Asian Pacific Journal of Cancer Prevention

  • 제13권5호
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  • Pages.1995-1997
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Brain Metastases from Cholangiocarcinoma: a First Case Series in Thailand

  • Chindaprasirt, Jarin (Medical Oncology Division, Department of Medicine, Facult of Medicine, Khon Kaen University) ;
  • Sookprasert, Aumkhae (Medical Oncology Division, Department of Medicine, Facult of Medicine, Khon Kaen University) ;
  • Sawanyawisuth, Kittisak (Ambulatory Medicine Division, Department of Medicine, Facult of Medicine, Khon Kaen University) ;
  • Limpawattana, Panita (Ambulatory Medicine Division, Department of Medicine, Facult of Medicine, Khon Kaen University) ;
  • Tiamkao, Somsak (Neurology Division, Department of Medicine, Facult of Medicine, Khon Kaen University)
  • 발행 : 2012.05.30
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초록

Background: Brain metastasis from cholangiocarcinoma (CCA) is a rare but fatal event. To the best of our knowledge, only few cases have been reported. Herein, we report the incident rate and a first case series of brain metastases from CCA. Methods: Between January 2006 and December 2010 5,164 patients were treated at Srinagarind hospital, Khon Kaen University; of those, 8 patients developed brain metastasis. Here we reviewed clinical data and survival times. Results: The incident rate of brain metastases from CCA was 0.15%. The median age of the patients was 60 years. Tumor subtypes were intrahepatic in 6 and hilar in 2 patients. All suffered from symptoms related to brain metastasis. Three patients were treated with whole-brain radiation therapy (WBRT), one of whom also underwent surgery. The median survival after the diagnosis of brain metastasis was 9.5 weeks (1-28 weeks). The longest survival observed in a patient in RPA class I with two brain lesions and received WBRT. Conclusion: This is a first case series of brain metastases from CCA with the incident rate of 0.15%. It is rare and associated with short survival time.

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참고문헌

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