort. Breast Cancer Res Treat, 111, 313-9. https://doi.org/10.1007/s10549-007-9783-5
  13. Di GH, Wu J, Yu KD, Lu JS, Shen KW, et al (2007). [Surgical management of early breast cancer]. Zhonghua Zhong Liu Za Zhi, 29, 62-5 [Chinese].
  14. Ding SL, Yu JC, Chen ST, et al (2010). Diverse associations between ESR1 polymorphism and breast cancer development and progression. Clin Cancer Res, 16, 3473-84. https://doi.org/10.1158/1078-0432.CCR-09-3092
  15. Fu W, Mittel VK, Young SC (2001). Paget disease of the breast: analysis of 41 patients. Am J Clin Oncol, 24, 397-400. https://doi.org/10.1097/00000421-200108000-00019
  16. Hanna W, Alowami S, Malik A (2003). The role of HER-2/neu oncogene and vimentin filaments in the production of the Paget's phenotype. Breast J, 9, 485-90. https://doi.org/10.1046/j.1524-4741.2003.09610.x
  17. Hu Z, Wu J, Liu CH, et al (2003). The analysis of BRCA1 mutations in eastern Chinese patients with early onset breast cancer and affected relatives. Hum Mutat, 22, 104.
  18. Kawase K, Dimaio DJ, Tucker SL, et al (2005). Paget's disease of the breast: there is a role for breast-conserving therapy. Ann Surg Oncol 2005, 12, 391-7. https://doi.org/10.1245/ASO.2005.05.026
  19. Kollmorgen DR, Varanasi JS, Edge SB, Carson WE (1998). Paget's disease of the breast: a 33-year experience. J Am Coll Surg, 187, 171-7. https://doi.org/10.1016/S1072-7515(98)00143-4
  20. Kothari AS, Beechey-Newman N, Hamed H, et al (2002). Paget disease of the nipple: a multifocal manifestation of higherrisk disease. Cancer, 95, 1-7. https://doi.org/10.1002/cncr.10638
  21. Lagios MD, Westdahl PR, Rose MR, Concannon S (1984). Paget's disease of the nipple, Alternative management in cases without or with minimal extent of underlying breast carcinoma. Cancer, 54, 545-51. https://doi.org/10.1002/1097-0142(19840801)54:3<545::AID-CNCR2820540327>3.0.CO;2-M
  22. Li J, Zhang BN, Fan JH, Pang Y, et al (2011). A nation-wide multicenter 10-year (1999-2008) retrospective clinical epidemiological study of female breast cancer in China. BMC Cancer, 22, 364.
  23. Liu N, Wang C, Shao Y (2000). Breast cancer accompanied by Paget's disease: an analysis of 34 cases. Zhonghua Zhong Liu Za Zhi, 22, 64-6 (in Chinese).
  24. Mai KT, Yazdi HM, Perkins DG (1999). Mammary Paget's disease: evidence of diverse origin of the disease with a subgroup of Paget's disease developing from the superficial portion of lactiferous duct and a discontinuous pattern of tumor spread. Pathol Int, 49, 956-61. https://doi.org/10.1046/j.1440-1827.1999.00976.x
  25. Meibodi NT, Ghoyunlu VM, Javidi Z, Nahidi Y (2008). Clinicopathologic evaluation of mammary Paget's disease. Indian J Dermatol, 53, 21-3. https://doi.org/10.4103/0019-5154.39736
  26. Nance FC, DeLoach DH, Welsh RA, Becker WF (1970). Paget's disease of the breast. Ann Surg, 171, 864-74. https://doi.org/10.1097/00000658-197006010-00007
  27. National Office for (NOCPC) of the Chinese Ministry of Health Cancer Prevention and Control (2010). National Survey on Cancer Mortality in China-The Third Sample Survey on Mortality, first eds. Beijing: The People's Health Press, 10-22 [Chinese].
  28. Onoe S, Kinoshita T, Tamura N, et al (2011). Feasibility of breast conserving surgery for Paget's disease. Breast, 20, 515-8. https://doi.org/10.1016/j.breast.2011.05.010
  29. Paget J (1874). On disease of the mammary areola preceding cancer of the mammary gland. St Bartholomew Hosp Rep, 10, 87-9.
  30. Paone JF, Baker RR (1981). Pathogenesis and treatment of Paget's disease of the breast. Cancer, 48, 825-9. https://doi.org/10.1002/1097-0142(19810801)48:3<825::AID-CNCR2820480326>3.0.CO;2-#
  31. Sakorafas GH, Blanchard K, Sarr MG, Farley DR (2001). Paget's disease of the breast. Cancer Treat Rev, 27, 9-18. https://doi.org/10.1053/ctrv.2000.0203
  32. Shyyan R, Sener SF, Anderson BO, et al (2008). Guideline implementation for breast healthcare in low- and middleincome countries: diagnosis resource allocation. Cancer, 113, 2257-68. https://doi.org/10.1002/cncr.23840
  33. Sukumvanich P, Bentrem DJ, Cody HS, et al (2007). The role of sentinel lymph node biopsy in Paget's disease of the breast. Ann Surg Oncol, 14, 1020-3. https://doi.org/10.1245/s10434-006-9056-2
  34. Sun Q, Zhou YD, Huang HY (2003). Diagnosis and treatment of Paget's disease of the breast: report of 33 cases. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 25, 93-5 (in Chinese).
  35. Tavassoli FA, Devilee P (2003). Pathology and Genetics of Tumours of the Breast and Female Genital Organs, 1st eds. Lyon: IARC, 2003, 221-32.
  36. Toi M, Ohashi Y, Seow A, Moriya T, et al (2010). The Breast Cancer Working Group presentation was divided into three sections: the epidemiology, pathology and treatment of breast cancer. Jpn J Clin Oncol, 40, i13-i18. https://doi.org/10.1093/jjco/hyq122
  37. Wang C, Zhao P, Bai X, Wang H, Bai Y (2002). [Breast cancer in multiple primary malignant neoplasms, epidemiological and clinical analysis]. Zhonghua Yi Xue Za Zhi, 82, 1229-31 [Chinese].
  38. WHO (1981). Histological typing of breast tumors, 2nd ed. Geneva: WHO, 1981:. 806.
  39. Yim JH, Wick MR, Philpott GW, Norton JA, Doherty GM (1997). Underlying pathology in mammary Paget's disease. Ann Surg Oncol, 4, 287-92. https://doi.org/10.1007/BF02303576
  40. Yu XM, Wang WD, Zhang CH, Huang SF (2005). Cytopathological scrape examination of superficial lesions of skin and mucosal membrane--a cytological and histological comparative study of 148 cases. Zhonghua Bing Li Xue Za Zhi, 34, 637-40 (in Chinese).
  41. Zakaria S, Pantvaidya G, Ghosh K, Degnim AC (2007). Paget's disease of the breast: accuracy of preoperative assessment. Breast Cancer Res Treat, 102, 137-42. https://doi.org/10.1007/s10549-006-9329-2
  42. Zarbo RJ, Hammond ME (2003). Conference summary, Strategic Science symposium. Her-2/neu testing of breast cancer patients in clinical practice. Arch Pathol Lab Med, 127, 549-53.
  43. Zheng S, Bai JQ, Li J, et al (2012). The pathologic characteristics of breast cancer in China and its shift during 1999-2008: A national-wide multicenter cross-sectional image over 10 years. Int J Cancer, doi: 10.1002/ijc.27513 [in press].

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