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Loss of DBC2 Expression is an Early and Progressive Event in the Development of Lung Adenocarcinoma

  • Dong, Wei (Institute of Oncology, Provincial Hospital affiliated to Shandong University, Shandong University) ;
  • Meng, Long (Department of Thoracic Surgery, Provincial Hospital affiliated to Shandong University, Shandong University) ;
  • Shen, Hong-Chang (Institute of Oncology, Provincial Hospital affiliated to Shandong University, Shandong University) ;
  • Du, Jia-Jun (Institute of Oncology, Provincial Hospital affiliated to Shandong University, Shandong University)
  • 발행 : 2012.05.30

초록

Purpose: DBC2 (Deleted in Breast Cancer 2) has been indicated to be a tumor suppressor gene in many cancers including lung adenocarcinoma recently. In this study, we aimed to explore the expression status of DBC2 in different subtypes of lung adenocarcinoma (from pre-invasive to invasive lesions), and to determine if downregulation becomes more marked with pathological progression. Methods: We collected 172 tissue samples from different subtypes of lung adenocarcinoma and investigated the frequency of DBC2 loss by immunohistochemistry. Results: Our results indicated that DBC2 downregulation is a relatively frequent event in lung adenocarcinoma. Moreover, as the adenocarcinoma subtype turns to be more invasive, more downregulation occurred. Conclusion: We conclude that loss of DBC2 expression is an early and progressive event in the pathogenesis of lung adenocarcinoma. Positive DBC2 immunohistochemistry may become an indicator for early stage disease and better prognosis of lung adenocarcinomas.

키워드

참고문헌

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피인용 문헌

  1. Hsp90-Dependent Assembly of the DBC2/RhoBTB2-Cullin3 E3-Ligase Complex vol.9, pp.3, 2014, https://doi.org/10.1371/journal.pone.0090054
  2. Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis vol.5, pp.2, 2016, https://doi.org/10.3390/cells5020028
  3. DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer vol.36, pp.20, 2017, https://doi.org/10.1038/onc.2016.441