Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Drynariae Rhizoma in RANKL-induced Osteoclast Differentiation

골쇄보가 RANKL에 의해 유도되는 파골세포의 분화에 미치는 영향

  • Kwak, Seong-Cheoul (Department of Anatomy, School of Medicine, Wonkwang University & Institute for Skeletal Disease and Wonkwang Medical Science Institute) ;
  • Moon, Seo-Young (Division of Anesthesiology and Pain Medicine, Sanbon Medical Center) ;
  • Kwack, Han-Bok (Department of Anatomy, School of Medicine, Wonkwang University & Institute for Skeletal Disease and Wonkwang Medical Science Institute) ;
  • Jeon, Byung-Hun (Department of Pathology, College of Korean Medicine & Research Center of Traditional Korean Medicine, Wonkwang University) ;
  • Min, Oh-Jae (Department of Anatomy, School of Medicine, Wonkwang University & Institute for Skeletal Disease and Wonkwang Medical Science Institute) ;
  • Choi, Min-Kyu (Department of Anatomy, School of Medicine, Wonkwang University & Institute for Skeletal Disease and Institute for Environmental Science) ;
  • Kim, Jeong-Joong (Department of Anatomy, School of Medicine, Wonkwang University & Institute for Skeletal Disease and Wonkwang Medical Science Institute) ;
  • Jang, Sung-Jo (Department of Neurosurgery, Gunsan Medical Center)
  • 곽성철 (원광대학교 의과대학 해부학교실 & 골격계 질환 연구소 및 의과학연구소) ;
  • 문서영 (산본병원 마취통증의학과) ;
  • 곽한복 (원광대학교 의과대학 해부학교실 & 골격계 질환 연구소 및 의과학연구소) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실 & 한국전통의학연구소) ;
  • 오재민 (원광대학교 의과대학 해부학교실 & 골격계 질환 연구소 및 의과학연구소) ;
  • 최민규 (원광대학교 의과대학 해부학교실 & 골격계 질환 연구소 및 환경과학연구소) ;
  • 김정중 (원광대학교 의과대학 해부학교실 & 골격계 질환 연구소 및 의과학연구소) ;
  • 장성조 (군산의료원 신경외과)
  • Received : 2012.07.24
  • Accepted : 2012.08.10
  • Published : 2012.08.25
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Abstract

Bone homeostasis is regulated by the balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoporosis, rheumatoid arthritis and periodontal disease are related with up-regulated osteoclast formation and its activity. Gol-Swae-Bo(Drynariae Rhizoma) is widely used on skeletal disease. In this study, we sought to examine the effect of Drynariae Rhizoma in RANKL-induced osteoclast differentiation. The extract of Drynariae Rhizoma inhibited RANKL-induced osteoclast differentiation in a dose dependent manner without cytotoxicity. receptor activator of nuclear factor-${\kappa}B$ ligand(RANKL) mediated $I{\kappa}B$ degradation in bone marrow macrophages(BMMs). However, the extract of Drynariae Rhizoma inhibited RANKL induced $I{\kappa}B$ degradation in BMMs. And mRNA expression of OSCAR, TRAP, c-Fos and NFATc1 was suppressed by the extract of Drynariae Rhizoma. Moreover, the extract of Drynariae Rhizoma inhibited the protein expression of NFATc1 and c-Fos induced by RANKL. After all the analysis, these results suggest that Drynariae Rhizoma may be good candidate of medicine in the treatment of bone-related disease.

Keywords

References

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