Asian Pacific Journal of Cancer Prevention

  • 제14권10호
  • /
  • Pages.6025-6030
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  • 2013
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Matrix Metalloproteinase-2 (-1306 C>T) Promoter Polymorphism and Risk of Colorectal Cancer in the Saudi Population

  • Saeed, Hesham Mahmoud (Biochemistry Department, Division of Gastroenterology, Faculty of Medicine, King Khalid University Hospital) ;
  • Alanazi, Mohammad Saud (Biochemistry Department, Division of Gastroenterology, Faculty of Medicine, King Khalid University Hospital) ;
  • Parine, Narasimha Reddy (Biochemistry Department, Division of Gastroenterology, Faculty of Medicine, King Khalid University Hospital) ;
  • Shaik, Jilani (Biochemistry Department, Division of Gastroenterology, Faculty of Medicine, King Khalid University Hospital) ;
  • Semlali, Abdelhabib (Biochemistry Department, Division of Gastroenterology, Faculty of Medicine, King Khalid University Hospital) ;
  • Alharbi, Othman (Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, King Khalid University Hospital) ;
  • Azzam, Nahla (Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, King Khalid University Hospital) ;
  • Aljebreen, Abdulrahman (Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, King Khalid University Hospital) ;
  • Almadi, Majid (Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, King Khalid University Hospital) ;
  • Shalaby, Manal Aly (Biochemistry Department, Division of Gastroenterology, Faculty of Medicine, King Khalid University Hospital)
  • 발행 : 2013.10.30
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초록

Background: Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), results in strikingly lower promoter activity with the T allele. In the present study, we investigated whether this MMP-2 genetic polymorphism might be associated with susceptibility to colorectal cancer (CRC) in the Saudi population. We also analyzed MMP-2 gene expression level sin CRC patients and 4 different cancer cell lines. Materials and Methods: TaqMan allele discrimination assays and DNA sequencing techniques were used to investigate the $C^{-1306}T$ SNP in the MMP-2 gene of Saudi colorectal cancer patients and controls. The MMP-2 gene expression level was also determined in 12 colon cancer tissue samples collected from unrelated patients and histologically normal tissues distant from tumor margins. Results and Conclusions: The MMP-2 $C^{-1306}T$ SNP in the promoter region was associated with CRC in our Saudi population and the MMP-2 gene expression level was found to be 10 times higher in CRC patients. The MMP-2 $C^{-1306}T$ SNP is significantly associated with CRC in the Saudi population and this finding suggested that MMP-2 variants might help predict CRC progression risk among Saudis. We propose that analysis of this gene polymorphism could assist in identification of patient subgroups at risk of a poor disease outcome.

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