Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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The DNA Repair Gene ERCC6 rs1917799 Polymorphism is Associated with Gastric Cancer Risk in Chinese

  • Liu, Jing-Wei (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department) ;
  • He, Cai-Yun (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department) ;
  • Sun, Li-Ping (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department) ;
  • Xu, Qian (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department) ;
  • Xing, Cheng-Zhong (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department) ;
  • Yuan, Yuan (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department)
  • Published : 2013.10.30
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Abstract

Objective: Excision repair cross-complementing group 6 (ERCC6) is a major component of the nucleotide excision repair pathway that plays an important role in maintaining genomic stability and integrity. Several recent studies suggested a link of ERCC6 polymorphisms with susceptibility to various cancers. However, the relation of ERCC6 polymorphism with gastric cancer (GC) risk remains elusive. In this sex- and age-matched case-control study including 402 GC cases and 804 cancer-free controls, we aimed to investigate the association between a potentially functional polymorphism (rs1917799 T>G) in the ERCC6 regulatory region and GC risk. Methods: The genotypes of rs1917799 were determined by Sequenom MassARRAY platform and the status of Helicobacter pylori infection was detected by enzyme-linked immunosorbent assay. Odd ratios (ORs) and 95% confidential interval (CI) were calculated by logistic regression analysis. Results: Compared with the common TT genotype, the ERCC6 rs1917799 GG genotype was associated with increased GC risk (adjusted OR=1.46, 95%CI: 1.03-2.08, P=0.035). When compared with (GT+TT) genotypes, the GG genotype also demonstrated a statistical association with increased GC risk (adjusted OR=1.38, 95%CI: 1.01-1.89, P=0.044). This was also observed for the male subpopulation (GG vs. TT: adjusted OR=1.71, 95%CI: 1.12-2.62, P=0.013; G allele vs. T allele: adjusted OR=1.32, 95%CI: 1.07-1.62, P=0.009). Genetic effects on increased GC risk tended to be enhanced by H. pylori infection, smoking and drinking, but their interaction effects on GC risk did not reach statistical significance. Conclusions: ERCC6 rs1917799 GG genotype might be associated with increased GC risk in Chinese, especially in males.

