Asian Pacific Journal of Cancer Prevention

  • 제13권5호
  • /
  • Pages.2335-2338
  • /
  • 2012
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Metabolic Changes Enhance the Cardiovascular Risk with Differentiated Thyroid Carcinoma - A Case Control Study from Manipal Teaching Hospital of Nepal

  • Mittal, Ankush (Department of Biochemistry, Nepalese Army Institute of Health Sciences, Manipal College of Medical Sciences) ;
  • Poudel, Bibek (Department of Biochemistry, Nepalese Army Institute of Health Sciences, Manipal College of Medical Sciences) ;
  • Pandeya, Dipendra Raj (Department of Biochemistry, Nepalese Army Institute of Health Sciences, Manipal College of Medical Sciences) ;
  • Gupta, Satrudhan Pd (Department of Biochemistry, Nepalese Army Institute of Health Sciences, Manipal College of Medical Sciences) ;
  • Sathian, Brijesh (Department of Community Medicine, Nepalese Army Institute of Health Sciences, Manipal College of Medical Sciences) ;
  • Yadav, Shambhu Kumar (Department of Biochemistry, Nepalese Army Institute of Health Sciences, Manipal College of Medical Sciences)
  • 발행 : 2012.05.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: To evaluate several metabolic changes in patients with differentiated thyroid carcinoma (DTC ) which enhance cardiovascular risk in the western region of Nepal. Materials and Methods: This hospital based case control study was carried out using data retrieved from the register maintained in the Department of Biochemistry of the Manipal Teaching Hospital, Pokhara, Nepal between $1^{st}$ January, 2009 and $31^{st}$ December, 2011. The variables collected were age, gender, BMI, glucose, insulin, HbA1C, CRP, fibrinogen, total cholesterol, triglycerides, HDL, LDL, VLDL, f-T3, f-T4, TSH. One way ANOVA was used to examine statistical significance of differences between groups, along with the Post Hoc test LSD for comparison of means. Results: fT3 values were markedly raised in DTC cases ($5.7{\pm}SD1.4$) when compared to controls ($2.2{\pm}SD0.9$). Similarly, fT4 values were also moderately raised in cases of DTC ($4.9{\pm}SD1.3$ and $1.7{\pm}SD0.9$). In contrast, TSH values were lowered in DTC cases ($0.39{\pm}SD0.4$) when compared to controls ($4.2{\pm}SD1.4$). Mean blood glucose levels were decreased while insulin was increased and HDL reduced ($39.5{\pm}SD4.7$ as compared to the control $43.1{\pm}SD2.2$). Conclusion: Cardiovascular risk may be aggravated by insulin resistance, a hypercoagulable state, and an atherogenic lipid profile in patients with differentiated thyroid cancer.

키워드

참고문헌

  1. Abrams JJ, Grundy SM (1981). Cholesterol metabolism in hypothyroidism and hyperthyroidism in man. J Lipid Res, 22, 323-38.
  2. Akbari ME, Rafiee M, Khoei MA, et al (2011). Incidence and survival of cancers in the elderly population in Iran: 2001-2005. APJCP, 12, 3035-9.
  3. Bauer DC, Rodondi N, Stone KL, et al (2007). Thyroid hormone use, hyperthyroidism and mortality in older women. Am J Med, 120, 343-9. https://doi.org/10.1016/j.amjmed.2006.04.034
  4. Binu VS, Chandrashekhar TS, Subba SH, et al (2007). Cancer pattern in Western Nepal: a hospital based retrospective study. APJCP, 8, 183-6.
  5. Di Giovambattista R (2008). Hyperthyroidism as a reversible cause of right ventricular overload and congestive heart failure. Cardiovasc Ultrasound, 6, 29. https://doi.org/10.1186/1476-7120-6-29
  6. Giusti M, Mortara L, Degrandi R, et al (2008). Metabolic and cardiovascular risk in patients with a history of differentiated thyroid carcinoma: A case-controlled cohort study. Thyroid Res, 1, 2. https://doi.org/10.1186/1756-6614-1-2
  7. Kebebew E, Clark OH (2000). Differentiated thyroid cancer: "complete"rational approach. World J Surg, 24, 942-51. https://doi.org/10.1007/s002680010165
  8. Kirkegaard C, Friis T, Siersbaek-Nielsen K (1974). Measurements of serum triiodothyronine by radioimmunoassay. Acta Endocrinol, 77, 71-81.
  9. Monson JP (2007). The epidemiology of endocrine tumours. Endocr Relat Cancer, 7, 29-36.
  10. Moore MA, Ariyaratne Y, Badar F, et al (2010).Cancer epidemiology in South Asia - past, present and future. Asian Pacific J Cancer Prev, 11, 49-66.
  11. Moshides S (1987). Kinetic Enzymatic Method for Automated Determination of HDL Cholesterol in Plasma. J Clin Chem Clin Biochem, 25 , 583-7.
  12. Rossing MA, Voigt LF, Wicklund KG, et al (2000). Reproductive factors and risk of papillary thyroid cancer in women. AmJ Epidemiol, 151, 765-72. https://doi.org/10.1093/oxfordjournals.aje.a010276
  13. Trinder P (1969). Determination of serum cholesterol by enzymatic colorimetric method. Ann ClinBiochem, 6, 24-7.
  14. V Vella, L Sciacca, G Pandini, et al (2001). The IGF system in thyroid cancer: new concepts. Mol Pathol, 54, 121-4. https://doi.org/10.1136/mp.54.3.121
  15. Warnick GR, Knopp RH, Fitzpatrick V, et al (1990). Estimating low-density lipoprotein cholesterol by the Friedewald equation is adequate for classifying patients on the basis of nationally recommended cutpoints. ClinChem, 36, 15-9.
  16. Yang Y, Li Q, Guo L et al (2011). A retrospective analysis of thyroid cancer in China. Asian Pacific J Cancer Prev, 12, 2245-9.
  17. Yao Z, Yin P, Su D, et al (2011). Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter. Mol Biosyst, 7, 2608-14. https://doi.org/10.1039/c1mb05029j

피인용 문헌

  1. Relationship between Breast Cancer and Levels of Serum Thyroid Hormones and Antibodies: a Meta-analysis vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6643