참고문헌
- Andersen JN, Sathyanarayanan S, Di Bacco A, et al. (2010). Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors. Sci Transl Med, 2, 43-55.
- Baryawno N, Sveinbjornsson B, Eksborg S, et al. (2010). Smallmolecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth. Cancer Res, 70, 266-76. https://doi.org/10.1158/0008-5472.CAN-09-0578
- Ching CB, Hansel DE (2010). Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway. Lab Invest, 90, 1406-14. https://doi.org/10.1038/labinvest.2010.133
- Choi JH, Yang YR, Lee SK, et al (2008). Potential inhibition of PDK1/Akt signaling by phenothiazines suppresses cancer cell proliferation and survival. Ann N Y Acad Sci, 1138, 393-403. https://doi.org/10.1196/annals.1414.041
- Cully M, You H, Levine AJ, Mak TW (2006). Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer, 6, 184-92. https://doi.org/10.1038/nrc1819
- De Santis M, Bellmunt J, Mead G, et al (2009). Randomized phase II/III trial assessing gemcitabine/ carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer "unfit" for cisplatin-based chemotherapy: phase II--results of EORTC study 30986. J Clin Oncol, 27, 5634-9 https://doi.org/10.1200/JCO.2008.21.4924
- Duronio V (2008). The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem J, 415, 333-44. https://doi.org/10.1042/BJ20081056
- Fan QW, Knight ZA, Goldenberg DD, et al (2006). A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell, 9, 341-9. https://doi.org/10.1016/j.ccr.2006.03.029
- Feldman RI, Wu JM, Polokoff MA, et al (2005). Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem, 280, 19867-74. https://doi.org/10.1074/jbc.M501367200
- Franken NA, Rodermond HM, Stap J, et al. (2006). Clonogenic assay of cells in vitro. Nat Protoc, 1, 2315-9. https://doi.org/10.1038/nprot.2006.339
- Gupta AK, Cerniglia GJ, Mick R, et al (2003). Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002. Int J Radiat Oncol Biol Phys, 56, 846-53. https://doi.org/10.1016/S0360-3016(03)00214-1
- Hansel DE, Platt E, Orloff M, et al (2010). Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma. Am J Pathol, 176, 3062-72. https://doi.org/10.2353/ajpath.2010.090872
- Ikeda M, Matsumoto K, Niibe Y, et al (2011). The radiotherapy with methotrexate, vinblastine, doxorubicin, and cisplatin treatment is an effective therapeutic option in patients with advanced or metastatic bladder cancer. J Radiat Res, 52, 674-9. https://doi.org/10.1269/jrr.11036
- Ishikawa Y, Tachibana M, Matsui C, et al (2009). Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-kappaB. Bioorg Med Chem Lett, 19, 1726-8. https://doi.org/10.1016/j.bmcl.2009.01.107
- Ismaili N, Amzerin M, Flechon A (2011). Chemotherapy in advanced bladder cancer: current status and future. J Hematol Oncol, 4, 35. https://doi.org/10.1186/1756-8722-4-35
- Ito A, Kaneda A, Takeiri M, Umezawa K (2011). Indcution of apoptosis in adult T-cell leucemia by the novel PDK1 inhibitor DTCM-glutarimide. Int J Molecular Med, 28, 11.
- Jemal A, Siegel R, Ward E, et al (2008). Cancer statistics, 2008. CA Cancer J Clin, 58, 71-96. https://doi.org/10.3322/CA.2007.0010
- Kaufman DS (2006). Challenges in the treatment of bladder cancer. Ann Oncol, 17, 106-12. https://doi.org/10.1093/annonc/mdj963
- Kim IA, Bae SS, Fernandes A, et al (2005). Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer Res, 65, 7902-10. https://doi.org/10.1158/0008-5472.CAN-05-0513
- Klionsky DJ, Abeliovich H, Agostinis P, et al (2008). Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 4, 151-75. https://doi.org/10.4161/auto.5338
- Lee YJ, Shacter E (1999). Oxidative stress inhibits apoptosis in human lymphoma cells. J Biol Chem, 274, 19792-8. https://doi.org/10.1074/jbc.274.28.19792
- Liang CC, Park AY, Guan JL (2007). In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc, 2, 329-33. https://doi.org/10.1038/nprot.2007.30
- Liu Y, Wang J, Wu M, et al (2009). Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. Mol Cancer Res, 7, 944-54. https://doi.org/10.1158/1541-7786.MCR-08-0368
- Marta GN, Hanna SA, Gadia R, et al (2012). The role of radiotherapy in urinary bladder cancer: current status. Int Braz J Urol, 38, 144-54. https://doi.org/10.1590/S1677-55382012000200002
- Pauwels B, Korst AE, de Pooter CM, et al (2003). Comparison of the sulforhodamine B assay and the clonogenic assay for in vitro chemoradiation studies. Cancer Chemother Pharmacol, 51, 221-6.
- Peifer C, Alessi DR. (2009) New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen. Biochem J, 417, 5-7. https://doi.org/10.1042/BJ20082243
- Qian Y, Deng J, Xie H, et al (2009). Regulation of TLR4-induced IL-6 response in bladder cancer cells by opposing actions of MAPK and PI3K signaling. J Cancer Res Clin Oncol, 135, 379-86. https://doi.org/10.1007/s00432-008-0478-z
- Rieger-Christ KM, Lee P, Zagha R, et al (2004). Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway. Oncogene, 23, 4745-53. https://doi.org/10.1038/sj.onc.1207629
- Sargeant AM, Klein RD, Rengel RC, et al (2007). Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer. Toxicol Pathol, 35, 549-61. https://doi.org/10.1080/01926230701338966
- Sato S, Fujita N, Tsuruo T (2002). Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). Oncogene, 21, 1727-38. https://doi.org/10.1038/sj.onc.1205225
- Segerstrom L, Baryawno N, Sveinbjornsson B, et al (2011). Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo. Int J Cancer, 129, 2958-65 https://doi.org/10.1002/ijc.26268
- Sellers WR, Fisher DE (1999). Apoptosis and cancer drug targeting. J Clin Invest, 104, 1655-61. https://doi.org/10.1172/JCI9053
- Sun CH, Chang YH, Pan CC (2011). Activation of the PI3K/ Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder. Histopathology, 58, 1054-63. https://doi.org/10.1111/j.1365-2559.2011.03856.x
- Takeiri M, Tachibana M, Kaneda A, et al (2011). Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone. Inflamm Res, 60, 879-88. https://doi.org/10.1007/s00011-011-0348-z
- Tao Y, Zhang P, Frascogna V, et al (2007). Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells. Br J Cancer, 97, 1664-72. https://doi.org/10.1038/sj.bjc.6604083
- Wang, Z. Igarashi, M. Ikeda, et al (2006). Inhibition of NF kappa B activation by 9-methylstreptimidone isolated from Streptomyces. Heterocycles, 69, 377-383. https://doi.org/10.3987/COM-06-S(O)47
- Wu X, Obata T, Khan Q, Highshaw RA, et al (2004). The phosphatidylinositol-3 kinase pathway regulates bladder cancer cell invasion. BJU Int, 93, 143-50. https://doi.org/10.1111/j.1464-410X.2004.04574.x
피인용 문헌
- CISD2 promotes the proliferation of glioma cells via suppressing beclin-1-mediated autophagy and is targeted by microRNA-449a vol.16, pp.6, 2017, https://doi.org/10.3892/mmr.2017.7642