Keywords

References

  1. Berndt SI, Platz EA, Fallin MD, et al (2006). Genetic variation in the nucleotide excision repair pathway and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev, 15, 2263-9. https://doi.org/10.1158/1055-9965.EPI-06-0449
  2. Berwick M, Vineis P (2000). Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review. J Natl Cancer Inst, 92, 874-97. https://doi.org/10.1093/jnci/92.11.874
  3. Boraz RA (1991). Cockayne's syndrome: literature review and case report. Pediatr Dent, 13, 227-30.
  4. Brenner H, Rothenbacher D, Arndt V (2009). Epidemiology of stomach cancer. Methods Mol Biol, 472, 467-77. https://doi.org/10.1007/978-1-60327-492-0_23
  5. Chang CH, Chiu CF, Wang HC, et al (2009). Significant association of ERCC6 single nucleotide polymorphisms with bladder cancer susceptibility in Taiwan. Anticancer Res, 29, 5121-4.
  6. Chen M, Kamat AM, Huang M, et al (2007). High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk. Carcinogenesis, 28, 2160-5. https://doi.org/10.1093/carcin/bgm167
  7. Chiu CF, Tsai MH, Tseng HC, et al (2008). A novel single nucleotide polymorphism in ERCC6 gene is associated with oral cancer susceptibility in Taiwanese patients. Oral Oncol, 44, 582-6. https://doi.org/10.1016/j.oraloncology.2007.07.006
  8. Compare D, Rocco A, Nardone G (2010). Risk factors in gastric cancer. Eur Rev Med Pharmacol Sci, 14, 302-8.
  9. Correa P (2013). Gastric cancer: overview. Gastroenterol Clin North Am, 42, 211-7. https://doi.org/10.1016/j.gtc.2013.01.002
  10. Costa RM, Chigancas V, Galhardo Rda S, et al (2003). The eukaryotic nucleotide excision repair pathway. Biochimie, 85, 1083-99. https://doi.org/10.1016/j.biochi.2003.10.017
  11. de Laat WL, Jaspers NG, Hoeijmakers JH (1999). Molecular mechanism of nucleotide excision repair. Genes Dev, 13, 768-85. https://doi.org/10.1101/gad.13.7.768
  12. Farinati F, Cardin R, Cassaro M, et al (2008). Helicobacter pylori, inflammation, oxidative damage and gastric cancer: a morphological, biological and molecular pathway. Eur J Cancer Prev, 17, 195-200. https://doi.org/10.1097/CEJ.0b013e3282f0bff5
  13. Fousteri M, Mullenders LH (2008). Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects. Cell Res, 18, 73-84. https://doi.org/10.1038/cr.2008.6
  14. Friedberg EC (2001). How nucleotide excision repair protects against cancer. Nat Rev Cancer, 1, 22-33. https://doi.org/10.1038/35094000
  15. Gong YH, Sun LP, Jin SG, et al (2010). Comparative study of serology and histology based detection of Helicobacter pylori infections: a large population-based study of 7,241 subjects from China. Eur J Clin Microbiol Infect Dis, 29, 907-11. https://doi.org/10.1007/s10096-010-0944-9
  16. Hooker S, Bonilla C, Akereyeni F, et al (2008). NAT2 and NER genetic variants and sporadic prostate cancer susceptibility in African Americans. Prostate Cancer Prostatic Dis, 11, 349-56. https://doi.org/10.1038/sj.pcan.4501027
  17. Huang WY, Berndt SI, Kang D, et al (2006). Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. Cancer Epidemiol Biomarkers Prev, 15, 306-11. https://doi.org/10.1158/1055-9965.EPI-05-0751
  18. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  19. Lagerwerf S, Vrouwe MG, Overmeer RM, et al (2011). DNA damage response and transcription. DNA Repair (Amst), 10, 743-50. https://doi.org/10.1016/j.dnarep.2011.04.024
  20. Laine JP, Egly JM (2006). When transcription and repair meet: a complex system. Trends Genet, 22, 430-6. https://doi.org/10.1016/j.tig.2006.06.006
  21. Lauren P (1965). The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. an attempt at a histo-clinical classification. Acta Pathol Microbiol Scand, 64, 31-49.
  22. Licht CL, Stevnsner T, Bohr VA (2003). Cockayne syndrome group B cellular and biochemical functions. Am J Hum Genet, 73, 1217-39. https://doi.org/10.1086/380399
  23. Lin Z, Zhang X, Tuo J, et al (2008). A variant of the cockayne syndrome B gene ERCC6 confers risk of lung cancer. Hum Mutat, 29, 113-22. https://doi.org/10.1002/humu.20610
  24. Lochhead P, El-Omar EM (2008). Gastric cancer. Br Med Bull, 85, 87-100. https://doi.org/10.1093/bmb/ldn007
  25. Ma H, Hu Z, Wang H, et al (2009). ERCC6/CSB gene polymorphisms and lung cancer risk. Cancer Lett, 273, 172-6. https://doi.org/10.1016/j.canlet.2008.08.002
  26. Mechanic LE, Millikan RC, Player J, et al (2006). Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based casecontrol study. Carcinogenesis, 27, 1377-85. https://doi.org/10.1093/carcin/bgi330
  27. Rajaraman P, Bhatti P, Doody MM, et al (2008). Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists. Int J Cancer, 123, 2713-6. https://doi.org/10.1002/ijc.23779
  28. Rechkunova NI, Lavrik OI (2010). Nucleotide excision repair in higher eukaryotes: mechanism of primary damage recognition in global genome repair. Subcell Biochem, 50, 251-77. https://doi.org/10.1007/978-90-481-3471-7_13
  29. Sankari SL, Masthan KM, Babu NA, et al (2012). Apoptosis in cancer-an update. Asian Pac J Cancer Prev, 13, 4873-8. https://doi.org/10.7314/APJCP.2012.13.10.4873
  30. Stevnsner T, Muftuoglu M, Aamann MD, et al (2008). The role of cockayne syndrome group B (CSB) protein in base excision repair and aging. Mech Ageing Dev, 129, 441-8. https://doi.org/10.1016/j.mad.2008.04.009
  31. Sugasawa K (2011). Multiple DNA damage recognition factors involved in mammalian nucleotide excision repair. Biochemistry (Mosc), 76, 16-23. https://doi.org/10.1134/S0006297911010044
  32. Troelstra C, van Gool A, de Wit J, et al (1992). ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes. Cell, 71, 939-53. https://doi.org/10.1016/0092-8674(92)90390-X
  33. Trzyna E, Duleba M, Faryna M, et al (2012). Regulation of transcription in cancer. Front Biosci, 17, 316-30. https://doi.org/10.2741/3929
  34. Tuo J, Ning B, Bojanowski CM, et al (2006). Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition. Proc Natl Acad Sci USA, 103, 9256-61. https://doi.org/10.1073/pnas.0603485103
  35. van der Horst GT, van Steeg H, Berg RJ, et al (1997). Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition. Cell, 89, 425-35. https://doi.org/10.1016/S0092-8674(00)80223-8
  36. van Hoffen A, Balajee AS, van Zeeland AA, et al (2003). Nucleotide excision repair and its interplay with transcription. Toxicology, 193, 79-90. https://doi.org/10.1016/j.tox.2003.06.001
  37. Vauhkonen M, Vauhkonen H, Sipponen P (2006). Pathology and molecular biology of gastric cancer. Best Pract Res Clin Gastroenterol, 20, 651-74. https://doi.org/10.1016/j.bpg.2006.03.016
  38. Yuan HY, Chiou JJ, Tseng WH, et al (2006). FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res, 34, 635-41. https://doi.org/10.1093/nar/gkj469
  39. Zabaleta J (2012). Multifactorial etiology of gastric cancer. Methods Mol Biol, 863, 411-35. https://doi.org/10.1007/978-1-61779-612-8_26

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